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Institution

University of Virginia

EducationCharlottesville, Virginia, United States
About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.


Papers
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Journal ArticleDOI
TL;DR: In this article, a Leontief-based infrastructure input-output model is developed to enable an accounting of the intraconnectedness within each critical infrastructure as well as the interconnectedness among them.
Abstract: Wassily Leontief received the 1973 Nobel Price in Economics for developing what came to be known as the Leontief input-output model of the economy. Leontief's model enables understanding the interconnectedness among the various sectors of an economy and forecasting the effect on one segment of a change in another. A Leontief-based infrastructure input-output model is developed here to enable an accounting of the intraconnectedness within each critical infrastructure as well as the interconnectedness among them. The linear input/output model is then generalized into a generic risk model with the former as the first-order approximation. A preliminary study of the dynamics of risk of inoperability is discussed, using a Leontief-based dynamic model. Several examples are presented to illustrate the theory and its applications.

570 citations

Journal ArticleDOI
TL;DR: The utility of electron transfer dissociation (ETD) mass spectrometry for sequence analysis of post-translationally modified and/or highly basic peptides is reviewed to illustrate the utility of ETD as an advantageous tool in proteomic research by readily identifying peptides resistant to analysis by CAD.

569 citations

Journal ArticleDOI
TL;DR: There is a need to provide standards for patient/participant selection criteria in research focused on CAI, with justifications using the best available evidence.
Abstract: While research on chronic ankle instability (CAI) and awareness of its impact on society and health care systems has grown substantially in the last 2 decades, the inconsistency in participant/patient selection criteria across studies presents a potential obstacle to addressing the problem properly. This major gap within the literature limits the ability to generalise this evidence to the target patient population. Therefore, there is a need to provide standards for patient/participant selection criteria in research focused on CAI with justifications using the best available evidence. The International Ankle Consortium provides this position paper to present and discuss an endorsed set of selection criteria for patients with CAI based on the best available evidence to be used in future research and study designs. These recommendations will enhance the validity of research conducted in this clinical population with the end goal of bringing the research evidence to the clinician and patient.

569 citations

Proceedings ArticleDOI
02 Nov 1994
TL;DR: A survey of design issues for developing effective free-space three-dimensional (3D) user interfaces, including the use of spatial references, relative gesture, two-handed interaction, multisensory feedback, physical constraints, and head tracking is presented.
Abstract: We present a survey of design issues for developing effective free-space three-dimensional (3D) user interfaces. Our survey is based upon previous work in 3D interaction, our experience in developing free-space interfaces, and our informal observations of test users. We illustrate our design issues using examples drawn from instances of 3D interfaces.For example, our first issue suggests that users have difficulty understanding three-dimensional space. We offer a set of strategies which may help users to better perceive a 3D virtual environment, including the use of spatial references, relative gesture, two-handed interaction, multisensory feedback, physical constraints, and head tracking. We describe interfaces which employ these strategies.Our major contribution is the synthesis of many scattered results, observations, and examples into a common framework. This framework should serve as a guide to researchers or systems builders who may not be familiar with design issues in spatial input. Where appropriate, we also try to identify areas in free-space 3D interaction which we see as likely candidates for additional research.An extended and annotated version of the references list for this paper is available on-line through mosaic at address http://uvacs.cs.virginia.edu/~kph2q/.

569 citations

Journal ArticleDOI
TL;DR: Observations suggest that paxillin serves as an adapter protein, similar to insulin receptor substrate 1, and that pp125FAK may regulate the formation of signaling complexes by directing the phosphorylation of pXillin on tyrosine.
Abstract: Paxillin, a focal-adhesion-associated protein, becomes phosphorylated in response to a number of stimuli which also induce the tyrosine phosphorylation of the focal-adhesion-associated protein tyrosine kinase pp125FAK. On the basis of their colocalization and coordinate phosphorylation, paxillin is a candidate for a substrate of pp125FAK. We describe here conditions under which the phosphorylation of paxillin on tyrosine is pp125FAK dependent, supporting the hypothesis that paxillin phosphorylation is regulated by pp125FAK. pp125FAK must localize to focal adhesions and become autophosphorylated to induce paxillin phosphorylation. Phosphorylation of paxillin on tyrosine creates binding sites for the SH2 domains of Crk, Csk, and Src. We identify two sites of phosphorylation as tyrosine residues 31 and 118, each of which conforms to the Crk SH2 domain binding motif, (P)YXXP. These observations suggest that paxillin serves as an adapter protein, similar to insulin receptor substrate 1, and that pp125FAK may regulate the formation of signaling complexes by directing the phosphorylation of paxillin on tyrosine.

569 citations


Authors

Showing all 53083 results

NameH-indexPapersCitations
Joan Massagué189408149951
Michael Rutter188676151592
Gordon B. Mills1871273186451
Ralph Weissleder1841160142508
Gonçalo R. Abecasis179595230323
Jie Zhang1784857221720
John R. Yates1771036129029
John A. Rogers1771341127390
Bradley Cox1692150156200
Mika Kivimäki1661515141468
Hongfang Liu1662356156290
Carl W. Cotman165809105323
Ralph A. DeFronzo160759132993
Elio Riboli1581136110499
Dan R. Littman157426107164
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023189
2022783
20215,565
20205,600
20195,001
20184,586