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Institution

University of Virginia

EducationCharlottesville, Virginia, United States
About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.


Papers
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Journal ArticleDOI
TL;DR: The results suggest that FTY720, after phosphorylation, acts through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking.

1,482 citations

Journal ArticleDOI
TL;DR: New guidelines for laboratory testing for patients with diabetes mellitus provide specific recommendations that are based on published data or derived from expert consensus, and several analytes have minimal clinical value at present and are not recommended.
Abstract: Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus The quality of the scientific evidence supporting the use of these assays varies substantially Approach: An expert committee drafted evidence-based recommendations for the use of laboratory analysis in patients with diabetes An external panel of experts reviewed a draft of the guidelines, which were modified in response to the reviewers’ suggestions A revised draft was posted on the Internet and was presented at the AACC Annual Meeting in July, 2000 The recommendations were modified again in response to oral and written comments The guidelines were reviewed by the Professional Practice Committee of the American Diabetes Association Content: Measurement of plasma glucose remains the sole diagnostic criterion for diabetes Monitoring of glycemic control is performed by the patients, who measure their own plasma or blood glucose with meters, and by laboratory analysis of glycated hemoglobin The potential roles of noninvasive glucose monitoring, genetic testing, autoantibodies, microalbumin, proinsulin, C-peptide, and other analytes are addressed Summary: The guidelines provide specific recommendations based on published data or derived from expert consensus Several analytes are of minimal clinical value at the present time, and measurement of them is not recommended

1,481 citations

Journal ArticleDOI
TL;DR: In this article, a set of hypotheses induced from a field investigation of four microcomputer firms, where they studied how each of the top management teams went about making major decisions, were found to be paradoxes which the successful firms resolve and the unsuccessful firms do not.
Abstract: How do executives make strategic decisions in industries where the rate of technological and competitive change is so extreme that market information is often unavailable or obsolete, where strategic windows are opening and shutting quickly, and where the cost of error is involuntary exit? How do top management teams divide the decision making responsibility? And how is risk of strategic error mitigated? What we report here is a set of hypotheses induced from a field investigation of four microcomputer firms, where we studied how each of the top management teams went about making major decisions. Our goal was to extend prior work on strategic decision making to what we term high velocity environments. Our results consist of a set of paradoxes which the successful firms resolve and the unsuccessful firms do not. We found an imperative to make major decisions carefully, but to decide quickly; to have a powerful, decisive CEO and a simultaneously powerful top management team; to seek risk and innovation, but...

1,479 citations

Journal ArticleDOI
TL;DR: Results from three methods of estimating retest effects in this project converge on a conclusion that some aspects of age-related cognitive decline begin in healthy educated adults when they are in their 20s and 30s.

1,475 citations

Journal ArticleDOI
TL;DR: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis, and the dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements.
Abstract: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements. Cadherins are regulated at the cell surface by an inside-out signalling mechanism that is analogous to the integrins in platelets and leukocytes. Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond.

1,474 citations


Authors

Showing all 53083 results

NameH-indexPapersCitations
Joan Massagué189408149951
Michael Rutter188676151592
Gordon B. Mills1871273186451
Ralph Weissleder1841160142508
Gonçalo R. Abecasis179595230323
Jie Zhang1784857221720
John R. Yates1771036129029
John A. Rogers1771341127390
Bradley Cox1692150156200
Mika Kivimäki1661515141468
Hongfang Liu1662356156290
Carl W. Cotman165809105323
Ralph A. DeFronzo160759132993
Elio Riboli1581136110499
Dan R. Littman157426107164
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023189
2022783
20215,565
20205,600
20195,001
20184,586