University of Virginia

About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.

Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: Technical aspects

Abstract: PURPOSE: To describe a technique for percutaneous vertebroplasty of osteoporotic vertebral body compression fractures and to report early results of its use. METHODS: The technique was used over a 3-year period in 29 patients with 47 painful vertebral fractures. The technique involves percutaneous puncture of the involved vertebra(e) via a transpedicular approach followed by injection of polymethylmethacrylate (PMMA) into the vertebral body. RESULTS: The procedure was technically successful in all patients, with an average injection amount of 7.1 mL PMMA per vertebral body. Two patients sustained single, nondisplaced rib fractures during the procedure; otherwise, no clinically significant complications were noted. Twenty-six patients (90%) reported significant pain relief immediately after treatment. CONCLUSION: Vertebroplasty is a valuable tool in the treatment of painful osteoporotic vertebral fractures, providing acute pain relief and early mobilization in appropriate patients.

Athena: a new code for astrophysical mhd

Abstract: A new code for astrophysical magnetohydrodynamics (MHD) is described. The code has been designed to be easily extensible for use with static and adaptive mesh refinement. It combines higher order Godunov methods with the constrained transport (CT) technique to enforce the divergence-free constraint on the magnetic field. Discretization is based on cell-centered volume averages for mass, momentum, and energy, and face-centered area averages for the magnetic field. Novel features of the algorithm include (1) a consistent framework for computing the time- and edge-averaged electric fields used by CT to evolve the magnetic field from the time- and area-averaged Godunov fluxes, (2) the extension to MHD of spatial reconstruction schemes that involve a dimensionally split time advance, and (3) the extension to MHD of two different dimensionally unsplit integration methods. Implementation of the algorithm in both C and FORTRAN95 is detailed, including strategies for parallelization using domain decomposition. Results from a test suite which includes problems in one-, two-, and three-dimensions for both hydrodynamics and MHD are given, not only to demonstrate the fidelity of the algorithms, but also to enable comparisons to other methods. The source code is freely available for download on the web.

The Implicit Association Test at Age 7: A Methodological and Conceptual Review

Abstract: A mong earthly organisms, humans have a unique propensity to introspect or look inward into the contents of their own minds, and to share those observations with others. With the ability to introspect comes the palpable feeling of " knowing, " of being objective or certain, of being mentally in control of one's thoughts, aware of the causes of one's thoughts, feelings, and actions, and of making decisions deliberately and rationally. Among the noteworthy discoveries of 20th century psychology was a challenge posed to this assumption of rationality. From the groundbreaking theorizing of Herbert Simon (1955) and the mind-boggling problems posed by Kahneman, Slovik, and Tversky (1982) to striking demonstrations of illusions of control (Wegner, 2002), the paucity of introspection (Nisbett and Wilson, 1977), and the automaticity of everyday thought (Bargh, 1997), psychologists have shown the frailties of the minds of their species. As psychologists have come to grips with the limits of the mind, there has been an increased interest in measuring aspects of thinking and feeling that may not be easily accessed or available to consciousness. Innovations in measurement have been undertaken with the purpose of bringing under scrutiny new forms of cogni-tion and emotion that were previously undiscovered and especially by asking if traditional concepts such as attitude and preference, belief and stereotype, self-concept and self-esteem can be rethought based on what the new measures reveal. These newer measures do not require introspection on the part of the subject. For many constructs this is considered a valuable, if not essential, feature of measurement; for others, avoiding introspection is greeted with suspicion and skepticism. For example, one approach to measuring math ability would be to ask " how good are you at math? " whereas an alternative approach is to infer math ability via a performance on a math skills test. The former requires introspection to assess the relevant construct, the latter does not. And yet, the latter is accepted

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

Abstract: We have explored the hypothesis that contractile agonists are important regulators of smooth muscle cell growth by examining the effects of one potent contractile agonist, angiotensin II (AII), on both cell proliferation and cellular hypertrophy. AII neither stimulated proliferation of cells made quiescent in a defined serum-free media nor augmented cell proliferation induced by serum or platelet-derived growth factor. However, AII did induce cellular hypertrophy of postconfluent quiescent cultures following 4 days of treatment, increasing smooth muscle cell protein content by 20% as compared with vehicle-treated controls. AII-induced hypertrophy was maximal at 1 microM, had an ED50 of 5 nM, and was blocked by the specific AII receptor antagonist Sar1,Ile8 AII. The cellular hypertrophy was due to an increase in protein synthesis, which was elevated within 6-9 hours following AII treatment, while no changes in protein degradation were apparent. AII was even more effective in inducing hypertrophy of subconfluent cultures, causing a 38% increase in protein content after 4 days of treatment (1 microM) and showing a maximal response at concentrations as low as 0.1 nM. Interestingly, in subconfluent cultures, AII treatment (1 microM, 4 days) was associated with a 50% increase in the fraction of cells with 4C DNA content with the virtual absence of cells in S-phase of the cell cycle, consistent with either arrest of cells in the G2 phase of the cell cycle or development of tetraploidy.(ABSTRACT TRUNCATED AT 250 WORDS)