University of Warsaw

About: University of Warsaw is a education organization based out in Warsaw, Poland. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20832 authors who have published 56617 publications receiving 1185084 citations. The organization is also known as: Uniwersytet Warszawski & Warsaw University.

2D and 3D cell cultures - a comparison of different types of cancer cell cultures.

Abstract: Cell culture is a widely used in vitro tool for improving our understanding of cell biology, tissue morphology, and mechanisms of diseases, drug action, protein production and the development of tissue engineering. Most research regarding cancer biology is based on experiments using two-dimensional (2D) cell cultures in vitro. However, 2D cultures have many limitations, such as the disturbance of interactions between the cellular and extracellular environments, changes in cell morphology, polarity, and method of division. These disadvantages led to the creation of models which are more closely able to mimic conditions in vivo. One such method is three-dimensional culture (3D). Optimisation of the culture conditions may allow for a better understanding of cancer biology and facilitate the study of biomarkers and targeting therapies. In this review, we compare 2D and 3D cultures in vitro as well as different versions of 3D cultures.

Metrics and laws of software evolution-the nineties view

Abstract: The process of E-type software development and evolution has proven most difficult to improve, possibly due to the fact that the process is a multi-input, multi-output system involving feedback at many levels. This observation, first recorded in the early 1970s during an extended study of OS/360 evolution, was recently captured in a FEAST (Feedback, Evolution And Software Technology) hypothesis: a hypothesis being studied in on-going two-year project, FEAST/1. Preliminary conclusions based on a study of a financial transaction system-Logica's Fastwire (FW)-are outlined and compared with those reached during the earlier OS/360 study. The new analysis supports, or better does not contradict, the laws of software evolution, suggesting that the 1970s approach to metric analysis of software evolution is still relevant today. It is hoped that FEAST/1 will provide a foundation for mastering the feedback aspects of the software evolution process, opening up new paths for process modelling and improvement.

Combined Measurement and QCD Analysis of the Inclusive e± p Scattering Cross Sections at HERA

Abstract: A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q(2), and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.

One or more bound planets per Milky Way star from microlensing observations

Abstract: Most known extrasolar planets (exoplanets) have been discovered using the radial velocity or transit methods. Both are biased towards planets that are relatively close to their parent stars, and studies find that around 17–30% of solar-like stars host a planet. Gravitational microlensing on the other hand, probes planets that are further away from their stars. Recently, a population of planets that are unbound or very far from their stars was discovered by microlensing. These planets are at least as numerous as the stars in the Milky Way. Here we report a statistical analysis of microlensing data (gathered in 2002–07) that reveals the fraction of bound planets 0.5–10 au (Sun–Earth distance) from their stars. We find that 17^(+16)_(-9)% of stars host Jupiter-mass planets (0.3–10 M_J, where M_J = 318 M_⊕ plus and M_⊕ plus is Earth’s mass). Cool Neptunes (10–30 M_⊕ plus) and super-Earths (5–10 M_⊕ plus) are even more common: their respective abundances per star are 52^(+22)_(-29)% and 62^(+35)_(-73)% . We conclude that stars are orbited by planets as a rule, rather than the exception.

Observation and studies of jet quenching in PbPb collisions at √sNN=2.76 TeV

Abstract: Jet production in PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV was studied with the CMS detector at the LHC, using a data sample corresponding to an integrated luminosity of 6.7 inverse microbarns. Jets are reconstructed using the energy deposited in the CMS calorimeters and studied as a function of collision centrality. With increasing collision centrality, a striking imbalance in dijet transverse momentum is observed, consistent with jet quenching. The observed effect extends from the lower cut-off used in this study (jet transverse momentum = 120 GeV/c) up to the statistical limit of the available data sample (jet transverse momentum approximately 210 GeV/c). Correlations of charged particle tracks with jets indicate that the momentum imbalance is accompanied by a softening of the fragmentation pattern of the second most energetic, away-side jet. The dijet momentum balance is recovered when integrating low transverse momentum particles distributed over a wide angular range relative to the direction of the away-side jet.