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Institution

University of Warwick

EducationCoventry, Warwickshire, United Kingdom
About: University of Warwick is a education organization based out in Coventry, Warwickshire, United Kingdom. It is known for research contribution in the topics: Population & White dwarf. The organization has 26212 authors who have published 77127 publications receiving 2666552 citations. The organization is also known as: Warwick University & The University of Warwick.


Papers
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Journal ArticleDOI
TL;DR: Being bullied by peers in childhood had generally worse long-term adverse effects on young adults' mental health, and these effects were not explained by poly-victimisation.

417 citations

Journal ArticleDOI
TL;DR: It is found that concentrations of plasma methylglyoxal above 600 nM discriminate between diabetes-affected individuals with pain and those without pain, which provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy.
Abstract: Glucose and its metabolic derivatives are increased the plasma of patients with diabetes. Peter Nawroth and colleagues demonstrate that one such metabolite, methylglyoxal, is increased in patients with painful diabetic neuropathy, and find that it acts by modifying the excitability characteristics of a sodium channel protein.

417 citations

Posted Content
TL;DR: This paper derived a micro-founded measure of bilateral trade costs that indirectly infers trade frictions from observable trade data and showed that this trade cost measure is consistent with a broad range of leading trade theories including Ricardian and heterogeneous firms models.
Abstract: Barriers to international trade are known to be large but due to data limitations it is hard to measure them directly for a large number of countries over many years. To address this problem I derive a micro-founded measure of bilateral trade costs that indirectly infers trade frictions from observable trade data. I show that this trade cost measure is consistent with a broad range of leading trade theories including Ricardian and heterogeneous firms models. In an application I show that U.S. trade costs with major trading partners declined on average by about 40 percent between 1970 and 2000, with Mexico and Canada experiencing the biggest reductions.

416 citations

Journal ArticleDOI
01 Aug 2012-Sleep
TL;DR: This study corroborates the multifaceted nature of sleep problems, which is strongly linked to poorer general well-being and quality of life, and psychiatric comorbidities.
Abstract: OBJECTIVE:To estimate the prevalence of sleep problems and the effect of potential correlates in low-income settings from Africa and Asia, where the evidence is lacking. DESIGN: Cross-sectional. SETTING: Community-wide samples from 8 countries across Africa and Asia participating in the INDEPTH WHO-SAGE multicenter collaboration during 2006-2007. The participating sites included rural populations in Ghana, Tanzania, South Africa, India, Bangladesh, Vietnam, and Indonesia, and an urban area in Kenya. PARTICIPANTS: There were 24,434 women and 19,501 men age 50 yr and older. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Two measures of sleep quality, over the past 30 days, were assessed alongside a number of sociodemographic variables, measures of quality of life, and comorbidities. Overall, 16.6% of participants reported severe/extreme nocturnal sleep problems, with a striking variation across the 8 populations, ranging from 3.9% (Purworejo, Indonesia and Nairobi, Kenya) to more than 40.0% (Matlab, Bangladesh). There was a consistent pattern of higher prevalence of sleep problems in women and older age groups. In bivariate analyses, lower education, not living in partnership, and poorer self-rated quality of life were consistently associated with higher prevalence of sleep problems (P < 0.001). In multivariate logistic regression analyses, limited physical functionality or greater disability and feelings of depression and anxiety were consistently strong, independent correlates of sleep problems, in both women and men, across the 8 sites (P < 0.001). CONCLUSIONS: A large number of older adults in low-income settings are currently experiencing sleep problems, which emphasizes the global dimension of this emerging public health issue. This study corroborates the multifaceted nature of sleep problems, which are strongly linked to poorer general well-being and quality of life, and psychiatric comorbidities

416 citations

Journal ArticleDOI
TL;DR: Analysis of the model predicted the properties of these components, including an acute light induction at dawn that is rapidly repressed by LHY and CCA1, and found this unexpected regulation in RNA levels of the evening‐expressed gene GIGANTEA (GI), supporting the proposed network and making GI a strong candidate for this component.
Abstract: Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex clock network. The first part of the network to be identified, a transcriptional feedback loop comprising TIMING OF CAB EXPRESSION 1 (TOC1), LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), fails to account for significant experimental data. We develop an extended model that is based upon a wider range of data and accurately predicts additional experimental results. The model comprises interlocking feedback loops comparable to those identified experimentally in other circadian systems. We propose that each loop receives input signals from light, and that each loop includes a hypothetical component that had not been explicitly identified. Analysis of the model predicted the properties of these components, including an acute light induction at dawn that is rapidly repressed by LHY and CCA1. We found this unexpected regulation in RNA levels of the evening-expressed gene GIGANTEA (GI), supporting our proposed network and making GI a strong candidate for this component.

416 citations


Authors

Showing all 26659 results

NameH-indexPapersCitations
David Miller2032573204840
Daniel R. Weinberger177879128450
Kay-Tee Khaw1741389138782
Joseph E. Stiglitz1641142152469
Edmund T. Rolls15361277928
Thomas J. Smith1401775113919
Tim Jones135131491422
Ian Ford13467885769
Paul Harrison133140080539
Sinead Farrington133142291099
Peter Hall132164085019
Paul Brennan132122172748
G. T. Jones13186475491
Peter Simmonds13182362953
Tim Martin12987882390
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023195
2022734
20214,816
20204,927
20194,602
20184,132