Institution
University of Warwick
Education•Coventry, Warwickshire, United Kingdom•
About: University of Warwick is a education organization based out in Coventry, Warwickshire, United Kingdom. It is known for research contribution in the topics: Population & White dwarf. The organization has 26212 authors who have published 77127 publications receiving 2666552 citations. The organization is also known as: Warwick University & The University of Warwick.
Topics: Population, White dwarf, Politics, Health care, Poison control
Papers published on a yearly basis
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TL;DR: A series of alpha-functional maleimide polymethacrylates prepared via copper-catalyzed living radical polymerization (LRP) have been successfully developed and the polymers obtained in multigram scale, with an 80-100% content of maleimides reactive chain ends, depending on the method employed.
Abstract: A series of alpha-functional maleimide polymethacrylates (M(n) = 4.1-35.4 kDa, PDi = 1.06-1.27) have been prepared via copper-catalyzed living radical polymerization (LRP). Two independent synthetic protocols have been successfully developed and the polymers obtained in multigram scale, with an 80-100% content of maleimide reactive chain ends, depending on the method employed. A method for the synthesis of amino-terminated polymers, starting from Boc-protected amino initiators, has also been developed, as these derivatives are key intermediates in one of the two processes studied in the present work. The alternative synthetic pathway involves an initiator containing a maleimide unit "protected" as a Diels-Alder adduct. After the polymerization step, the maleimide functionality has been reintroduced by retro-Diels-Alder reaction, by simply refluxing those polymers in toluene for 7 h. These maleimido-terminated materials, poly(methoxyPEG((475))) methacrylates and poly(glycerol) methacrylates, differ for both the nature and size of the polymer side branches and showed an excellent solubility in water, a property that made them an ideal candidate for the synthesis of new polymer-(poly)peptide biomaterials. These functional polymers have been successfully employed in conjugation reactions in the presence of thiol-containing model substrates, namely, reduced glutathione (gamma-Glu-Cys-Gly) and the carrier protein, bovine serum albumin (BSA), in 100 mM phosphate buffer (pH 6.8-7.4) and ambient temperature.
395 citations
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01 Jan 2012TL;DR: The Nicomachean Ethics as discussed by the authors is the most complete and considered view of ethics and important themes such as friendship, happiness, the good life and virtue; as well as the grounds for compassion and mercy.
Abstract: This chapter introduces Aristotle’s work on ethics, focusing on the Nicomachean Ethics, though it makes some reference to the Eudemian Ethics and to Magna Moralia — a work traditionally attributed to Aristotle but whose authorship is questioned (Brewer, 2005). My intention is not to draw on the latter two texts to surface differences in nuance or even inconsistencies across these three texts, which might be a fruitful activity for other purposes. Instead, it is to make reference to instances where there may be something additional that can help to consolidate or emphasize important points in the Nicomachean Ethics. This reflects the established view that it is in the Nicomachean Ethics that we find Aristotle’s most complete and considered view of ethics and important themes such as friendship, happiness, the good life and virtue; as well as the grounds for compassion and mercy (Gallagher, 2009; Nussbaum, 2001b). The chapter begins by situating the Nicomachean Ethics in relation to other ideas within Aristotle’s work, before summarizing and then reviewing some of the main arguments in the text, focusing in particular on his account of intellectual virtues and the notion of phronēsis (Reeve, 2006). It concludes with a consideration of the continuing relevance of the Nicomachean Ethics from a contemporary perspective on organizations, society and politics.
395 citations
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University College London1, Alzheimer's Society2, University of Cambridge3, University of Sheffield4, Brighton and Sussex Medical School5, Bangor University6, Ludwig Maximilian University of Munich7, Imperial College London8, Technische Universität München9, Oxford Health NHS Foundation Trust10, University of Hertfordshire11, University of Manchester12, Cardiff University13, University of East Anglia14, University of Bath15, University of Warwick16, University of Hull17, University of Nottingham18, University of Oxford19, Leeds Beckett University20, University of Exeter21, Wolfson Centre for Age-Related Diseases22, St George's, University of London23, University of Bristol24, Queen's University Belfast25, University of Southampton26, Aston University27, Newcastle University28, Camden and Islington NHS Foundation Trust29
TL;DR: This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia, and recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs.
Abstract: Background There are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia. Methods and findings We defined disease-modification interventions as those aiming to change the underlying pathology. We systematically searched electronic databases and previous systematic reviews for published and ongoing trials of disease-modifying treatments in mild-to-moderate dementia. We included 149/22,918 of the references found; with 81 outcome measures from 125 trials. Trials involved participants with Alzheimer’s disease (AD) alone (n = 111), or AD and mild cognitive impairment (n = 8) and three vascular dementia. We divided outcomes by the domain measured (cognition, activities of daily living, biological markers, neuropsychiatric symptoms, quality of life, global). We calculated the number of trials and of participants using each outcome. We detailed psychometric properties of each outcome. We sought the views of people living with dementia and family carers in three cities through Alzheimer’s society focus groups. Attendees at a consensus conference (experts in dementia research, disease-modification and harmonisation measures) decided on the core set of outcomes using these results. Recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs. Cognition should be measured by Mini Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale. MRIs would be optional for patients. We also made recommendations for measuring important, but non-core domains which may not change despite disease modification. Limitations Most trials were about AD. Specific instruments may be superseded. We searched one database for psychometric properties. Interpretation This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia. Our recommendations will facilitate designing, comparing and meta-analysing disease modification trials in mild-to-moderate dementia, increasing their value.
394 citations
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TL;DR: Based on the growing information on Luxl and LuxR homologues in other N‐AHL‐producing bacterial species, it seems that analogues of the P. fischeri lux autoinducer sensing system are widely distributed in bacteria.
Abstract: In recent years it has become clear that the production of N-acyl homoserine lactones (N-AHLs) is widespread in Gram-negative bacteria. These molecules act as diffusible chemical communication signals (bacterial pheromones) which regulate diverse physiological processes including bioluminescence, antibiotic production, plasmid conjugal transfer and synthesis of exoenzyme virulence factors in plant and animal pathogens. The paradigm for N-AHL production is in the bioluminescence (lux) phenotype of Photobacterium fischeri (formerly classified as Vibrio fischeri) where the signalling molecule N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) is synthesized by the action of the LuxI protein. OHHL is thought to bind to the LuxR protein, allowing it to act as a positive transcriptional activator in an autoinduction process that physiologically couples cell density (and growth phase) to the expression of the bioluminescence genes. Based on the growing information on LuxI and LuxR homologues in other N-AHL-producing bacterial species such as Erwinia carotovora, Pseudomonas aeruginosa, Yersinia enterocolitica, Agrobacterium tumefaciens and Rhizobium leguminosarum, it seems that analogues of the P. fischeri lux autoinducer sensing system are widely distributed in bacteria. The general physiological function of these simple chemical signalling systems appears to be the modulation of discrete and diverse metabolic processes in concert with cell density. In an evolutionary sense, the elaboration and action of these bacterial pheromones can be viewed as an example of multicellularity in prokaryotic populations.
394 citations
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TL;DR: This chapter discusses the metabolic aspects of aerobic obligate methanotrophy, a unique group of gram-negative bacteria that use methane as carbon and energy source and a vital role in the global methane cycle.
Abstract: Publisher Summary This chapter discusses the metabolic aspects of aerobic obligate methanotrophy. Aerobic methanotrophs are a unique group of gram-negative bacteria that use methane as carbon and energy source. Methanotrophs have been studied intensively over the past 40 years since these bacteria possess significant metabolic potential for practical use in the biotransformation of a variety of organic substrates, bioremediation of pollutants the production of single-cell protein (SCP), and value-added products. They also play a vital role in the global methane cycle, mitigating the emissions and green-house effects of methane on the Earth's climate. Methanotrophs build all of their cell constituents from C1 compounds by employing special biosynthetic pathways for phosphotrioses, which are different from those of heterotrophic bacteria.
394 citations
Authors
Showing all 26659 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Miller | 203 | 2573 | 204840 |
Daniel R. Weinberger | 177 | 879 | 128450 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Joseph E. Stiglitz | 164 | 1142 | 152469 |
Edmund T. Rolls | 153 | 612 | 77928 |
Thomas J. Smith | 140 | 1775 | 113919 |
Tim Jones | 135 | 1314 | 91422 |
Ian Ford | 134 | 678 | 85769 |
Paul Harrison | 133 | 1400 | 80539 |
Sinead Farrington | 133 | 1422 | 91099 |
Peter Hall | 132 | 1640 | 85019 |
Paul Brennan | 132 | 1221 | 72748 |
G. T. Jones | 131 | 864 | 75491 |
Peter Simmonds | 131 | 823 | 62953 |
Tim Martin | 129 | 878 | 82390 |