Institution
University of Waterloo
Education•Waterloo, Ontario, Canada•
About: University of Waterloo is a education organization based out in Waterloo, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 36093 authors who have published 93906 publications receiving 2948139 citations. The organization is also known as: UW & uwaterloo.
Papers published on a yearly basis
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Daniel J. Klionsky1, Amal Kamal Abdel-Aziz2, Sara Abdelfatah3, Mahmoud Abdellatif4 +2980 more•Institutions (777)
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
1,129 citations
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TL;DR: It is shown that by judicious design of nanofins on a surface, it is possible to simultaneously control the phase, group delay and group delay dispersion of light, thereby achieving a transmissive achromatic metalens with large bandwidth.
Abstract: A key goal of metalens research is to achieve wavefront shaping of light using optical elements with thicknesses on the order of the wavelength. Such miniaturization is expected to lead to compact, nanoscale optical devices with applications in cameras, lighting, displays and wearable optics. However, retaining functionality while reducing device size has proven particularly challenging. For example, so far there has been no demonstration of broadband achromatic metalenses covering the entire visible spectrum. Here, we show that by judicious design of nanofins on a surface, it is possible to simultaneously control the phase, group delay and group delay dispersion of light, thereby achieving a transmissive achromatic metalens with large bandwidth. We demonstrate diffraction-limited achromatic focusing and achromatic imaging from 470 to 670 nm. Our metalens comprises only a single layer of nanostructures whose thickness is on the order of the wavelength, and does not involve spatial multiplexing or cascading. While this initial design (numerical aperture of 0.2) has an efficiency of about 20% at 500 nm, we discuss ways in which our approach may be further optimized to meet the demand of future applications. Controlling the geometry of each dielectric element of a nanostructured surface enables frequency-dependent group delay and group delay dispersion engineering, and the fabrication of an achromatic metalens for imaging in the visible in transmission.
1,126 citations
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01 Sep 19961,124 citations
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TL;DR: In this paper, the cosmological constant was treated as a thermodynamic pressure and its conjugate quantity as a temperature volume, and the critical point of divergence of specific heat at constant pressure was studied.
Abstract: Treating the cosmological constant as a thermodynamic pressure and its conjugate quantity as a thermodynamic volume, we reconsider the critical behaviour of charged AdS black holes. We complete the analogy of this system with the liquid-gas system and study its critical point, which occurs at the point of divergence of specific heat at constant pressure. We calculate the critical exponents and show that they coincide with those of the Van der Waals system.
1,124 citations
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TL;DR: In the presence of salt the bacterium increased the water use efficiency (WUE), which may suggest that the bacteriod act to alleviate the salt suppression of photosynthesis, however, the detailed mechanism was not elucidated.
1,119 citations
Authors
Showing all 36498 results
Name | H-index | Papers | Citations |
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John J.V. McMurray | 178 | 1389 | 184502 |
David A. Weitz | 178 | 1038 | 114182 |
David Taylor | 131 | 2469 | 93220 |
Lei Zhang | 130 | 2312 | 86950 |
Will J. Percival | 129 | 473 | 87752 |
Trevor Hastie | 124 | 412 | 202592 |
Stephen Mann | 120 | 669 | 55008 |
Xuan Zhang | 119 | 1530 | 65398 |
Mark A. Tarnopolsky | 115 | 644 | 42501 |
Qiang Yang | 112 | 1117 | 71540 |
Wei Zhang | 112 | 1189 | 93641 |
Hans-Peter Seidel | 112 | 1213 | 51080 |
Theodore S. Rappaport | 112 | 490 | 68853 |
Robert C. Haddon | 112 | 577 | 52712 |
David Zhang | 111 | 1027 | 55118 |