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Institution

University of Waterloo

EducationWaterloo, Ontario, Canada
About: University of Waterloo is a education organization based out in Waterloo, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 36093 authors who have published 93906 publications receiving 2948139 citations. The organization is also known as: UW & uwaterloo.


Papers
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Journal ArticleDOI
TL;DR: Brown et al. as mentioned in this paper investigated the sensitivity of mean variance-efficient portfolios to changes in the means of individual assets and found that a positively weigbted mean-variance-efficient portfolio's weights, mean, and variance can be extremely sensitive to cbanges in asset means.
Abstract: Tbis paper investigates the sensitivity of meanvariance(MV)-efficientportfolios to changes in the means of individual assets. When only a budget constraint is imposed on the investment problem, the analytical results indicate that an MV-efficient portfolio's weights, mean, and variance can be extremely sensitive to cbanges in asset means. When nonnegativity constraints are also imposed on the problem, the computational results confirm that a positively weigbted MV-efficient portfolio's weigbts are extremely sensitive to cbanges in asset means, but the portfolio's returns are not. A surprisingly small increase in the mean of Just one asset drives balf the securities from the portfolio. Yet the portfolio's expected return and standard deviation are virtually uncbanged. This paper supersedes "Should Investors Hold Well-Diversified Portfolios?" Financial support from the Natural Science and Engineering Research Council of Canada is gratefully acknowledged. We also acknowledge the most capable assistance of Ruth Cornale, Simon Ng, Jean-Marc Potier, and Frederick Shen. The paper was presented at Simon Fraser University and the Western Finance Association meetings in San Diego. We thank the participants, especially Stephen Brown, John Herzog, John Heaney, Ray Koopman, and Bruce Lehmann, and the editors, Jon Ingersoll and Chester Spatt, for

947 citations

Journal ArticleDOI
01 Nov 2012
TL;DR: A comprehensive survey to examine the development and current status of various aspects of sensor-based activity recognition, making a primary distinction in this paper between data-driven and knowledge-driven approaches.
Abstract: Research on sensor-based activity recognition has, recently, made significant progress and is attracting growing attention in a number of disciplines and application domains. However, there is a lack of high-level overview on this topic that can inform related communities of the research state of the art. In this paper, we present a comprehensive survey to examine the development and current status of various aspects of sensor-based activity recognition. We first discuss the general rationale and distinctions of vision-based and sensor-based activity recognition. Then, we review the major approaches and methods associated with sensor-based activity monitoring, modeling, and recognition from which strengths and weaknesses of those approaches are highlighted. We make a primary distinction in this paper between data-driven and knowledge-driven approaches, and use this distinction to structure our survey. We also discuss some promising directions for future research.

944 citations

Journal ArticleDOI
TL;DR: P porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles are reported that allow a single protocell loaded with a drug cocktail to kill a drug-resistant HCC cell, representing a 106-fold improvement over comparable liposome.
Abstract: Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine. To realize this potential, however, targeted nanocarriers must simultaneously overcome multiple challenges, including specificity, stability and a high capacity for disparate cargos. Here we report porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles. Protocells modified with a targeting peptide that binds to human hepatocellular carcinoma exhibit a 10,000-fold greater affinity for human hepatocellular carcinoma than for hepatocytes, endothelial cells or immune cells. Furthermore, protocells can be loaded with combinations of therapeutic (drugs, small interfering RNA and toxins) and diagnostic (quantum dots) agents and modified to promote endosomal escape and nuclear accumulation of selected cargos. The enormous capacity of the high-surface-area nanoporous core combined with the enhanced targeting efficacy enabled by the fluid supported lipid bilayer enable a single protocell loaded with a drug cocktail to kill a drug-resistant human hepatocellular carcinoma cell, representing a 10(6)-fold improvement over comparable liposomes.

944 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present six areas of tourism in which VR may prove particularly valuable: planning and management, marketing, entertainment, education, accessibility, and heritage preservation, and numerous suggestions for future research are presented.

937 citations

Journal ArticleDOI
Ning Lu1, Nan Cheng1, Ning Zhang1, Xuemin Shen1, Jon W. Mark1 
TL;DR: The challenges and potential challenges to provide vehicle-to-x connectivity are discussed and the state-of-the-art wireless solutions for vehicle-To-sensor, vehicle- to-vehicle, motorway infrastructure connectivities are reviewed.
Abstract: Providing various wireless connectivities for vehicles enables the communication between vehicles and their internal and external environments. Such a connected vehicle solution is expected to be the next frontier for automotive revolution and the key to the evolution to next generation intelligent transportation systems (ITSs). Moreover, connected vehicles are also the building blocks of emerging Internet of Vehicles (IoV). Extensive research activities and numerous industrial initiatives have paved the way for the coming era of connected vehicles. In this paper, we focus on wireless technologies and potential challenges to provide vehicle-to-x connectivity. In particular, we discuss the challenges and review the state-of-the-art wireless solutions for vehicle-to-sensor, vehicle-to-vehicle, vehicle-to-Internet, and vehicle-to-road infrastructure connectivities. We also identify future research issues for building connected vehicles.

936 citations


Authors

Showing all 36498 results

NameH-indexPapersCitations
John J.V. McMurray1781389184502
David A. Weitz1781038114182
David Taylor131246993220
Lei Zhang130231286950
Will J. Percival12947387752
Trevor Hastie124412202592
Stephen Mann12066955008
Xuan Zhang119153065398
Mark A. Tarnopolsky11564442501
Qiang Yang112111771540
Wei Zhang112118993641
Hans-Peter Seidel112121351080
Theodore S. Rappaport11249068853
Robert C. Haddon11257752712
David Zhang111102755118
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023213
2022701
20215,359
20205,388
20195,200