Showing papers by "University of Western Australia published in 2011"
Stephen Sawcer1, Garrett Hellenthal2, Matti Pirinen2, Chris C. A. Spencer2 +262 more•Institutions (67)
TL;DR: In this article, a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, they have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci.
Abstract: Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
2,511 citations
TL;DR: In this article, a large-scale correlation function of the 6dF Galaxy Survey (6dFGS) and detect a baryon acoustic oscillation (BAO) signal at 105h −1 Mpc was analyzed.
Abstract: We analyse the large-scale correlation function of the 6dF Galaxy Survey (6dFGS) and detect a baryon acoustic oscillation (BAO) signal at 105h −1 Mpc. The 6dFGS BAO detection allows us to constrain the distance–redshift relation at zeff = 0.106. We achieve a distance measure of DV (zeff) = 457 ± 27 Mpc and a measurement of the distance ratio, rs(zd)/DV (zeff) = 0.336 ± 0.015 (4.5 per cent precision), where rs(zd) is the sound horizon at the drag epoch zd .T he loweffective redshift of 6dFGS makes it a competitive and independent alternative to Cepheids and low-z supernovae in constraining the Hubble constant. We find a Hubble constant of H0 = 67 ± 3.2 km s −1 Mpc −1 (4.8 per cent precision) that depends only on theWilkinson Microwave Anisotropy Probe-7 (WMAP-7) calibration of the sound horizon and on the galaxy clustering in 6dFGS. Compared to earlier BAO studies at higher redshift, our analysis is less dependent on other cosmological parameters. The sensitivity to H0 can be used to break the degeneracy between the dark energy equation of state parameter w and H0 in the cosmic microwave background data. We determine that w =− 0.97 ± 0.13, using only WMAP-7 and BAO data from both 6dFGS and Percival et al. (2010). We also discuss predictions for the large-scale correlation function of two future wide-angle surveys: the Wide field ASKAP L-band Legacy All-sky Blind surveY (WALLABY) blind H I survey (with the Australian Square Kilometre Array Pathfinder, ASKAP) and the proposed Transforming Astronomical Imaging surveys through Polychromatic Analysis of Nebulae (TAIPAN) all-southern-sky optical galaxy survey with the UK Schmidt Telescope. We find that both surveys are very likely to yield detections of the BAO peak, making WALLABY the first radio galaxy survey to do so. We also predict that TAIPAN has the potential to constrain the Hubble constant with 3 per cent precision.
2,435 citations
TL;DR: In this paper, the authors identify key areas of uncertainty and specific actions needed to address them and identify the value of mangrove forests, seagrass beds, and salt marshes in sequestering carbon dioxide.
Abstract: Recent research has highlighted the valuable role that coastal and marine ecosystems play in sequestering carbon dioxide (CO(2)). The carbon (C) sequestered in vegetated coastal ecosystems, specifically mangrove forests, seagrass beds, and salt marshes, has been termed blue carbon. Although their global area is one to two orders of magnitude smaller than that of terrestrial forests, the contribution of vegetated coastal habitats per unit area to long-term C sequestration is much greater, in part because of their efficiency in trapping suspended matter and associated organic C during tidal inundation. Despite the value of mangrove forests, seagrass beds, and salt marshes in sequestering C, and the other goods and services they provide, these systems are being lost at critical rates and action is urgently needed to prevent further degradation and loss. Recognition of the C sequestration value of vegetated coastal ecosystems provides a strong argument for their protection and restoration; however, it is necessary to improve scientific understanding of the underlying mechanisms that control C sequestration in these ecosystems. Here, we identify key areas of uncertainty and specific actions needed to address them.
2,313 citations
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Abstract: Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
1,829 citations
Stephan Ripke1, Alan R. Sanders2, Kenneth S. Kendler3, Douglas F. Levinson4 +207 more•Institutions (71)
TL;DR: The authors examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects.
Abstract: We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 x 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 x 10(-9)), ANK3 (rs10994359, P = 2.5 x 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 x 10(-9)).
1,671 citations
TL;DR: Overall, current data provide strong concordant evidence that n-3 PUFA are bioactive compounds that reduce risk of cardiac death.
1,501 citations
TL;DR: It is found that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells.
Abstract: Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo.
1,478 citations
Wellcome Trust Sanger Institute1, Université de Montréal2, University of Edinburgh3, University of Kiel4, Karolinska Institutet5, Cedars-Sinai Medical Center6, University of Cambridge7, University of Pennsylvania8, Casa Sollievo della Sofferenza9, University of Pittsburgh10, Université libre de Bruxelles11, University of Otago12, Johns Hopkins University13, Ludwig Maximilian University of Munich14, Charité15, Lille University of Science and Technology16, Cincinnati Children's Hospital Medical Center17, Ghent University18, Torbay Hospital19, University of Groningen20, Mater Health Services21, University of Liège22, University of Washington23, University of Utah24, QIMR Berghofer Medical Research Institute25, University of Paris26, University of Western Australia27, Tel Aviv University28, University of Dundee29, Harvard University30, University of Manchester31, Utrecht University32, University of Florence33, King's College London34, Yale University35, Royal Hospital for Sick Children36, Katholieke Universiteit Leuven37, Guy's and St Thomas' NHS Foundation Trust38, University of Barcelona39, University of Chicago40, University of Bern41, University of California, San Francisco42, Agency for Science, Technology and Research43, University of Toronto44, University of Oslo45, Leiden University46, University of Amsterdam47, Aarhus University48, National and Kapodistrian University of Athens49, Lithuanian University of Health Sciences50, Newcastle University51, Emory University52, Örebro University53, French Institute of Health and Medical Research54, Center for Applied Genomics55
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Abstract: Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
1,291 citations
13 Jul 2011
1,119 citations
Scottish Association for Marine Science1, Nelson Mandela Metropolitan University2, Ulster University3, University of North Carolina at Chapel Hill4, Edith Cowan University5, Aberystwyth University6, Commonwealth Scientific and Industrial Research Organisation7, Technical University of Denmark8, University of Queensland9, Spanish National Research Council10, University of Western Australia11, University of California, Santa Barbara12, Museum für Naturkunde13, University of British Columbia14, University of Texas at Austin15, National Oceanic and Atmospheric Administration16
TL;DR: Two measures of thermal shifts from analyses of global temperatures over the past 50 years are used to describe the pace of climate change that species should track: the velocity ofClimate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures.
Abstract: Climate change challenges organisms to adapt or move to track changes in environments in space and time. We used two measures of thermal shifts from analyses of global temperatures over the past 50 years to describe the pace of climate change that species should track: the velocity of climate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures. Both measures are higher in the ocean than on land at some latitudes, despite slower ocean warming. These indices give a complex mosaic of predicted range shifts and phenology changes that deviate from simple poleward migration and earlier springs or later falls. They also emphasize potential conservation concerns, because areas of high marine biodiversity often have greater velocities of climate change and seasonal shifts.
1,101 citations
French Institute of Health and Medical Research1, Columbia University2, The Catholic University of America3, University of Gothenburg4, University of Milan5, New York University6, Forest Research Institute7, University of Amsterdam8, University of Copenhagen9, St George's, University of London10, Hacettepe University11, University of Western Australia12
TL;DR: Recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal, and that therapeutic targeting of elevated triglycerides, a marker of TRL and their remnants, and/or low HDL-C may provide further benefit.
Abstract: Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) to advise on therapeutic strategies for management. Current evidence supports a causal association between elevated TRL and their remnants, low HDL-C, and cardiovascular risk. This interpretation is based on mechanistic and genetic studies for TRL and remnants, together with the epidemiological data suggestive of the association for circulating triglycerides and cardiovascular disease. For HDL, epidemiological, mechanistic, and clinical intervention data are consistent with the view that low HDL-C contributes to elevated cardiovascular risk; genetic evidence is unclear however, potentially reflecting the complexity of HDL metabolism. The Panel believes that therapeutic targeting of elevated triglycerides (≥1.7 mmol/L or 150 mg/dL), a marker of TRL and their remnants, and/or low HDL-C (<1.0 mmol/L or 40 mg/dL) may provide further benefit. The first step should be lifestyle interventions together with consideration of compliance with pharmacotherapy and secondary causes of dyslipidaemia. If inadequately corrected, adding niacin or a fibrate, or intensifying LDL-C lowering therapy may be considered. Treatment decisions regarding statin combination therapy should take into account relevant safety concerns, i.e. the risk of elevation of blood glucose, uric acid or liver enzymes with niacin, and myopathy, increased serum creatinine and cholelithiasis with fibrates. These recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal.
University of St Andrews1, European Southern Observatory2, University of Edinburgh3, Liverpool John Moores University4, University of Nottingham5, Australian Astronomical Observatory6, University of Sussex7, Max Planck Society8, University of Sydney9, Monash University, Clayton campus10, École Polytechnique Fédérale de Lausanne11, Cardiff University12, University of Queensland13, Swinburne University of Technology14, University of Portsmouth15, University of Bristol16, University of Central Lancashire17, University of Melbourne18, Durham University19, University of Hertfordshire20, Carnegie Institution for Science21, University of Western Australia22, Queen Mary University of London23, Imperial College London24
TL;DR: The Galaxy and Mass Assembly (GAMA) survey has been operating since 2008 February on the 3.9m Anglo-Australian Telescope using the AAOmega fibre-fed spectrograph facility to acquire spectra with a resolution of R ≈ 1300 for 120 862 Sloan Digital Sky Survey selected galaxies.
Abstract: The Galaxy and Mass Assembly (GAMA) survey has been operating since 2008 February on the 3.9-m Anglo-Australian Telescope using the AAOmega fibre-fed spectrograph facility to acquire spectra with a resolution of R ≈ 1300 for 120 862 Sloan Digital Sky Survey selected galaxies. The target catalogue constitutes three contiguous equatorial regions centred at 9h (G09), 12h (G12) and 14.5h (G15) each of 12 × 4 deg2 to limiting fluxes of rpet < 19.4, rpet < 19.8 and rpet <19.4 mag, respectively (and additional limits at other wavelengths). Spectra and reliable redshifts have been acquired for over 98 per cent of the galaxies within these limits. Here we present the survey footprint, progression, data reduction, redshifting, re-redshifting, an assessment of data quality after 3 yr, additional image analysis products (including ugrizYJHK photometry, S´ersic profiles and photometric redshifts), observing mask and construction of our core survey catalogue (GamaCore). From this we create three science-ready catalogues: GamaCoreDR1 for public release, which includes data acquired during year 1 of operations within specified magnitude limits (2008 February to April); GamaCoreMainSurvey containing all data above our survey limits for use by the GAMA Team and collaborators; and GamaCore-AtlasSV containing year 1, 2 and 3 data matched to Herschel-ATLAS science demonstration data. These catalogues along with the associated spectra, stamps and profiles can be accessed via the GAMA website: http://www.gama-survey.org/
Swinburne University of Technology1, New York University2, University of Western Australia3, University of Queensland4, University of Copenhagen5, Australian Astronomical Observatory6, University of Sydney7, California Institute of Technology8, University of Waterloo9, University of Chicago10, Australia Telescope National Facility11, Carnegie Institution for Science12, Monash University, Clayton campus13, Australian National University14, University of British Columbia15, University of Toronto16
TL;DR: In this paper, the authors present measurements of the baryon acoustic peak at redshifts z = 0.44, 0.6 and 0.73 in the galaxy correlation function of the final dataset of the WiggleZ Dark Energy Survey.
Abstract: We present measurements of the baryon acoustic peak at redshifts z = 0.44, 0.6 and 0.73 in the galaxy correlation function of the final dataset of the WiggleZ Dark Energy Survey. We combine our correlation function with lower-redshift measurements from the 6-degree Field Galaxy Survey and Sloan Digital Sky Survey, producing a stacked survey correlation function in which the statistical significance of the detection of the baryon acoustic peak is 4.9-σ relative to a zero-baryon model with no peak. We fit cosmological models to this combined baryon acoustic oscillation (BAO) dataset comprising six distance-redshift data points, and compare the results to similar fits to the latest compilation of supernovae (SNe) and Cosmic Microwave Background (CMB) data. The BAO and SNe datasets produce consistent measurements of the equation-ofstate w of dark energy, when separately combined with the CMB, providing a powerful check for systematic errors in either of these distance probes. Combining all datasets we determine w = 1.03 ± 0.08 for a flat Universe, consistent with a cosmological constant model. Assuming dark energy is a cosmological constant and varying the spatial curvature, we find k = 0.004± 0.006.
Royal Perth Hospital1, University of Western Australia2, Northern General Hospital3, University of Liège4, French Institute of Health and Medical Research5, University of South Australia6, University of California, Los Angeles7, International Osteoporosis Foundation8, Southampton General Hospital9, University of Oxford10, University of Sheffield11
TL;DR: BTM hold promise in fracture risk prediction and for monitoring treatment and Uncertainties over their clinical use can be in part resolved by adopting international reference standards.
Abstract: The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker of bone formation (serum procollagen type I N propeptide, s-PINP) and a marker of bone resorption (serum C-terminal telopeptide of type I collagen, s-CTX) are used as reference analytes for bone turnover markers in clinical studies. Bone turnover markers (BTM) predict fracture risk, and treatment-induced changes in specific markers account for a substantial proportion of fracture risk reduction. The aims of this report were to determine their clinical potential in the prediction of fracture risk and for monitoring the treatment of osteoporosis and to set an appropriate research agenda. Evidence from prospective studies was gathered through literature review of the PUBMED database between the years 2000 and 2010 and the systematic review of the Agency for Healthcare Research and Quality up to 2001. High levels of BTMs may predict fracture risk independently from bone mineral density in postmenopausal women. They have been used for this purpose in clinical practice for many years, but there is still a need for stronger evidence on which to base practice. BTMs provide pharmacodynamic information on the response to osteoporosis treatment, and as a result, they are widely used for monitoring treatment in the individual. However, their clinical value for monitoring is limited by inadequate appreciation of the sources of variability, by limited data for comparison of treatments using the same BTM and by inadequate quality control. IOF/IFCC recommend one bone formation marker (s-PINP) and one bone resorption marker (s-CTX) to be used as reference markers and measured by standardised assays in observational and intervention studies in order to compare the performance of alternatives and to enlarge the international experience of the application of markers to clinical medicine. BTM hold promise in fracture risk prediction and for monitoring treatment. Uncertainties over their clinical use can be in part resolved by adopting international reference standards.
TL;DR: The safety and biochemical efficacy presented show the potential of AVI-4658 to become a disease-modifying drug for Duchenne muscular dystrophy.
Macalester College1, Arizona State University2, University of Western Australia3, United States Forest Service4, University of Florida5, University of California, Davis6, University of New Mexico7, University of Arizona8, Charles Darwin Foundation9, University of Sheffield10, Institute of Ecosystem Studies11, University of California, Berkeley12, Rutgers University13, Stanford University14, University of South Florida15
TL;DR: Conservationists should assess organisms on environmental impact rather than on whether they are natives, argue Mark Davis and 18 other ecologists.
Abstract: Conservationists should assess organisms on environmental impact rather than on whether they are natives, argue Mark Davis and 18 other ecologists.
TL;DR: In this paper, the authors demonstrate the squeezed-light enhancement of GEO600, which will be the GW observatory operated by the LIGO Scientific Collaboration in its search for GWs for the next 3-4 years.
Abstract: Around the globe several observatories are seeking the first direct detection of gravitational waves (GWs). These waves are predicted by Einstein’s general theory of relativity1 and are generated, for example, by black-hole binary systems2. Present GW detectors are Michelson-type kilometre-scale laser interferometers measuring the distance changes between mirrors suspended in vacuum. The sensitivity of these detectors at frequencies above several hundred hertz is limited by the vacuum (zero-point) fluctuations of the electromagnetic field. A quantum technology—the injection of squeezed light3—offers a solution to this problem. Here we demonstrate the squeezed-light enhancement of GEO 600, which will be the GW observatory operated by the LIGO Scientific Collaboration in its search for GWs for the next 3–4 years. GEO 600 now operates with its best ever sensitivity, which proves the usefulness of quantum entanglement and the qualification of squeezed light as a key technology for future GW astronomy4.
TL;DR: In this paper, the impact of temperature variability and changes in averages and extremes on wheat production has been quantified, and it was shown that increased leaf senescence can be attributed to increased temperature >34°C.
Abstract: With current annual production at over 600 million tonnes, wheat is the third largest crop in the world behind corn and rice, and an essential source of carbohydrates for millions of people. While wheat is grown over a wide range of environments, it is common in the major wheat-producing countries for grain filling to occur when soil moisture is declining and temperature is increasing. Average global temperatures have increased over the last decades and are predicted to continue rising, along with a greater frequency of extremely hot days. Such events have already been reported for major wheat growing regions in the world. However, the direct impact of past temperature variability and changes in averages and extremes on wheat production has not been quantified. Attributing changes in observed yields over recent decades to a single factor such as temperature is not possible due to the confounding effects of other factors. By using simulation modelling, we were able to separate the impact of temperature from other factors and show that the effect of temperature on wheat production has been underestimated. Surprisingly, observed variations in average growing-season temperatures of ±2 °C in the main wheat growing regions of Australia can cause reductions in grain production of up to 50%. Most of this can be attributed to increased leaf senescence as a result of temperatures >34 °C. Temperature conditions during grain filling in the major wheat growing regions of the world are similar to the Australian conditions during grain filling. With average temperatures and the frequency of heat events projected to increase world-wide with global warming, yield reductions due to higher temperatures during the important grain-filling stage alone could substantially undermine future global food security. Adaptation strategies need to be considered now to prevent substantial yield losses in wheat from increasing future heat stress.
Pennington Biomedical Research Center1, University of Sydney2, University of Queensland3, Loughborough University4, Ghent University5, University of Western Australia6, Tokyo Gakugei University7, Tokyo Medical University8, University of Strathclyde9, University of Georgia10, Menzies Research Institute11, Auckland University of Technology12, University of Alberta13, Technical University of Lisbon14, Queen's University Belfast15, University of South Carolina16
TL;DR: The purpose of this review was to update existing knowledge of "How many steps/day are enough?", and to inform step-based recommendations consistent with current physical activity guidelines.
Abstract: Physical activity guidelines from around the world are typically expressed in terms of frequency, duration, and intensity parameters. Objective monitoring using pedometers and accelerometers offers a new opportunity to measure and communicate physical activity in terms of steps/day. Various step-based versions or translations of physical activity guidelines are emerging, reflecting public interest in such guidance. However, there appears to be a wide discrepancy in the exact values that are being communicated. It makes sense that step-based recommendations should be harmonious with existing evidence-based public health guidelines that recognize that "some physical activity is better than none" while maintaining a focus on time spent in moderate-to-vigorous physical activity (MVPA). Thus, the purpose of this review was to update our existing knowledge of "How many steps/day are enough?", and to inform step-based recommendations consistent with current physical activity guidelines. Normative data indicate that healthy adults typically take between 4,000 and 18,000 steps/day, and that 10,000 steps/day is reasonable for this population, although there are notable "low active populations." Interventions demonstrate incremental increases on the order of 2,000-2,500 steps/day. The results of seven different controlled studies demonstrate that there is a strong relationship between cadence and intensity. Further, despite some inter-individual variation, 100 steps/minute represents a reasonable floor value indicative of moderate intensity walking. Multiplying this cadence by 30 minutes (i.e., typical of a daily recommendation) produces a minimum of 3,000 steps that is best used as a heuristic (i.e., guiding) value, but these steps must be taken over and above habitual activity levels to be a true expression of free-living steps/day that also includes recommendations for minimal amounts of time in MVPA. Computed steps/day translations of time in MVPA that also include estimates of habitual activity levels equate to 7,100 to 11,000 steps/day. A direct estimate of minimal amounts of MVPA accumulated in the course of objectively monitored free-living behaviour is 7,000-8,000 steps/day. A scale that spans a wide range of incremental increases in steps/day and is congruent with public health recognition that "some physical activity is better than none," yet still incorporates step-based translations of recommended amounts of time in MVPA may be useful in research and practice. The full range of users (researchers to practitioners to the general public) of objective monitoring instruments that provide step-based outputs require good reference data and evidence-based recommendations to be able to design effective health messages congruent with public health physical activity guidelines, guide behaviour change, and ultimately measure, track, and interpret steps/day.
TL;DR: The dust cycle is an integral part of the Earth system as discussed by the authors, it carries organic material, contributes directly to the carbon cycle and carries iron which is vital to ocean productivity and the ocean-atmosphere CO2 exchange.
TL;DR: Increased research in understudied ecosystems, on key issues related to seed ecology, and on evolution of seed traits in nonweedy species is needed to more fully comprehend and plan for plant responses to global warming.
Abstract: At the core of plant regeneration, temperature and water supply are critical drivers for seed dormancy (initiation, break) and germination. Hence, global climate change is altering these environmental cues and will preclude, delay, or enhance regeneration from seeds, as already documented in some cases. Along with compromised seedling emergence and vigour, shifts in germination phenology will influence population dynamics, and thus, species composition and diversity of communities. Altered seed maturation (including consequences for dispersal) and seed mass will have ramifications on life history traits of plants. Predicted changes in temperature and precipitation, and thus in soil moisture, will affect many components of seed persistence in soil, e.g. seed longevity, dormancy release and germination, and soil pathogen activity. More/less equitable climate will alter geographic distribution for species, but restricted migratory capacity in some will greatly limit their response. Seed traits for weedy species could evolve relatively quickly to keep pace with climate change enhancing their negative environmental and economic impact. Thus, increased research in understudied ecosystems, on key issues related to seed ecology, and on evolution of seed traits in nonweedy species is needed to more fully comprehend and plan for plant responses to global warming.
James Cook University1, Smithsonian Tropical Research Institute2, Duke University3, University of Florida4, Louisiana State University5, National Autonomous University of Mexico6, National Marine Fisheries Service7, Rhodes College8, Commonwealth Scientific and Industrial Research Organisation9, University of Western Australia10, George Mason University11
TL;DR: In this paper, the authors synthesize findings to date from the world's largest and longest-running experimental study of habitat fragmentation, located in central Amazonia, and synthesize the results to date.
TL;DR: In this paper, the authors proposed to select and develop wheat genotypes with heat-resistant proteins to improve grain yield under heat stress by selecting genotypes for grain size and rate of grain filling.
Abstract: Ambient temperatures have increased since the beginning of the century and are predicted to continue rising under climate change. Such increases in temperature can cause heat stress: a severe threat to wheat production in many countries, particularly when it occurs during reproductive and grain-filling phases. Heat stress reduces plant photosynthetic capacity through metabolic limitations and oxidative damage to chloroplasts, with concomitant reductions in dry matter accumulation and grain yield. Genotypes expressing heat shock proteins are better able to withstand heat stress as they protect proteins from heat-induced damage. Heat tolerance can be improved by selecting and developing wheat genotypes with heat resistance. Wheat pre-breeding and breeding may be based on secondary traits like membrane stability, photosynthetic rate and grain weight under heat stress. Nonetheless, improvement in grain yield under heat stress implies selecting genotypes for grain size and rate of grain filling. Integrating ph...
TL;DR: A classification of translocations based on specific genetic goals for both threatened species and ecological restoration is provided, separating targets based on ‘genetic rescue’ of current population fitness from those focused on maintaining adaptive potential.
Abstract: Translocations are being increasingly proposed as a way of conserving biodiversity, particularly in the management of threatened and keystone species, with the aims of maintaining biodiversity and ecosystem function under the combined pressures of habitat fragmentation and climate change. Evolutionary genetic considerations should be an important part of translocation strategies, but there is often confusion about concepts and goals. Here, we provide a classification of translocations based on specific genetic goals for both threatened species and ecological restoration, separating targets based on ‘genetic rescue’ of current population fitness from those focused on maintaining adaptive potential. We then provide a framework for assessing the genetic benefits and risks associated with translocations and provide guidelines for managers focused on conserving biodiversity and evolutionary processes. Case studies are developed to illustrate the framework.
TL;DR: Evidence that more P-efficient plants can be developed by modifying root growth and architecture, through manipulation of root exudates or by managing plant-microbial associations such as arbuscular mycorrhizal fungi and microbial inoculants is critically reviewed.
Abstract: Background
Agricultural production is often limited by low phosphorus (P) availability. In developing countries, which have limited access to P fertiliser, there is a need to develop plants that are more efficient at low soil P. In fertilised and intensive systems, P-efficient plants are required to minimise inefficient use of P-inputs and to reduce potential for loss of P to the environment.
TL;DR: Business issues that need to be considered when selecting an appropriate modelling approach for trial are discussed and classification tables and process flow diagrams are presented to assist industry and research personnel select appropriate prognostic models for predicting the remaining useful life of engineering assets within their specific business environment.
TL;DR: This integrated analysis of the mitochondrial transcriptome reveals unexpected complexity in the regulation, expression, and processing of mitochondrial RNA and provides a resource for future studies of mitochondrial function.
University of Copenhagen1, University of California, Berkeley2, Technical University of Denmark3, Estonian Biocentre4, Imperial College London5, University of Cambridge6, Chinese Academy of Sciences7, Stanford University8, Murdoch University9, National Autonomous University of Mexico10, University of Western Australia11, Kitasato University12, University of Bern13, University of Chicago14, University of Toulouse15, Leiden University16, University College London17, Griffith University18, Max Planck Society19, University of British Columbia20, Estonian Academy of Sciences21
TL;DR: It is shown that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago, which is separate from the one that gave rise to modern Asians 25, thousands of years ago.
Abstract: We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.
TL;DR: It appears that fitness and football-specific performance can be improved equally with SSG and generic training drills, and the variation in exercise intensity during SSGs can also be improved with consistent coach encouragement but it is still more variable than traditional generic training methods.
Abstract: Small-sided games (SSGs) are played on reduced pitch areas, often using modified rules and involving a smaller number of players than traditional football. These games are less structured than traditional fitness training methods but are very popular training drills for players of all ages and levels. At present, there is relatively little information regarding how SSGs can best be used to improve physical capacities and technical or tactical skills in footballers. However, many prescriptive variables controlled by the coach can influence the exercise intensity during SSGs. Coaches usually attempt to change the training stimulus in SSGs through altering the pitch area, player number, coach encouragement, training regimen (continuous vs interval training), rules and the use of goalkeepers. In general, it appears that SSG exercise intensity is increased with the concurrent reduction in player number and increase in relative pitch area per player. However, the inverse relationship between the number of players in each SSG and exercise intensity does not apply to the time-motion characteristics. Consistent coach encouragement can also increase training intensity, but most rule changes do not appear to strongly affect exercise intensity. The variation of exercise intensity measures are lower in smaller game formats (e.g. three vs three) and have acceptable reproducibility when the same game is repeated between different training sessions or within the same session. The variation in exercise intensity during SSGs can also be improved with consistent coach encouragement but it is still more variable than traditional generic training methods. Other studies have also shown that SSGs containing fewer players can exceed match intensity and elicit similar intensities to both long- and short-duration high-intensity interval running. It also appears that fitness and football-specific performance can be improved equally with SSG and generic training drills. Future research is required to examine the optimal periodization strategies of SSGs training for the long-term development of physiological capacity, technical skill and tactical proficiency.
TL;DR: Population surveillance of youth physical activity is strongly recommended and those involved in developing and undertaking this task should consider the three identified shortlisted instruments and evaluate their appropriateness for application within their national context.
Abstract: The assessment of physical activity is an essential part of understanding patterns and influences of behaviour, designing interventions, and undertaking population surveillance and monitoring, but it is particularly problematic when using self-report instruments with young people. This study reviewed available self-report physical activity instruments developed for use with children and adolescents to assess their suitability and feasibility for use in population surveillance systems, particularly in Europe. Systematic searches and review, supplemented by expert panel assessment. Papers (n = 437) were assessed as potentially relevant; 89 physical activity measures were identified with 20 activity-based measures receiving detailed assessment. Three received support from the majority of the expert group: Physical Activity Questionnaire for Children/Adolescents (PAQ-C/PAQ-A), Youth Risk Behaviour Surveillance Survey (YRBS), and the Teen Health Survey. Population surveillance of youth physical activity is strongly recommended and those involved in developing and undertaking this task should consider the three identified shortlisted instruments and evaluate their appropriateness for application within their national context. Further development and testing of measures suitable for population surveillance with young people is required.