University of Western Australia

About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.

The transcriptional landscape of age in human peripheral blood

Abstract: Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

COVID-19: potential effects on Chinese citizens’ lifestyle and travel

Abstract: The 2019 novel coronavirus (COVID-19) outbreak is projected to have adverse consequences on the global tourism and hospitality industry. This paper aims to examine how the outbreak may alter Chinese tourists’ lifestyle choices, travel behaviour and tourism preferences in the short and long term.,This paper is based on the synthesis of news broadcasted by several media outlets to be supported by an overview of the related literature on tourism marketing, tourism management and tourist behaviour. The authors’ experiences investigating trends in tourism and hospitality at the local and international level have also contributed to the study.,This paper predicts that COVID-19 will likely affect Chinese travellers’ consumption patterns, such as the growing popularity of free and independent travel, luxury trips and health and wellness tourism. New forms of tourism including slow tourism and smart tourism may also drive future tourism activities. Such changes are likely to force businesses to reconsider their service designs and distribution channels.,While Chinese and other potential visitors rethink how they travel, professionals, too, should reflect upon how to bring positive or negative changes to the tourism industry following this pandemic. Subsequent research should also consider how to mitigate the effects of similar public health crises in the future.,Recommendations for industry practitioners and policymakers focus on tailoring travel arrangements to tourists’ backgrounds. The suggestions may help to alleviate outbreak-related stress, offer travellers newly enriching experiences and partially mitigate the effects of COVID-19 on the tourism and hospitality industry. These recommendations can also apply more broadly to global tourist markets.,The COVID-19 outbreak has already brought significant impacts to nearly every society and industry. Tourism scholars and practitioners should carefully consider this tragedy and how it may inform industry and social practices. This and other public health crises represent sterling opportunities to view the industry holistically in terms of its effects on the environment, climate and travellers themselves.,This paper presumably represents a frontier study, critically examining the possible impacts of COVID-19 on Chinese travellers’ consumption patterns and how the tourism and hospitality industry may respond to such changes in the future.,预计2019年新型冠状病毒（COVID-19）爆发将对全球旅游和酒店业产生不利影响。本文预测, COVID-19可能会影响中国旅客的消费方式, 例如自由行, 豪华旅行以及健康与养生旅游的普及。包括慢速旅游和智能旅游在内的新型旅游形式也可能推动未来的旅游活动。这种变化可能促使企业重新考虑其服务设计和分销渠道。针对行业从业者和政策制定者的建议着重于根据游客的背景和需求量身定制旅行安排。我们的建议可能有助于减轻与疫情暴发导致的压力, 为旅行者提供全新的丰富体验, 并从一定程度减轻COVID-19对旅游业和酒店业的影响。这些建议还可以更广泛地应用于全球旅游市场。,COVID-19, 生活方式 旅游行为 灾后 集体主义倾向 中国,El impacto del COVID-19 se preve importante en la actividad turistica global y en la industria de la hosteleria. Este articulo predice que el COVID-19 afectara con probabilidad alta los patrones de consumo de los viajeros chinos, incluyendo los cada vez mas populares viajes comprados directamente por los consumidores chinos, en el segmento del lujo, y el turismo de salud y belleza. Nuevas formas de turismo, incluyendo el slow tourism, y el turismo responsable pueden convertirse en importantes tendencias de futuro igualmente. Dichos cambios llevaran con cierta seguridad a la industria a reconsiderar y adaptar su oferta de servicios en este sector, en particular su diseno y los canales de distribucion utilizados. Las recomendaciones para la industria y los responsables de la politica turistica se alinean con una mayor proximidad de la oferta a los gustos cambiantes del consumidor. Dichas acciones ayudaran a reducir fricciones y fallos en la definicion del negocio turistico, ofreciendo a los viajeros nuevas y enriquecedoras experiencias, asi como podran mitigar en parte los efectos adversos estimados del COVID-19, los cuales son relevantes a dia de hoy. Asi mismo, dichas recomendaciones son aplicables de una manera mas global a la industria del turismo y la hospitalidad en el mercado mundial.,COVID-19, Estilo de vida, Conducta del viajero, Post-desastre, Orientacion collectivista, China

Evolved glyphosate-resistant weeds around the world: lessons to be learnt

Abstract: Glyphosate is the world's most important herbicide, with many uses that deliver effective and sustained control of a wide spectrum of unwanted (weedy) plant species. Until recently there were relatively few reports of weedy plant species evolving resistance to glyphosate. Since 1996, the advent and subsequent high adoption of transgenic glyphosate-resistant crops in the Americas has meant unprecedented and often exclusive use of glyphosate forweedcontroloververylarge areas.Consequently, in regionsoftheUSA wheretransgenic glyphosate- resistant crops dominate, there are now evolved glyphosate-resistant populations of the economically damaging weed species Ambrosia artemissifolia L., Ambrosia trifida L., Amaranthus palmeri SW atson,Amaranthus rudis JD Sauer, Amaranthus tuberculatus (Moq) JD Sauer and various Conyza and Lolium spp. Likewise, in areas of transgenic glyphosate-resistant crops in Argentina and Brazil, there are now evolved glyphosate-resistant populations ofSorghum halepense (L.) Pers andEuphorbia heterophylla L. respectively. As transgenic glyphosate- resistant crops will remain very popular with producers, it is anticipated that glyphosate-resistant biotypes of other prominent weed species will evolve over the next few years. Therefore, evolved glyphosate-resistant weeds are a major risk for the continued success of glyphosate and transgenic glyphosate-resistant crops. However, glyphosate-resistant weeds are not yet a problem in many parts of the world, and lessons can be learnt and actions taken to achieve glyphosate sustainability. A major lesson is that maintenance of diversity in weed management systems is crucial for glyphosate to be sustainable. Glyphosate is essential for present and future world food production, and action to secure its sustainability for future gene rations is ag lobal imperative.  2008 Society of Chemical Industry