University of Western Australia

About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Abstract: To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

Twenty-three unsolved problems in hydrology (UPH)–a community perspective

Abstract: This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focused on the process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come.

Ridge-Furrow Mulching Systems—An Innovative Technique for Boosting Crop Productivity in Semiarid Rain-Fed Environments

Abstract: Increasing food demands by a growing human population require substantial increases in crop productivity. In rain-fed arid and semiarid areas where the water supply is limited, an increase in the precipitation use efficiency (PUE) is the key to reach this goal. This chapter examines the scientific basis of a ridge-furrow mulching system (RF system) for increasing PUE, and summarizes the effects of this system on crop performance, microclimates, soil attributes, and environmental sustainability. Studies have shown that using crop straw, plastic film, or gravel–sand materials to mulch the soil surface significantly reduces the evaporation of soil moisture, increases water availability to crop plants, and decreases soil erosion caused by wind and water. Plastic mulching increases topsoil temperature during cool spring, promoting plant growth; during hot summer, straw mulching can moderate soil temperature, preventing the topsoil from reaching temperatures that inhibit plant growth. Ridge furrows with plastic mulching on the ridges and crop straw covering the furrows channel water to the furrows, and enhance soil water infiltration and water availability to the crop. Microclimates under mulched ridges and furrows favor soil microbial activity, increase soil biodiversity, and improve environmental benefits. The effectiveness of ridge-furrow systems is reflected in increased crop yields (20–180%) compared with that of the conventional-flat planting. Although more research is required to document physiochemical strengths, technique details and potential drawbacks, and more importantly to define long-term sustainability, we strongly suggest that RF systems are an innovative approach for increasing crop water availability, improving soil productivity, and enhancing food security for arid and semiarid rain-fed areas.

Common infections in diabetes: pathogenesis, management and relationship to glycaemic control.

Abstract: Specific defects in innate and adaptive immune function have been identified in diabetic patients in a range of in vitro studies. However, the relevance of these findings to the integrated response to infection in vivo remains unclear, especially in patients with good glycaemic control. Vaccine efficacy seems adequate in most diabetic patients, but those with type 1 diabetes and high glycosylated haemoglobin levels are most likely to exhibit hypo-responsiveness. While particular infections are closely associated with diabetes, this is usually in the context of extreme metabolic disturbances such as ketoacidosis. The link between glycaemic control and the risk of common community-acquired infections is less well established but could be clarified if infection data from large community-based observational or intervention studies were available. The relationship between hospital-acquired infections and diabetes is well recognized, particularly among post-operative cardiac and critically ill surgical patients in whom intensive insulin therapy improves clinical outcome independent of glycaemia. Nevertheless, further research is needed to improve our understanding of the role of diabetes and glycaemic control in the pathogenesis and management of community- and hospital-acquired infections.