scispace - formally typeset
Search or ask a question
Institution

University of Western Australia

EducationPerth, Western Australia, Australia
About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.


Papers
More filters
Journal ArticleDOI
TL;DR: Modelling with Stakeholders is updated and builds on Voinov and Bousquet, 2010, and structured mechanisms to examine and account for human biases and beliefs in participatory modelling are suggested.
Abstract: This paper updates and builds on 'Modelling with Stakeholders' Voinov and Bousquet, 2010 which demonstrated the importance of, and demand for, stakeholder participation in resource and environmental modelling. This position paper returns to the concepts of that publication and reviews the progress made since 2010. A new development is the wide introduction and acceptance of social media and web applications, which dramatically changes the context and scale of stakeholder interactions and participation. Technology advances make it easier to incorporate information in interactive formats via visualization and games to augment participatory experiences. Citizens as stakeholders are increasingly demanding to be engaged in planning decisions that affect them and their communities, at scales from local to global. How people interact with and access models and data is rapidly evolving. In turn, this requires changes in how models are built, packaged, and disseminated: citizens are less in awe of experts and external authorities, and they are increasingly aware of their own capabilities to provide inputs to planning processes, including models. The continued acceleration of environmental degradation and natural resource depletion accompanies these societal changes, even as there is a growing acceptance of the need to transition to alternative, possibly very different, life styles. Substantive transitions cannot occur without significant changes in human behaviour and perceptions. The important and diverse roles that models can play in guiding human behaviour, and in disseminating and increasing societal knowledge, are a feature of stakeholder processes today. Display Omitted Participatory modelling has become mainstream in resource and environmental management.We review recent contributions to participatory environmental modelling to identify the tools, methods and processes applied.Global internet connectivity, social media and crowdsourcing create opportunities for participatory modelling.We suggest structured mechanisms to examine and account for human biases and beliefs in participatory modelling.Advanced visualization tools, gaming, and virtual environments improve communication with stakeholders.

404 citations

Journal ArticleDOI
TL;DR: In this article, the differences in the microstructure, defects and mechanical behavior of porous structures from a β-type Ti 24Nb 4Zr 8Sn manufactured by electron beam melting (EBM) and selective laser melting (SLM) were investigated and correlated to the compressive mechanical and fatigue properties.

404 citations

Journal ArticleDOI
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Abstract: Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-3p associates with both elevated serum exosomal miR-214-3p and reduced bone formation in elderly women with fractures and in ovariectomized (OVX) mice. Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation that is rescued by osteoclast-targeted antagomir-214-3p treatment. We further demonstrate that osteoclast-derived exosomal miR-214-3p is transferred to osteoblasts to inhibit osteoblast activity in vitro and reduce bone formation in vivo. Moreover, osteoclast-targeted miR-214-3p inhibition promotes bone formation in ageing OVX mice. Collectively, our results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation. Inhibition of miR-214-3p in osteoclasts may be a strategy for treating skeletal disorders involving a reduction in bone formation.

403 citations

Journal ArticleDOI
TL;DR: In this paper, a latent trait measurement model in which ordered response categories are both parameterized and scored with successive integers is investigated and applied to a summated rating or Likert questionnaire.
Abstract: A latent trait measurement model in which ordered response categories are both parameterized and scored with successive integers is investigated and applied to a summated rating or Likert ques tionnaire In addition to each category, each item of the questionnaire and each subject are para meterized in the model; and maximum likelihood estimates for these parameters are derived Among the features of the model which make it attractive for applications to Likert questionnaires is that the total score is a sufficient statistic for a subject's at titude measure Thus, the model provides a formal ization of a familiar and practical procedure for measuring attitudes

403 citations


Authors

Showing all 29972 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
Cornelia M. van Duijn1831030146009
Kay-Tee Khaw1741389138782
Steven N. Blair165879132929
David W. Bates1591239116698
Mark E. Cooper1581463124887
David Cameron1541586126067
Stephen T. Holgate14287082345
Jeremy K. Nicholson14177380275
Xin Chen1391008113088
Graeme J. Hankey137844143373
David Stuart1361665103759
Joachim Heinrich136130976887
Carlos M. Duarte132117386672
David Smith1292184100917
Network Information
Related Institutions (5)
University of Queensland
155.7K papers, 5.7M citations

98% related

University of Melbourne
174.8K papers, 6.3M citations

97% related

University of Sydney
187.3K papers, 6.1M citations

97% related

University of British Columbia
209.6K papers, 9.2M citations

92% related

University of Manchester
168K papers, 6.4M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023138
2022656
20215,967
20205,589
20195,452
20184,923