University of Western Australia

About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

Abstract: Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. There is therefore considerable interest in generating efficient approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. It aims to provide evidence-based recommendations for primary prevention of food allergy. A wide range of antenatal, perinatal, neonatal, and childhood strategies were identified and their effectiveness assessed and synthesized in a systematic review. Based on this evidence, families can be provided with evidence-based advice about preventing food allergy, particularly for infants at high risk for development of allergic disease. The advice for all mothers includes a normal diet without restrictions during pregnancy and lactation. For all infants, exclusive breastfeeding is recommended for at least first 4-6 months of life. If breastfeeding is insufficient or not possible, infants at high-risk can be recommended a hypoallergenic formula with a documented preventive effect for the first 4 months. There is no need to avoid introducing complementary foods beyond 4 months, and currently, the evidence does not justify recommendations about either withholding or encouraging exposure to potentially allergenic foods after 4 months once weaning has commenced, irrespective of atopic heredity. There is no evidence to support the use of prebiotics or probiotics for food allergy prevention.

An Integrative Approach to Leader Development: Connecting Adult Development, Identity, and Expertise

Abstract: Part 1. Overview and Purpose. 1. Introduction. Part 2. Perspectives from Adult Development Literature. 2. Accelerating Leader Development. 3. Leader Development as Adult Development. 4. Understanding Personal Trajectories of Development. Part 3. Fundamental Aspects of Adult Development. 5. Identity Development. 6. Moral Development. 7. Epistemic Cognition, Reflective Judgment, and Critical Reasoning. Part 4. Learning-based Approaches to Leadership. 8. Mental Models: Leadership as a Set of Cognitive Frames. 9. Expertise - Leadership as a Set of Skills. 10. Leader Development Through Learning from Experience. 11. Leadership Development and Teams. Part 5. Integrative Theory of Leader Development. 12. General Overview of Developing the Expert Leader. 13. Identity Processes in Leader Development. 14. Adult Development Processes in Leader Development. Part 6. Future Directions. 15. Research Needs and Practical Implications. References. Appendix A: Glossary of Terms. Appendix B: Measurement Tools.

Major genes for Na+ exclusion, Nax1 and Nax2 (wheat HKT1;4 and HKT1;5), decrease Na+ accumulation in bread wheat leaves under saline and waterlogged conditions

Abstract: Two major genes for Na(+) exclusion in durum wheat, Nax1 and Nax2, that were previously identified as the Na(+) transporters TmHKT1;4-A2 and TmHKT1;5-A, were transferred into bread wheat in order to increase its capacity to restrict the accumulation of Na(+) in leaves. The genes were crossed from tetraploid durum wheat (Triticum turgidum ssp. durum) into hexaploid bread wheat (Triticum aestivum) by interspecific crossing and marker-assisted selection for hexaploid plants containing one or both genes. Nax1 decreased the leaf blade Na(+) concentration by 50%, Nax2 decreased it by 30%, and both genes together decreased it by 60%. The signature phenotype of Nax1, the retention of Na(+) in leaf sheaths resulting in a high Na(+) sheath:blade ratio, was found in the Nax1 lines. This conferred an extra advantage under a combination of waterlogged and saline conditions. The effect of Nax2 on lowering the Na(+) concentration in bread wheat was surprising as this gene is very similar to the TaHKT1;5-D Na(+) transporter already present in bread wheat, putatively at the Kna1 locus. The results indicate that both Nax genes have the potential to improve the salt tolerance of bread wheat.

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Abstract: Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.

XCOLD GASS: The Complete IRAM 30 m Legacy Survey of Molecular Gas for Galaxy Evolution Studies

Abstract: We introduce xCOLD GASS, a legacy survey providing a census of molecular gas in the local universe. Building on the original COLD GASS survey, we present here the full sample of 532 galaxies with CO (1–0) measurements from the IRAM 30 m telescope. The sample is mass-selected in the redshift interval $0.01\lt z\lt 0.05$ from the Sloan Digital Sky Survey (SDSS) and therefore representative of the local galaxy population with ${M}_{* }\ \gt {10}^{9}\,{M}_{\odot }$. The CO (1–0) flux measurements are complemented by observations of the CO (2–1) line with both the IRAM 30 m and APEX telescopes, H i observations from Arecibo, and photometry from SDSS, WISE, and GALEX. Combining the IRAM and APEX data, we find that the ratio of CO (2–1) to CO (1–0) luminosity for integrated measurements is ${r}_{21}=0.79\pm 0.03$, with no systematic variations across the sample. The CO (1–0) luminosity function is constructed and best fit with a Schechter function with parameters ${L}_{\mathrm{CO}}^{* }=(7.77\pm 2.11)\times {10}^{9}\,{\rm{K}}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{pc}}^{2}$, ${\phi }^{* }=(9.84\pm 5.41)\times {10}^{-4}\,{\mathrm{Mpc}}^{-3}$, and $\alpha =-1.19\pm 0.05$. With the sample now complete down to stellar masses of 109 ${M}_{\odot }$, we are able to extend our study of gas scaling relations and confirm that both molecular gas fractions (${f}_{{{\rm{H}}}_{2}}$) and depletion timescale (${t}_{\mathrm{dep}}({{\rm{H}}}_{2})$) vary with specific star formation rate (or offset from the star formation main sequence) much more strongly than they depend on stellar mass. Comparing the xCOLD GASS results with outputs from hydrodynamic and semianalytic models, we highlight the constraining power of cold gas scaling relations on models of galaxy formation.