University of Western Australia

About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.

Structure, mechanism and regulation of pyruvate carboxylase.

Abstract: effector domain. In the presence of the allosteric effector, acetyl- CoA, the biotin moiety transfers the carboxy group between the biotin carboxylase domain active site on one polypeptide chain and the carboxyltransferase active site on the adjacent antiparallel polypeptide chain. In addition, thebonafiderole of PCin the non- gluconeogenic tissues has been studied using a combination of classical biochemistry and genetic approaches. The first cloning of the promoter of the PC gene in mammals and subsequent transcriptional studies reveal some key cognate transcription factors regulating tissue-specific expression. The present review summarizes these advances and also offers some prospects in terms of future directions for the study of this important enzyme.

Perturbation of Indole-3-Butyric Acid Homeostasis by the UDP-Glucosyltransferase UGT74E2 Modulates Arabidopsis Architecture and Water Stress Tolerance

Abstract: Reactive oxygen species and redox signaling undergo synergistic and antagonistic interactions with phytohormones to regulate protective responses of plants against biotic and abiotic stresses. However, molecular insight into the nature of this crosstalk remains scarce. We demonstrate that the hydrogen peroxide-responsive UDP-glucosyltransferase UGT74E2 of Arabidopsis thaliana is involved in the modulation of plant architecture and water stress response through its activity toward the auxin indole-3-butyric acid (IBA). Biochemical characterization of recombinant UGT74E2 demonstrated that it strongly favors IBA as a substrate. Assessment of indole-3-acetic acid (IAA), IBA, and their conjugates in transgenic plants ectopically expressing UGT74E2 indicated that the catalytic specificity was maintained in planta. In these transgenic plants, not only were IBA-Glc concentrations increased, but also free IBA levels were elevated and the conjugated IAA pattern was modified. This perturbed IBA and IAA homeostasis was associated with architectural changes, including increased shoot branching and altered rosette shape, and resulted in significantly improved survival during drought and salt stress treatments. Hence, our results reveal that IBA and IBA-Glc are important regulators of morphological and physiological stress adaptation mechanisms and provide molecular evidence for the interplay between hydrogen peroxide and auxin homeostasis through the action of an IBA UGT.

Empirical studies of self-employment

Abstract: This paper presents a review of empirical studies of self-employment for the Australian, Canadian, Dutch, UK and US labour markets. Both cross-sectional and longitudinal studies are analysed. Analyses using cross-sectional data examine the propensity to be self-employed at any one point in time, whereas longitudinal studies focus on the transition into self-employment from wage/salary employment and the survival rate in this state over time. Various hypotheses advanced in the economics and sociology literatures on self-employment are tested. These include the relationship between managerial ability and the propensity to be self-employed and the impact of financial constraints on entry into self-employment stressed in economic models of entrepreneurship, and the relationships between self-employment choice and the nature of the work and group characteristics (e.g., ethnic enclaves) stressed in sociological models of entrepreneurship. The evidence shows that self-employment outcomes are significantly affected by factors such as individual abilities, family background, occupational status, liquidity constraints and ethnic enclaves.

Optimal Time Lags in Panel Studies

Abstract: Cross-lagged regression coefficients are frequently used to test hypotheses in panel designs. However, these coefficients have particular properties making them difficult to interpret. In particular, cross-lagged regression coefficients may vary, depending on the respective time lags between different sets of measurement occasions. This article introduces the concept of an optimal time lag. Further, it is demonstrated that optimal time lags in panel studies are related to the stabilities of the variables investigated, and that in unidirectional systems, they may be unrelated to the size of possible true effects. The results presented also suggest that optimal time lags for panel designs are usually quite short. Implications are (a) that interpreting cross-lagged regression coefficients requires taking the time lag between measurement occasions into account, and (b) that in much research, far shorter time lags than those frequently found in the literature are justifiable, and we call for more "shortitudinal" studies in the future.