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Institution

University of Western Australia

EducationPerth, Western Australia, Australia
About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.


Papers
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Journal ArticleDOI
01 Oct 2012-Geology
TL;DR: In this paper, the authors use the difference between the measured crystallization ages (CA) of individual zircon grains present in the sediment and the depositional age (DA) of the sedi-ment to constrain the tectonic setting in which the sediment was deposited.
Abstract: Detrital zircon spectra refl ect the tectonic setting of the basin in which they are deposited. Convergent plate margins are charac-terized by a large proportion of zircon ages close to the depositional age of the sediment, whereas sediments in collisional, extensional and intracratonic settings contain greater proportions with older ages that refl ect the history of the underlying basement. These differences can be resolved by plotting the distribution of the difference between the measured crystallization ages (CA) of individual zircon grains present in the sediment and the depositional age (DA) of the sedi-ment. Application of this approach to successions where the original nature of the basin and/or the link to source are no longer preserved constrains the tectonic setting in which the sediment was deposited.INTRODUCTION Detrital zircons are a minor constituent of clastic sedimentary rocks, yet their physiochemical resilience and high concentrations of certain key trace elements means that they have become an important phase in sedimentary provenance analysis and in crustal evolution studies (e.g., Cawood et al., 2007b; Hawkesworth et al., 2010). Large numbers of in situ, high precision analyses of both igneous and detrital zircons are now available, and a striking feature of the zircon record is that it clusters into peaks of crystallization ages (Condie et al., 2009). Compilations of crys-tallization ages for detrital and igneous zircons show remarkably similar patterns of peaks and troughs, although with some variation in the rela-tive amplitude of the peaks (Condie et al., 2009). This coincidence sug-gests that the sedimentary record is a valid representation of the magmatic record (Hawkesworth et al., 2010).We establish that detrital zircon spectra have distinctive age distribu-tion patterns that refl ect the tectonic setting of the basin in which they are deposited. These patterns are principally controlled by (i) the volumes of magma generated in each tectonic setting and their preservation poten-tial, (ii) the ease with which magmatic and detrital zircons of various ages and origins become incorporated into the sedimentary record, and (iii) the record of old zircons incorporated into the sediment. These in turn provide a framework that can be used to constrain the tectonic setting of sedimen-tary packages. This approach distinguishes between three tectonic settings (i.e., convergent, collisional, and extensional), and it is most sensitive when the depositional age of the sediment investigated is well constrained. Basin setting will evolve with tectonic regime; for example, arc-continent or continent-continent collision will result in the evolution of convergent and extensional basins into collisional foreland basins. Hence the three settings distinguished herein are end-members, and the zircon age patterns associ-ated with each show a spectrum of distributions that merge and overlap rather than defi ne discrete fi elds. Discriminant plots developed for igneous rock geochemistry (e.g., Pearce and Cann, 1973) or sediment framework modes (e.g., Dickinson and Suczek, 1979) often have diffuse boundaries or overlap between fi elds, but remain important approaches in understanding and constraining tectonic setting. Equally important, exceptions to simple end-member classifi cations can provide insight into subtleties of tectonic process, such as outlined below for Avalonia in eastern North America.

969 citations

Journal ArticleDOI
TL;DR: This review examines the response of the magnetic resonance visible iron in tissue that produces signal changes in both magnitude and phase images that seem to correlate with brain iron content, but still have not been successfully exploited to accurately and precisely quantify brain iron.

955 citations

Journal ArticleDOI
Anubha Mahajan1, Min Jin Go, Weihua Zhang2, Jennifer E. Below3  +392 moreInstitutions (104)
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Abstract: To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

954 citations

Journal ArticleDOI
TL;DR: Most adverse morbid outcomes in high-risk patients undergoing major abdominal surgery are not reduced by use of combined epidural and general anaesthesia and postoperative epidural analgesia, however, the improvement in analgesIA, reduction in respiratory failure, and the low risk of serious adverse consequences suggest that many high- risk patients undergo major intra-abdominal surgery will receive substantial benefit from combined general and epidural anaesthesia intraoperatively with continuing postoperative analgesia.

948 citations

Journal ArticleDOI
TL;DR: To examine the hypothesis that sleep apnoea is a risk factor for ischaemic heart disease, overnight polysomnography was performed in 101 unselected male survivors of acute myocardial infarction aged less than 66 yr and in 53 male subjects of similar age without evidence of ischaemia heart disease.

946 citations


Authors

Showing all 29972 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
Cornelia M. van Duijn1831030146009
Kay-Tee Khaw1741389138782
Steven N. Blair165879132929
David W. Bates1591239116698
Mark E. Cooper1581463124887
David Cameron1541586126067
Stephen T. Holgate14287082345
Jeremy K. Nicholson14177380275
Xin Chen1391008113088
Graeme J. Hankey137844143373
David Stuart1361665103759
Joachim Heinrich136130976887
Carlos M. Duarte132117386672
David Smith1292184100917
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023138
2022656
20215,967
20205,589
20195,452
20184,923