Institution
University of Western Australia
Education•Perth, Western Australia, Australia•
About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.
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TL;DR: A membrane-protein fraction that reconstituted high MscCa activity and showed an abundance of a protein that had a relative molecular mass of 80,000 (Mr 80K) indicate that TRPC1 is a component of the vertebrate MSCCa, which is gated by tension developed in the lipid bilayer, as is the case in various prokaryotic mechanosensitive (Ms) channels.
Abstract: The mechanosensitive cation channel (MscCa) transduces membrane stretch into cation (Na+, K+, Ca2+ and Mg2+) flux across the cell membrane, and is implicated in cell-volume regulation1, cell locomotion2, muscle dystrophy3 and cardiac arrhythmias4. However, the membrane protein(s) that form the MscCa in vertebrates remain unknown. Here, we use an identification strategy that is based on detergent solubilization of frog oocyte membrane proteins, followed by liposome reconstitution and evaluation by patch-clamp5. The oocyte was chosen because it expresses the prototypical MscCa (≥107MscCa/oocyte)6 that is preserved in cytoskeleton-deficient membrane vesicles7. We identified a membrane-protein fraction that reconstituted high MscCa activity and showed an abundance of a protein that had a relative molecular mass of 80,000 (Mr 80K). This protein was identified, by immunological techniques, as the canonical transient receptor potential channel 1 (TRPC1)8,9,10. Heterologous expression of the human TRPC1 resulted in a >1,000% increase in MscCa patch density, whereas injection of a TRPC1-specific antisense RNA abolished endogenous MscCa activity. Transfection of human TRPC1 into CHO-K1 cells also significantly increased MscCa expression. These observations indicate that TRPC1 is a component of the vertebrate MscCa, which is gated by tension developed in the lipid bilayer, as is the case in various prokaryotic mechanosensitive (Ms) channels11.
606 citations
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North-West University1, University of Southern Denmark2, New York City Department of Health and Mental Hygiene3, Centers for Disease Control and Prevention4, Paris Descartes University5, Ottawa Hospital Research Institute6, Eduardo Mondlane University7, University of Glasgow8, French Institute of Health and Medical Research9, University of Western Australia10, University of Valencia11, The George Institute for Global Health12, Ghent University Hospital13, University of Perugia14, Menzies Research Institute15, Oslo University Hospital16, Shanghai Jiao Tong University17
TL;DR: The Commission has identified ten essential and achievable goals and ten accompanying, mutually additive, and synergistic key actions that—if implemented effectively and broadly—will make substantial contributions to the management of blood pressure globally.
604 citations
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TL;DR: This work suggests a framework for incorporating threshold models that reflects an emphasis on applicability to decision making and management on relatively short timescales and in human-impacted systems.
Abstract: The recognition that a system can appear resilient to changes in the environment, only to reach a critical threshold of rapid and unexpected change, is spurring work to apply threshold models in conservation and restoration. Here we address the relevance of threshold models to habitat management. Work to date indicates these concepts are highly applicable: human impacts can widen the range of habitats where threshold dynamics occur and shift communities into new states that are difficult to reverse. However, in many applied settings, threshold concepts are being adopted without evaluation of evidence and uncertainty. We suggest a framework for incorporating threshold models that reflects an emphasis on applicability to decision making and management on relatively short timescales and in human-impacted systems.
604 citations
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TL;DR: The use of image analysis in the automated diagnosis of pathology (with particular reference to diabetic retinopathy) is reviewed, as well as its role in defining and performing quantitative measurements of vascular topography, and how these entities are based on 'optimisation' principles.
602 citations
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TL;DR: In this article, the authors develop methods for analysing the interaction or dependence between points in a spatial point pattern, when the pattern is spatially inhomogeneous, using an analogue of the K-function.
Abstract: We develop methods for analysing the ‘interaction’ or dependence between points in a spatial point pattern, when the pattern is spatially inhomogeneous. Completely non-parametric study of interactions is possible using an analogue of the K-function. Alternatively one may assume a semi-parametric model in which a (parametrically specified) homogeneous Markov point process is subjected to (non-parametric) inhomogeneous independent thinning. The effectiveness of these approaches is tested on datasets representing the positions of trees in forests.
601 citations
Authors
Showing all 29972 results
Name | H-index | Papers | Citations |
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Nicholas G. Martin | 192 | 1770 | 161952 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Steven N. Blair | 165 | 879 | 132929 |
David W. Bates | 159 | 1239 | 116698 |
Mark E. Cooper | 158 | 1463 | 124887 |
David Cameron | 154 | 1586 | 126067 |
Stephen T. Holgate | 142 | 870 | 82345 |
Jeremy K. Nicholson | 141 | 773 | 80275 |
Xin Chen | 139 | 1008 | 113088 |
Graeme J. Hankey | 137 | 844 | 143373 |
David Stuart | 136 | 1665 | 103759 |
Joachim Heinrich | 136 | 1309 | 76887 |
Carlos M. Duarte | 132 | 1173 | 86672 |
David Smith | 129 | 2184 | 100917 |