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Institution

University of Westminster

EducationLondon, United Kingdom
About: University of Westminster is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Politics. The organization has 2944 authors who have published 8426 publications receiving 200236 citations. The organization is also known as: Westminster University & Royal Polytechnic Institution.


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Journal ArticleDOI
TL;DR: This is the first report in which HPA has been shown to bind O-GlcNAcylated transcription factors, which represents a new means by which H PA differentiates cancer cells with an aggressive metastatic phenotype.
Abstract: There has been considerable interest in understanding the epitopes that bind the lectin Helix pomatia agglutinin (HPA) in breast cancer as the lectin has been shown to identify glycosylation changes associated with the development of metastatic disease. HPA has previously been shown to recognize aberrant O-linked α-N-acetylgalactosamine (GalNAcα)/mucin glycosylation in cancer, including exposed Tn epitopes. However, recent glycan-array analysis reported that diverse epitopes are also recognized by the lectin, e.g. consortium for functional glycomics (CFG) data: GalNAcα1,3Gal; β-GalNAc; GlcNAcβ1,4Gal. The intriguing observations from the CFG array led to this study, in which HPA-binding epitopes were localized and characterized in an in vitro model of breast cancer metastasis. HMT3522 (benign disease), BT474 (primary cancer) and T47D/MCF7 (metastatic cancer) cells were assessed in confocal microscopy-based co-localization studies and a glycoproteomic analysis based on 2-dimensional electrophoresis (2DE), western blotting and mass spectrometry was adopted. HPA binding correlated with levels of integrin α6, transcription factors heterogeneous nuclear ribonuclear protein (HnRNP) H1, HnRNP D-like, HnRNP A2/B1 as well as heat shock protein 27 (Hsp27), glial fibrillary acidic protein and enolase 1 (ENO1). These glycoproteins were non-detectable in the non-metastatic breast cancer cell lines. The recognition of HnRNPs, Hsp27 and ENO1 by HPA correlated with O-GlcNAcylation of these proteins. Integrin α6 was the most abundant HPA glycoprotein in the breast cancer cells with a metastatic phenotype; this concurred with previous findings in colorectal cancer. This is the first report in which HPA has been shown to bind O-GlcNAcylated transcription factors. This class of proteins represents a new means by which HPA differentiates cancer cells with an aggressive metastatic phenotype.

78 citations

Journal ArticleDOI
TL;DR: Findings from a study commissioned by the UK Food Standards Agency suggest that a single format may encourage consumers to use front-of-pack labels in making healthy food choices and suggest that the existence of multiple formats in the marketplace may impede consumer comprehension and discourage use.
Abstract: Background: Nutrition labels are a potentially valuable tool to assist consumers in making healthy food choices. Front-of-pack labels are a relatively new format and are now widely used across many European countries, but it is unclear which of the many formats in use are best understood by consumers. It is also unclear whether the existence of multiple formats impedes understanding and use. This article addresses this question with findings from a study commissioned by the UK Food Standards Agency to provide evidence to inform policy decisions in this area. Methods: In-depth qualitative interviews were used to explore consumers’ decision-making processes when using two different front-of-pack label formats to judge the relative healthiness of a pair of products. Participants were presented with product pairs differently labelled and a series of structured prompts were used to access their internal dialogues and to identify any difficulties encountered. Results: The interviews revealed that making product comparisons using different label formats was challenging for participants and particularly for those product pairs where there was not an obvious answer. When the label formats on the product pairs lacked a common element, such as text, this also caused difficulties and misinterpretation. The comparisons also took time and effort that would be a deterrent in real-life situations. Conclusions: These findings indicate that the existence of multiple front-of-pack label formats in the marketplace may impede consumer comprehension and discourage use. They suggest that a single format may encourage consumers to use front-of-pack labels in making healthy food choices.

78 citations

Journal ArticleDOI
TL;DR: In this paper, the authors examine the ethical values underlying the way social tourism is defined and suggest a theoretical framework for the effects of social tourism, and discuss the definitions of "social tourism," distinguishing host-related and visitor-related forms, and clarify its potential value in combating social exclusion.
Abstract: Although social tourism has been seen in a number of countries as having potential to counter social exclusion, formulating a definition for the term is difficult. "Social tourism" is used to describe a variety of initiatives for a variety of different social groups. These range from holidays for children from low-income backgrounds, through improving accessibility in hotels, to offering ecological holidays. This article discusses the definitions of "social tourism," distinguishing host-related and visitor-related forms, and aims to clarify its potential value in combating social exclusion. It does so by examining the ethical values underlying the way social tourism is defined and suggesting a theoretical framework for the effects of social tourism. Some ethical views of society place an a priori moral duty on the stronger strata to support the weaker. Others do not judge the support of the weaker strata as an a priori dominant ethical principle, and judge the welfare of the state by the opportunity of all its strata. Ethical positions that see stronger strata as having a moral duty to support the weaker are more likely to be supportive toward both host-related and visitor-related social tourism. Those that do not will probably support host-related social tourism, but will support visitor-related social tourism, if publicly funded, only if it can demonstrate benefits for the whole of society. In Western liberal democracies where this is a prevailing view, visitor-related social tourism might justify public expenditure as a potential tool to combat social exclusion. It can be seen as a merit good if it improves excluded peoples' handicapping characteristics, through, for example, beneficial effects in health, self-esteem, and improvement of family relationships. However, there is little research to test its effectiveness in achieving these outcomes. Further research is required to evaluate whether social tourism can have a significant role in combating social exclusion, and thus justify support from public expenditure. Copyright © 2006 Cognizant Comm. Corp.

78 citations

Journal ArticleDOI
TL;DR: The Subjective Happiness Scale (SHS) has recently been developed as a more complete measure for the assessment of molar subjective happiness as mentioned in this paper, which has been translated and validated for German and Tagalog versions of the SHS and conduct an initial cross-cultural examination of subjective happiness.
Abstract: The Subjective Happiness Scale (SHS) has recently been developed as a more complete measure for the assessment of molar subjective happiness. In the present study, we report on the translation and validation of German and Tagalog versions of the SHS and conduct an initial cross-cultural examination of subjective happiness. In Study 1, 960 participants in Austria completed a German version of the SHS, which showed a unidimensional structure, good internal consistency, and good convergent validity with other measures of subjective well-being. In Study 2, 182 participants in the Philippines completed a Tagalog version of the scale, which likewise had a unidimensional structure, high internal consistency, and good convergent validity. Finally, the results of Study 3 indicate that there were significant cross-cultural differences in subjective happiness. Specifically, participants in individualist Austria and Britain had higher SHS scores than their counterparts in collectivist Malaysia and the Philippines. Limitations of these studies are discussed.

78 citations


Authors

Showing all 3028 results

NameH-indexPapersCitations
Barbara J. Sahakian14561269190
Peter B. Jones145185794641
Andrew Steptoe137100373431
Robert West112106153904
Aldo R. Boccaccini103123454155
Kevin Morgan9565549644
Shaogang Gong9243031444
Thomas A. Buchanan9134948865
Mauro Perretti9049728463
Jimmy D. Bell8858925983
Andrew D. McCulloch7535819319
Mark S. Goldberg7323518067
Dimitrios Buhalis7231623830
Ali Mobasheri6937014642
Michael E. Boulton6933123747
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202334
2022111
2021439
2020501
2019434
2018461