University of Westminster

About: University of Westminster is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Politics. The organization has 2944 authors who have published 8426 publications receiving 200236 citations. The organization is also known as: Westminster University & Royal Polytechnic Institution.

Fragmentation and Centralisation in the Governance of London: Influencing the Urban Policy and Planning Agenda:

Abstract: The government of London has fragmented. Numerous quangos have taken over urban policy and planning roles. Recently further bodies have arisen in response to the government's urban expenditure comp...

Perceptions of software quality: a pilot study

Abstract: Many software quality initiatives fail because they do not take account of the range of views that people have of quality. New approaches to software quality improvement will not work unless software developers believe in them, no matter how enthusiastic managers may be. This paper reports on a pilot study using the repertory grid technique that found evidence to support these assertions. The study findings justify further work and show that while the repertory grid technique is an appropriate instrument in this area it is resource intensive to apply and may not be practical in a wider study of a representative sample of the IT industry. The paper has practical recommendations for successful introduction of new software quality programmes. These recommendations stress the need for effective communication, leading to a shared understanding of ‘quality’, and for realistic goals that recognize the pressure of development schedules.

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Abstract: Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits. We report 14 alleles, including 7 newly characterized alleles, associated with higher adiposity but a favorable metabolic profile. Consistent with previous studies, individuals carrying more favorable adiposity alleles had higher body fat % and higher BMI but lower risk of type 2 diabetes, heart disease, and hypertension. These individuals also had higher subcutaneous fat but lower liver fat and a lower visceral-to-subcutaneous adipose tissue ratio. Individual alleles associated with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat but lower risk of type 2 diabetes. Most identified favorable adiposity alleles are associated with higher subcutaneous and lower liver fat, a mechanism consistent with the beneficial effects of storing excess triglycerides in metabolically low-risk depots.