University of Windsor

About: University of Windsor is a education organization based out in Windsor, Ontario, Canada. It is known for research contribution in the topics: Population & Argumentation theory. The organization has 10654 authors who have published 22307 publications receiving 435906 citations. The organization is also known as: UWindsor & Assumption University of Windsor.

Evaluating the utility of ICD-10 diagnostic criteria for postconcussion syndrome following mild traumatic brain injury

Abstract: The present study investigated the utility of the International Classification of Diseases and Related Health Problems, 10th edition (ICD-10) diagnostic criteria for postconcussion syndrome (PCS) symptoms by comparing symptom endorsement rates in a group of patients with mild traumatic brain injury (MTBI) to those of a noninjured control group at one month and three months post-injury. The 110 MTBI patients and 118 control participants were group-matched on age, gender, and education level. Seven of the nine self-reported ICD-10 PCS symptoms differentiated the groups at one month post-injury and two symptoms differentiated the groups at three months post-injury: symptom endorsement rates were higher in the MTBI group at both time periods. Fatiguing quickly and dizziness/vertigo best differentiated the groups at both time periods, while depression and anxiety/tension failed to differentiate the groups at either time period. Collectively, the ICD-10 PCS symptoms accurately classified the MTBI patients at one month post-injury, with the optimal positive test threshold of endorsement of five symptoms coinciding with a sensitivity and specificity of 73% and 61%, respectively. The ICD-10 PCS symptoms were unable to accurately classify the MTBI patients at three months post-injury.

Structure and sequence evolution of three legume chloroplast DNAs

Abstract: Chloroplast DNAs from soybean (Glycine max), common bean (Phaseolus vulgaris) and mung bean (Vigna radiata) have been compared in overall structure and nucleotide sequence homologies. Detailed restriction maps demonstrate that the soybean and common bean genomes possess the classical large chloroplast DNA inverted repeat, encoding ribosomal RNA genes, as found previously in mung bean (Palmer and Thompson 1981 a). Heterologous filter hybridizations indicate essentially complete colinearity between mung bean and common bean chloroplast DNAs. Although the linear order of sequence elements is also conserved between soybean and mung bean DNAs, two regions of deletions/additions, each totaling almost 5 kilobase pairs in size, have been identified at the ends of the large single copy DNA region. Alignment and comparison of restriction maps has allowed calculation of nucleotide sequence divergence values for the three DNAs. Mung bean and soybean chloroplast DNAs differ by an average of 10–13% in nucleotide sequence, while mung bean and common bean are significantly more closely related, differing by only 5–6% in base sequence. Base substitutions are distributed non-randomly in these chloroplast DNAs; chloroplast ribosomal DNA is relatively conserved and the two deletion/addition regions relatively diverged in base sequence.

Evidence for iNOS-dependent peroxynitrite production in diabetic platelets.

Abstract: Aims/hypothesis. The aim of the present study was twofold. Firstly, to determine whether diabetic platelets produce more peroxynitrite than normal platelets and secondly to correlate the peroxynitrite production with the intraplatelet induction of the inducible isoform of nitric oxide-synthase. Methods. Intraplatelet peroxynitrite production was monitored with dichlorofluorescin acetate with a combination of confocal microscopy and steady-state fluorescence. The platelets were probed for the induction of the inducible-nitric oxide-synthase by western immunoblotting. Results. In the presence of extracellular l-arginine (100 μmol/l), platelets from subjects with Type I (insulin-dependent) diabetes displayed about 5 times higher fluorescence than those from control subjects. To determine whether inducible-nitric oxide-synthase was the source of peroxynitrite, dichlorofluorescein production was quantified as a function of l-arginine as well as nitric oxide-synthase inhibitors, in platelets from control subjects, subjects with Type I diabetes and subjects with Type II (non-insulin-dependent) diabetes mellitus. Platelets from subjects with Type I yielded about sevenfold and those from Type II about threefold larger amounts of l-arginine/nitric oxide-synthase-dependent dichlorofluorescein fluorescence than those from control subjects. The platelets were then immunologically probed for inducible-nitric oxide-synthase, which has previously been implicated in peroxynitrite production and detected in megakaryocytes of subjects with coronary heart disease. Western immunoblots of intraplatelet proteins indicated that the inducible-nitric oxide-synthase was absent in control subjects. Platelets from both Type I and Type II diabetic subjects, however, contained inducible-nitric oxide-synthase. Conclusion/interpretation. Inducible-nitric oxide-synthase-derived peroxynitrite is a source of platelet damage in diabetes. [Diabetologia (1999) 42: 539–544]

Distinguishing individual vibrational fingerprints: single-molecule surface-enhanced resonance raman scattering from one-to-one binary mixtures in Langmuir-Blodgett monolayers.

Abstract: Here, it is demonstrated that similar chemical species within a multicomponent sample can be distinguished, down to the single-molecule level, by means of their surface-enhanced vibrational fingerprints. Surface-enhanced resonance Raman scattering spectra and 2D spatial intensity maps are recorded from thin Ag nanoparticle films coated with fatty acid Langmuir-Blodgett monolayers containing one-to-one binary mixtures, at varying concentrations, of two dye molecules of similar absorption and scattering cross section (n-pentyl-5-salicylimidoperylene and octadecylrhodamine B). The results reveal the change in the distribution of the two dyes within the monolayer, and the breakdown of ensemble spectral averaging, which occur as the single-molecule regime is approached. It is found that the unimolecular level is reached when 1-10 molecules of each dye occupy the 1-microm2 scattering areas probed by the laser. These signals are attributed to the rare spatial coincidence of isolated target analyte molecules and localized electromagnetic hot spots in the nanostructured metal film. The bianalyte nature of the samples provides strong corroborative support for the attribution of spectra to single molecules at high dilution, while the effect of domain formation/aggregation is found to be important at higher concentrations.

In Parents’ Voices: The Education of Children With Autism Spectrum Disorders

Abstract: Parents of 144 children with autism spectrum disorders were surveyed regarding their perceptions of and satisfaction with the education their children were receiving. This article focuses on an analysis of the parents’ responses to the open-ended questions of this survey. Overall themes that emerged repeatedly across all questions concerned the ability of school personnel to effectively manage children’s behavior, teacher education and understanding of the disability, and effective communication and collaboration between parents and school. The implications for future research and practice emerging from these findings are discussed.