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Institution

University of Wisconsin-Madison

EducationMadison, Wisconsin, United States
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.
Topics: Population, Poison control, Gene, Health care, Galaxy


Papers
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Journal ArticleDOI
TL;DR: The concepts are introduced, a framework in which the critical issues can be expressed and analyzed are provided, and it is pointed out how MPC allows practitioners to address the trade-offs that must be considered in implementing a control technology.
Abstract: The paper provides a reasonably accessible and self-contained tutorial exposition on model predictive control (MPC). It is aimed at readers with control expertise, particularly practitioners, who wish to broaden their perspective in the MPC area of control technology. We introduce the concepts, provide a framework in which the critical issues can be expressed and analyzed, and point out how MPC allows practitioners to address the trade-offs that must be considered in implementing a control technology.

1,073 citations

Journal ArticleDOI
TL;DR: In this paper, the authors consider four different approximations to the log-likelihood, comparing their computational and statistical properties, and conclude that the linear mixed-effects (LME) approximation suggested by Lindstrom and Bates, t
Abstract: Nonlinear mixed-effects models have received a great deal of attention in the statistical literature in recent years because of the flexibility they offer in handling the unbalanced repeated-measures data that arise in different areas of investigation, such as pharmacokinetics and economics. Several different methods for estimating the parameters in nonlinear mixed-effects model have been proposed. We concentrate here on two of them—maximum likelihood and restricted maximum likelihood. A rather complex numerical issue for (restricted) maximum likelihood estimation in nonlinear mixed-effects models is the evaluation of the log-likelihood function of the data, because it involves the evaluation of a multiple integral that, in most cases, does not have a closed-form expression. We consider here four different approximations to the log-likelihood, comparing their computational and statistical properties. We conclude that the linear mixed-effects (LME) approximation suggested by Lindstrom and Bates, t...

1,073 citations

Journal ArticleDOI
08 Sep 2006-Cell
TL;DR: It is shown that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR.

1,072 citations

Journal ArticleDOI
TL;DR: It is confirmed that the self-serving attributional bias is pervasive in the general population but demonstrates significant variability across age, culture, and psychopathology.
Abstract: Researchers have suggested the presence of a self-serving attributional bias, with people making more internal, stable, and global attributions for positive events than for negative events. This study examined the magnitude, ubiquity, and adaptiveness of this bias. The authors conducted a meta-analysis of 266 studies, yielding 503 independent effect sizes. The average d was 0.96, indicating a large bias. The bias was present in nearly all samples. There were significant age differences, with children and older adults displaying the largest biases. Asian samples displayed significantly smaller biases (d = 0.30) than U.S. (d = 1.05) or Western (d = 0.70) samples. Psychopathology was associated with a significantly attenuated bias (d = 0.48) compared with samples without psychopathology (d = 1.28) and community samples (d = 1.08). The bias was smallest for samples with depression (0.21), anxiety (0.46), and attention-deficit/hyperactivity disorder (0.55). Findings confirm that the self-serving attributional bias is pervasive in the general population but demonstrates significant variability across age, culture, and psychopathology.

1,071 citations

Journal ArticleDOI
01 May 2019-Nature
TL;DR: A comprehensive assessment of the world’s rivers and their connectivity shows that only 37 per cent of rivers longer than 1,000 kilometres remain free-flowing over their entire length.
Abstract: Free-flowing rivers (FFRs) support diverse, complex and dynamic ecosystems globally, providing important societal and economic services. Infrastructure development threatens the ecosystem processes, biodiversity and services that these rivers support. Here we assess the connectivity status of 12 million kilometres of rivers globally and identify those that remain free-flowing in their entire length. Only 37 per cent of rivers longer than 1,000 kilometres remain free-flowing over their entire length and 23 per cent flow uninterrupted to the ocean. Very long FFRs are largely restricted to remote regions of the Arctic and of the Amazon and Congo basins. In densely populated areas only few very long rivers remain free-flowing, such as the Irrawaddy and Salween. Dams and reservoirs and their up- and downstream propagation of fragmentation and flow regulation are the leading contributors to the loss of river connectivity. By applying a new method to quantify riverine connectivity and map FFRs, we provide a foundation for concerted global and national strategies to maintain or restore them. A comprehensive assessment of the world’s rivers and their connectivity shows that only 37 per cent of rivers longer than 1,000 kilometres remain free-flowing over their entire length.

1,071 citations


Authors

Showing all 109671 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Ronald C. Kessler2741332328983
Gordon H. Guyatt2311620228631
Yi Chen2174342293080
David Miller2032573204840
Robert M. Califf1961561167961
Ronald Klein1941305149140
Joan Massagué189408149951
Jens K. Nørskov184706146151
Terrie E. Moffitt182594150609
H. S. Chen1792401178529
Ramachandran S. Vasan1721100138108
Masayuki Yamamoto1711576123028
Avshalom Caspi170524113583
Jiawei Han1681233143427
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023333
20221,390
202110,148
20209,483
20199,278
20188,546