scispace - formally typeset
Search or ask a question
Institution

University of Wisconsin-Madison

EducationMadison, Wisconsin, United States
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.
Topics: Population, Poison control, Gene, Health care, Galaxy


Papers
More filters
Journal ArticleDOI
01 Jan 2013-Genetics
TL;DR: A bacterial CRISPR RNA/Cas9 system is adapted to precisely engineer the Drosophila genome and it is reported that Cas9-mediated genomic modifications are efficiently transmitted through the germline.
Abstract: We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila.

1,067 citations

Book ChapterDOI
TL;DR: The three-stage least squares (3-STMLEC) method as discussed by the authors is the first method that uses the moment matrix of the structural disturbances to estimate all coefficients of the entire system simultaneously.
Abstract: In simple though approximate terms, the two-stage least squares method of estimating a structural equation consists of two steps, the first of which serves to estimate the moment matrix of the reduced-form disturbances and the second to estimate the coefficients of one single structural equation after its jointly dependent variables are “purified” by means of the moment matrix just mentioned. The three-stage least squares method, which is developed in this paper, goes one step further by using the two-stage least squares estimated moment matrix of the structural disturbances to estimate all coefficients of the entire system simultaneously. The method has full-information characteristics to the extent that, if the moment matrix of the structural disturbances is not diagonal (that is, if the structural disturbances have nonzero “contemporaneous” covariances), the estimation of the coefficients of any identifiable equation gains in efficiency as soon as there are other equations that are over-identified. Further, the method can take account of restrictions on parameters in different structural equations. And it is very simple computationally, apart from the inversion of one big matrix.

1,067 citations

Journal ArticleDOI
26 Apr 2010
TL;DR: In this article, the authors formalize the notion of multipath sparsity and present a new approach to estimate sparse (or effectively sparse) multipath channels that is based on some of the recent advances in the theory of compressed sensing.
Abstract: High-rate data communication over a multipath wireless channel often requires that the channel response be known at the receiver. Training-based methods, which probe the channel in time, frequency, and space with known signals and reconstruct the channel response from the output signals, are most commonly used to accomplish this task. Traditional training-based channel estimation methods, typically comprising linear reconstruction techniques, are known to be optimal for rich multipath channels. However, physical arguments and growing experimental evidence suggest that many wireless channels encountered in practice tend to exhibit a sparse multipath structure that gets pronounced as the signal space dimension gets large (e.g., due to large bandwidth or large number of antennas). In this paper, we formalize the notion of multipath sparsity and present a new approach to estimating sparse (or effectively sparse) multipath channels that is based on some of the recent advances in the theory of compressed sensing. In particular, it is shown in the paper that the proposed approach, which is termed as compressed channel sensing (CCS), can potentially achieve a target reconstruction error using far less energy and, in many instances, latency and bandwidth than that dictated by the traditional least-squares-based training methods.

1,066 citations

Journal ArticleDOI
TL;DR: In this article, the authors show that advertising executional cues can influence communication effectiveness, and that communication effectiveness is in part driven by consumer behavior, which is similar to our findings.
Abstract: Considerable research suggests that advertising executional cues can influence communication effectiveness. Related research indicates that communication effectiveness is in part driven by consumer...

1,066 citations

Journal ArticleDOI
TL;DR: In patients with MCI, exercise training (6 months) is likely to improve cognitive measures and cognitive training may improve cognitive Measures, and no high-quality evidence exists to support pharmacologic treatments for MCI.
Abstract: Objective To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). Methods The guideline panel systematically reviewed MCI prevalence, prognosis, and treatment articles according to AAN evidence classification criteria, and based recommendations on evidence and modified Delphi consensus. Results MCI prevalence was 6.7% for ages 60–64, 8.4% for 65–69, 10.1% for 70–74, 14.8% for 75–79, and 25.2% for 80–84. Cumulative dementia incidence was 14.9% in individuals with MCI older than age 65 years followed for 2 years. No high-quality evidence exists to support pharmacologic treatments for MCI. In patients with MCI, exercise training (6 months) is likely to improve cognitive measures and cognitive training may improve cognitive measures. Major recommendations Clinicians should assess for MCI with validated tools in appropriate scenarios (Level B). Clinicians should evaluate patients with MCI for modifiable risk factors, assess for functional impairment, and assess for and treat behavioral/neuropsychiatric symptoms (Level B). Clinicians should monitor cognitive status of patients with MCI over time (Level B). Cognitively impairing medications should be discontinued where possible and behavioral symptoms treated (Level B). Clinicians may choose not to offer cholinesterase inhibitors (Level B); if offering, they must first discuss lack of evidence (Level A). Clinicians should recommend regular exercise (Level B). Clinicians may recommend cognitive training (Level C). Clinicians should discuss diagnosis, prognosis, long-term planning, and the lack of effective medicine options (Level B), and may discuss biomarker research with patients with MCI and families (Level C).

1,064 citations


Authors

Showing all 109671 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Ronald C. Kessler2741332328983
Gordon H. Guyatt2311620228631
Yi Chen2174342293080
David Miller2032573204840
Robert M. Califf1961561167961
Ronald Klein1941305149140
Joan Massagué189408149951
Jens K. Nørskov184706146151
Terrie E. Moffitt182594150609
H. S. Chen1792401178529
Ramachandran S. Vasan1721100138108
Masayuki Yamamoto1711576123028
Avshalom Caspi170524113583
Jiawei Han1681233143427
Network Information
Related Institutions (5)
University of Washington
305.5K papers, 17.7M citations

96% related

University of Pennsylvania
257.6K papers, 14.1M citations

96% related

University of California, San Diego
204.5K papers, 12.3M citations

95% related

University of Michigan
342.3K papers, 17.6M citations

95% related

Stanford University
320.3K papers, 21.8M citations

95% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023333
20221,390
202110,148
20209,483
20199,278
20188,546