Institution
University of Wisconsin-Madison
Education•Madison, Wisconsin, United States•
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.
Topics: Population, Poison control, Gene, Health care, Galaxy
Papers published on a yearly basis
Papers
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TL;DR: Protecting children against the effects of socioeconomic adversity could reduce the burden of disease experienced by adults, and upward mobility did not mitigate or reverse the adverse effects of low childhood socioeconomic status on adult health.
987 citations
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TL;DR: The in vitro differentiation of human ES cells provides an opportunity to better understand human hematopoiesis and could lead to a novel source of cells for transfusion and transplantation therapies.
Abstract: Human embryonic stem (ES) cells are undifferentiated, pluripotent cells that can be maintained indefinitely in culture. Here we demonstrate that human ES cells differentiate to hematopoietic precursor cells when cocultured with the murine bone marrow cell line S17 or the yolk sac endothelial cell line C166. This hematopoietic differentiation requires fetal bovine serum, but no other exogenous cytokines. ES cell-derived hematopoietic precursor cells express the cell surface antigen CD34 and the hematopoietic transcription factors TAL-1, LMO-2, and GATA-2. When cultured on semisolid media with hematopoietic growth factors, these hematopoietic precursor cells form characteristic myeloid, erythroid, and megakaryocyte colonies. Selection for CD34+ cells derived from human ES cells enriches for hematopoietic colony-forming cells, similar to CD34 selection of primary hematopoietic tissue (bone marrow, umbilical cord blood). More terminally differentiated hematopoietic cells derived from human ES cells under these conditions also express normal surface antigens: glycophorin A on erythroid cells, CD15 on myeloid cells, and CD41 on megakaryocytes. The in vitro differentiation of human ES cells provides an opportunity to better understand human hematopoiesis and could lead to a novel source of cells for transfusion and transplantation therapies.
986 citations
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TL;DR: The first empirical test of whether behavioral differences among children in the first 3 years of life are linked to specific adult psychiatric disorders: anxiety and mood disorders, antisocial personality disorder, recidivistic and violent crime, alcoholism, and suicidal behavior was provided by.
Abstract: Background: This study provides, to our knowledge, the first empirical test of whether behavioral differences among children in the first 3 years of life are linked to specific adult psychiatric disorders: anxiety and mood disorders, antisocial personality disorder, recidivistic and violent crime, alcoholism, and suicidal behavior. Methods: In a longitudinal-epidemiological study, 3-year-old children were classified into groups based on examiner observations of their behavior. At age 21 years, they were reassessed for psychopathologic functioning using standardized interviews based on DSM-IIJ-R criteria. Results: Although effect sizes were small,undercontrolled(includes children who are impulsive, restless, and distractible) andinhibited(includes children who are shy, fearful, and easily upset) children differed significantly from comparison children in young adulthood. Undercontrolled 3-year-olds were more likely at 21 years to meet diagnostic criteria for antisocial personality disorder and to be involved in crime. Inhibited 3-year-olds were more likely at 21 years to meet diagnostic criteria for depression. Both groups were more likely to attempt suicide, and boys in both groups had alcohol-related problems. Controls for family social class did not change the findings. Conclusions: Some forms of adult psychopathologic abnormality are meaningfully linked, albeit weakly, to behavioral differences observed among children in the third year of life.
986 citations
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National Institutes of Health1, University of Washington2, Centers for Disease Control and Prevention3, University of Massachusetts Medical School4, University of Wisconsin-Madison5, Brown University6, Harvard University7, University of Texas Southwestern Medical Center8, Sharp Memorial Hospital9, Columbia University10, University of Minnesota11, University of North Carolina at Chapel Hill12, Boston Children's Hospital13
TL;DR: The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters, and maximal sterile barrier precautions during central venous catheter insertion, which can reduce the risk for serious catheter-related infection.
Abstract: Background:Although many catheter-related blood-stream infections (CRBSIs) are preventable, measures to reduce these infections are not uniformly implementedObjective:To update an existing evidenced-based guideline that promotes strategies to prevent CRBSIsData Sources:The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articlesStudies Included:Laboratory-based studies, controlled clinical trials, prospective interventional trials, and epidemiologic investigationsOutcome Measures:Reduction in CRBSI, catheter colonization, or catheter-related infectionSynthesis:The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters; maximal sterile barrier precautions during central venous catheter insertion; use of a 2% chlorhexidine preparation for skin antisepsis; no routine replacement of central venous catheters for prevention of infection; and use of antiseptic/antibiotic-impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (ie, education and training, maximal sterile barrier precautions, and 2% chlorhexidine for skin antisepsis)Conclusion:Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection
985 citations
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TL;DR: The authors summarized the evidence related to three different interpretations of the data on college and school impact on the socialization of teachers, and discussed the implications of these interpretations for practice in teacher education and for research on the processes of occupational socialization.
Abstract: or college is absolved from any responsibility in the development of the traditional perspectives that eventually emerge, and the major source of socialization influence is the schools (Fuller & Bown, 1975). Given the highly consistent results of numerous longitudinal and cross-sectional studies of education students and teachers at various points in their professional careers, this view seems highly plausible. However, a number of investigators both in the United States and the United Kingdom have recently begun to raise many questions about it. This paper will summarize the evidence related to three different interpretations of the data on college and school impact on the socialization of teachers, and will discuss the implications of these interpretations for practice in teacher education and for research on the processes of occupational socialization.
985 citations
Authors
Showing all 109671 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric S. Lander | 301 | 826 | 525976 |
Ronald C. Kessler | 274 | 1332 | 328983 |
Gordon H. Guyatt | 231 | 1620 | 228631 |
Yi Chen | 217 | 4342 | 293080 |
David Miller | 203 | 2573 | 204840 |
Robert M. Califf | 196 | 1561 | 167961 |
Ronald Klein | 194 | 1305 | 149140 |
Joan Massagué | 189 | 408 | 149951 |
Jens K. Nørskov | 184 | 706 | 146151 |
Terrie E. Moffitt | 182 | 594 | 150609 |
H. S. Chen | 179 | 2401 | 178529 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Avshalom Caspi | 170 | 524 | 113583 |
Jiawei Han | 168 | 1233 | 143427 |