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Showing papers by "University of Wisconsin–Milwaukee published in 2006"


Journal ArticleDOI
TL;DR: Nanowires produced by the oxygenic phototrophic cyanobacterium Synechocystis PCC6803 and the thermophilic, fermentative bacterium Pelotomaculum thermopropionicum reveal that electrically conductive appendages are not exclusive to dissimilatory metal-reducing bacteria and may, in fact, represent a common bacterial strategy for efficient electron transfer and energy distribution.
Abstract: Shewanella oneidensis MR-1 produced electrically conductive pilus-like appendages called bacterial nanowires in direct response to electron-acceptor limitation. Mutants deficient in genes for c-type decaheme cytochromes MtrC and OmcA, and those that lacked a functional Type II secretion pathway displayed nanowires that were poorly conductive. These mutants were also deficient in their ability to reduce hydrous ferric oxide and in their ability to generate current in a microbial fuel cell. Nanowires produced by the oxygenic phototrophic cyanobacterium Synechocystis PCC6803 and the thermophilic, fermentative bacterium Pelotomaculum thermopropionicum reveal that electrically conductive appendages are not exclusive to dissimilatory metal-reducing bacteria and may, in fact, represent a common bacterial strategy for efficient electron transfer and energy distribution.

1,666 citations


Journal ArticleDOI
03 May 2006-JAMA
TL;DR: Patients receiving medical management with naltrexone, CBI, or both fared better on drinking outcomes, whereas acamprosate showed no evidence of efficacy, with or without CBI.
Abstract: ContextAlcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings.ObjectivesTo evaluate the efficacy of medication, behavioral therapies, and their combinations for treatment of alcohol dependence and to evaluate placebo effect on overall outcome.Design, Setting, and ParticipantsRandomized controlled trial conducted January 2001-January 2004 among 1383 recently alcohol-abstinent volunteers (median age, 44 years) from 11 US academic sites with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnoses of primary alcohol dependence.InterventionsEight groups of patients received medical management with 16 weeks of naltrexone (100 mg/d) or acamprosate (3 g/d), both, and/or both placebos, with or without a combined behavioral intervention (CBI). A ninth group received CBI only (no pills). Patients were also evaluated for up to 1 year after treatment.Main Outcome MeasuresPercent days abstinent from alcohol and time to first heavy drinking day.ResultsAll groups showed substantial reduction in drinking. During treatment, patients receiving naltrexone plus medical management (n = 302), CBI plus medical management and placebos (n = 305), or both naltrexone and CBI plus medical management (n = 309) had higher percent days abstinent (80.6, 79.2, and 77.1, respectively) than the 75.1 in those receiving placebos and medical management only (n = 305), a significant naltrexone × behavioral intervention interaction (P = .009). Naltrexone also reduced risk of a heavy drinking day (hazard ratio, 0.72; 97.5% CI, 0.53-0.98; P = .02) over time, most evident in those receiving medical management but not CBI. Acamprosate showed no significant effect on drinking vs placebo, either by itself or with any combination of naltrexone, CBI, or both. During treatment, those receiving CBI without pills or medical management (n = 157) had lower percent days abstinent (66.6) than those receiving placebo plus medical management alone (n = 153) or placebo plus medical management and CBI (n = 156) (73.8 and 79.8, respectively; P<.001). One year after treatment, these between-group effects were similar but no longer significant.ConclusionsPatients receiving medical management with naltrexone, CBI, or both fared better on drinking outcomes, whereas acamprosate showed no evidence of efficacy, with or without CBI. No combination produced better efficacy than naltrexone or CBI alone in the presence of medical management. Placebo pills and meeting with a health care professional had a positive effect above that of CBI during treatment. Naltrexone with medical management could be delivered in health care settings, thus serving alcohol-dependent patients who might otherwise not receive treatment.Trial Registrationclinicaltrials.gov Identifier: NCT00006206

1,584 citations


Journal ArticleDOI
TL;DR: In this paper, the authors used Deci, Spiegel, Ryan, Koestner, & Kauffman's (1982) teacher-student laboratory paradigm to randomly assign 72 pairs of same-sex preservice teachers into the role of either teacher or student.
Abstract: Teachers with an autonomy-supportive style rely on different instructional behaviors to motivate their students than do teachers with a controlling style. In the present investigation, the authors tested which of these instructional behaviors actually correlated positively or negatively with students' autonomy. The authors used Deci, Spiegel, Ryan, Koestner, & Kauffman's (1982) teacher-student laboratory paradigm to randomly assign 72 pairs of same-sex preservice teachers into the role of either teacher or student. From videotapes of the 10-min instructional episode, raters scored 11 hypothesized autonomy-supportive behaviors and 10 hypothesized controlling behaviors. Correlational analyses confirmed that students perceived the functional significance of 8 instructional behaviors as autonomy supports and 6 instructional behaviors as autonomy thwarts. The discussion focuses on the interpretation and classroom implications of these data.

1,221 citations


Journal ArticleDOI
TL;DR: It is argued that individuals espouse national cultural values to differing degrees and that social norms are stronger determinants of intended behavior for individuals who espouse feminine and high uncertainty avoidance cultural values.
Abstract: Prior research has examined age, gender, experience, and voluntariness as the main moderators of beliefs on technology acceptance. This paper extends this line of research beyond these demographic and situational variables. Motivated by research that suggests that behavioral models do not universally hold across cultures, the paper identifies espoused national cultural values as an important set of individual difference moderators in technology acceptance. Building on research in psychological anthropology and cultural psychology that assesses cultural traits by personality tests at the individual level of analysis, we argue that individuals espouse national cultural values to differing degrees. These espoused national cultural values of masculinity/femininity, individualism/collectivism, power distance, and uncertainty avoidance are incorporated into an extended model of technology acceptance as moderators. We conducted two studies to test our model. Results indicated that, as hypothesized, social norms are stronger determinants of intended behavior for individuals who espouse feminine and high uncertainty avoidance cultural values. Contrary to expectations, espoused masculinity/femininity values did not moderate the relationship between perceived usefulness and behavioral intention but, as expected, did moderate the relationship between perceived ease of use and behavioral intention.

1,010 citations


Journal ArticleDOI
TL;DR: In this paper, a suite of modeled and derived measures (produced from daily maximum-minimum temperatures) linking plant development (phenology) with its basic climatic drivers provide a reliable and spatially extensive method for monitoring general impacts of global warming on the start of the growing season.
Abstract: Recent warming of Northern Hemisphere (NH) land is well documented and typically greater in winter/spring than other seasons. Physical environment responses to warming have been reported, but not details of large-area temperate growing season impacts, or consequences for ecosystems and agriculture. To date, hemispheric-scale measurements of biospheric changes have been confined to remote sensing. However, these studies did not provide detailed data needed for many investigations. Here, we show that a suite of modeled and derived measures (produced from daily maximum–minimum temperatures) linking plant development (phenology) with its basic climatic drivers provide a reliable and spatially extensive method for monitoring general impacts of global warming on the start of the growing season. Results are consistent with prior smaller area studies, confirming a nearly universal quicker onset of early spring warmth (spring indices (SI) first leaf date, −1.2 days decade−1), late spring warmth (SI first bloom date, −1.0 days decade−1; last spring day below 5°C, −1.4 days decade−1), and last spring freeze date (−1.5 days decade−1) across most temperate NH land regions over the 1955–2002 period. However, dynamics differ among major continental areas with North American first leaf and last freeze date changes displaying a complex spatial relationship. Europe presents a spatial pattern of change, with western continental areas showing last freeze dates getting earlier faster, some central areas having last freeze and first leaf dates progressing at about the same pace, while in portions of Northern and Eastern Europe first leaf dates are getting earlier faster than last freeze dates. Across East Asia last freeze dates are getting earlier faster than first leaf dates.

899 citations


Journal ArticleDOI
Abstract: In this note we make a minor correction to a scheme for robots to broadcast their private information. All major results of the paper [I. Suzuki and M. Yamashita, SIAM J. Comput., 28 (1999), pp. 1347-1363] hold with this correction.

667 citations


Journal ArticleDOI
TL;DR: The main objective was to assess the potential impact that nanoparticles may have on release into aquatic environments and to identify the most appropriate nanotechnology to preserve the aquatic environment while advancing medical and environmental technology.
Abstract: Nanoparticles (1-100 nm) comprise the latest technological advances designed to do everything from absorb environmental toxins to deliver drugs to a target organ. Recently, however, they have come under scrutiny for the potential to cause environmental damage. Because compounds in this miniature size range have chemical properties that differ from those of their larger counterparts, nanoparticles deserve special attention. Our main objective was to assess the potential impact that nanoparticles may have on release into aquatic environments. We prepared titanium dioxide (TiO2) and fullerene (C60) nanoparticles by filtration in tetrahydrofuran or by sonication. Daphnia magna were exposed to the four solutions using U.S. Environmental Protection Agency 48-h acute toxicity tests. Images of the particle solutions were recorded using transmission-electron microscopy, and the median lethal concentration, lowest-observable-effect concentration, and no-observable-effect concentration were determined. Exposure to filtered C60 and filtered TiO2 caused an increase in mortality with an increase in concentration, whereas fullerenes show higher levels of toxicity at lower concentrations. Exposure to the sonicated solutions caused varied mortality. Understanding the potential impacts of nanoparticles will help to identify the most appropriate nanotechnology to preserve the aquatic environment while advancing medical and environmental technology.

633 citations


Journal ArticleDOI
TL;DR: In this article, the role of urban political economy, private-public property relations, and race and ethnicity in the social production of Milwaukee's urban forest was investigated by integrating urban-forest canopy-cover data from aerial photography, United States Census data, and qualitative data collected through in-depth interviews.
Abstract: This article investigates the role of urban political economy, private-public property relations, and race and ethnicity in the social production of Milwaukee's urban forest. By integrating urban-forest canopy-cover data from aerial photography, United States Census data, and qualitative data collected through in-depth interviews, this analysis suggests that there is an inequitable distribution of urban canopy cover within Milwaukee. Since urban trees positively affect quality of life, the spatially inequitable distribution of urban trees in relation to race and ethnicity is yet another instance of urban environmental inequality that deserves greater consideration in light of contemporary and dynamic property relations within capitalist societies.

630 citations


Journal ArticleDOI
TL;DR: Exposure to prenatal tobacco and environmental lead are risk factors for ADHD in U.S. children, and if causally linked, these data suggest that prenatal tobacco exposure accounts for 270,000 excess cases of ADHD, and lead Exposure accounts for 290,000 extra cases of ADD.
Abstract: Objective The purpose of this study was to examine the association of exposures to tobacco smoke and environmental lead with attention deficit hyperactivity disorder (ADHD). Methods Data were obtained from the National Health and Nutrition Examination Survey 1999-2002. Prenatal and postnatal tobacco exposure was based on parent report; lead exposure was measured using blood lead concentration. ADHD was defined as having current stimulant medication use and parent report of ADHD diagnosed by a doctor or health professional. Results Of 4,704 children 4-15 years of age, 4.2% were reported to have ADHD and stimulant medication use, equivalent to 1.8 million children in the United States. In multivariable analysis, prenatal tobacco exposure [odds ratio (OR) = 2.5; 95% confidence interval (CI), 1.2-5.2] and higher blood lead concentration (first vs. fifth quintile, OR = 4.1; 95% CI, 1.2-14.0) were significantly associated with ADHD. Postnatal tobacco smoke exposure was not associated with ADHD (OR = 0.6; 95% CI, 0.3-1.3; p = 0.22). If causally linked, these data suggest that prenatal tobacco exposure accounts for 270,000 excess cases of ADHD, and lead exposure accounts for 290,000 excess cases of ADHD in U.S. children. Conclusions We conclude that exposure to prenatal tobacco and environmental lead are risk factors for ADHD in U.S. children.

555 citations


Journal ArticleDOI
TL;DR: Effects of B cell depletion by rituximab, a monoclonal antibody to CD20, were studied in patients with relapsing MS that had not responded optimally to standard immunomodulatory therapies.

419 citations


Journal ArticleDOI
TL;DR: The much lower prevalence of type 2 diabetes and obesity in the Pima Indians in Mexico than in the U.S. indicates that even in populations genetically prone to these conditions, their development is determined mostly by environmental circumstances, thereby suggesting that type 1 diabetes is largely preventable.
Abstract: OBJECTIVE — Type 2 diabetes and obesity have genetic and environmental determinants. We studied the effects of different environments on these diseases in Pima Indians in Mexico and the U.S. RESEARCH DESIGN AND METHODS — Adult Pima-Indian and non-Pima populations in the Sierra Madre mountains of Mexico were examined using oral glucose tolerance tests and assessments for obesity, physical activity, and other risk factors. Results were compared with those from Pima Indians in Arizona. Both Pima populations were typed for DNA polymorphisms to establish their genetic similarity. RESULTS — The age- and sex-adjusted prevalence of type 2 diabetes in the Mexican Pima Indians (6.9%) was less than one-fifth that in the U.S. Pima Indians (38%) and similar to that of non-Pima Mexicans (2.6%). The prevalence of obesity was similar in the Mexican Pima Indians (7% in men and 20% in women) and non-Pima Mexicans (9% in men and 27% in women) but was much lower than in the U.S. Pima Indians. Levels of physical activity were much higher in both Mexican groups than in the U.S. Pima Indians. The two Pima groups share considerable genetic similarity relative to other Native Americans. CONCLUSIONS — The much lower prevalence of type 2 diabetes and obesity in the Pima Indians in Mexico than in the U.S. indicates that even in populations genetically prone to these conditions, their development is determined mostly by environmental circumstances, thereby suggesting that type 2 diabetes is largely preventable. This study provides compelling evidence that changes in lifestyle associated with Westernization play a major role in the global epidemic of type 2 diabetes.

Journal ArticleDOI
TL;DR: The results indicate that there may be systematic differences in the outcomes associated with BPT and CBT when the setting of the intervention is considered, suggesting the need to carefully consider the effect of setting in future research.
Abstract: Extended the findings from previous meta-analytic work by comparing the effectiveness of behavioral parent-training (BPT) and cognitive-behavioral therapy (CBT) for youth with antisocial behavior problems. Youth demographic variables were also examined as potential moderators of the effectiveness of these 2 types of interventions. Thirty BPT studies and 41 CBT studies met inclusion criteria for this meta-analysis. The weighted mean effect size (ES) for all interventions was 0.40. Youth age was found to moderate the outcome of the 2 interventions, with BPT having a stronger effect for preschool and school-aged youth and CBT having a stronger effect for adolescents. The results also indicate that there may be systematic differences in the outcomes associated with BPT and CBT when the setting of the intervention is considered, suggesting the need to carefully consider the effect of setting in future research. This study also highlights the need for outcome research dealing with more diverse populations and the better classification of research participants on different developmental trajectories of antisocial behavior.

Journal ArticleDOI
Seiji Kawamura1, Masaki Ando2, Takashi Nakamura3, K. Tsubono2, Takahiro Tanaka3, I. Funaki, Naoki Seto1, Kenji Numata4, Shuichi Sato1, Kunihito Ioka, Nobuyuki Kanda5, T. Takashima, Kazuhiro Agatsuma2, Tomotada Akutsu2, Koh-suke Aoyanagi6, Koji Arai1, Y. Arase2, Akito Araya2, Hideki Asada7, Yoichi Aso8, Takeshi Chiba9, Toshikazu Ebisuzaki, Motohiro Enoki10, Yoshiharu Eriguchi2, Masa-Katsu Fujimoto1, Ryuichi Fujita11, Mitsuhiro Fukushima1, Toshifumi Futamase12, Katsuhiko Ganzu3, Tomohiro Harada13, Tatsuaki Hashimoto, Kazuhiro Hayama14, Wataru Hikida11, Yoshiaki Himemoto15, Hisashi Hirabayashi16, Takashi Hiramatsu2, Feng-Lei Hong17, Hideyuki Horisawa18, Mizuhiko Hosokawa19, Kiyotomo Ichiki2, Takeshi Ikegami17, Kaiki Taro Inoue20, Koji Ishidoshiro2, Hideki Ishihara5, Takehiko Ishikawa, Hideharu Ishizaki1, Hiroyuki Ito19, Yousuke Itoh21, S. Kamagasako2, Nobuki Kawashima20, Fumiko Kawazoe22, Hiroyuki Kirihara2, Naoko Kishimoto, Kenta Kiuchi6, Shiho Kobayashi23, Kazunori Kohri24, Hiroyuki Koizumi2, Yasufumi Kojima25, Keiko Kokeyama22, Wataru Kokuyama2, Kei Kotake1, Yoshihide Kozai, Hideaki Kudoh2, Hiroo Kunimori19, H. Kuninaka, Kazuaki Kuroda2, Keiichi Maeda6, Hideo Matsuhara, Yasushi Mino26, Osamu Miyakawa26, Shinji Miyoki2, Mutsuko Y. Morimoto, T. Morioka2, Toshiyuki Morisawa3, Shigenori Moriwaki2, Shinji Mukohyama2, Mitsuru Musha27, Shigeo Nagano19, Isao Naito, N. Nakagawa2, Kouji Nakamura1, Hiroyuki Nakano28, Ken-ichi Nakao5, Shinichi Nakasuka2, Yoshinori Nakayama29, E. Nishida22, Kazutaka Nishiyama, Atsushi J. Nishizawa3, Yoshito Niwa3, Masatake Ohashi2, Naoko Ohishi1, Masashi Ohkawa30, Akira Okutomi2, Kouji Onozato2, K. Oohara30, Norichika Sago31, Motoyuki Saijo31, Masa-aki Sakagami3, Shin-ichiro Sakai, Shihori Sakata22, Misao Sasaki3, Takashi Sato30, Masaru Shibata2, Hisa-aki Shinkai32, Kentaro Somiya33, Hajime Sotani34, Naoshi Sugiyama35, Yudai Suwa2, Hideyuki Tagoshi11, Kakeru Takahashi2, Tadayuki Takahashi, Hirotaka Takahashi36, Ryuichi Takahashi35, Akiteru Takamori2, Tetsushi Takano, Keisuke Taniguchi37, Atsushi Taruya2, Hiroyuki Tashiro3, M. Tokuda5, Masao Tokunari2, Morio Toyoshima19, Shinji Tsujikawa, Yoshiki Tsunesada38, Ken-ichi Ueda27, Masayoshi Utashima16, Hiroshi Yamakawa3, Kazuhiro Yamamoto1, Toshitaka Yamazaki1, Jun'ichi Yokoyama2, Chul-Moon Yoo3, Shijun Yoshida12, Taizoh Yoshino 
TL;DR: DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) as discussed by the authors is the future Japanese space gravitational wave antenna, which aims at detecting various kinds of gravitational waves between 1 mHz and 100 Hz frequently enough to open a new window of observation for gravitational wave astronomy.
Abstract: DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. It aims at detecting various kinds of gravitational waves between 1 mHz and 100 Hz frequently enough to open a new window of observation for gravitational wave astronomy. The pre-conceptual design of DECIGO consists of three drag-free satellites, 1000 km apart from each other, whose relative displacements are measured by a Fabry–Perot Michelson interferometer. We plan to launch DECIGO in 2024 after a long and intense development phase, including two pathfinder missions for verification of required technologies.

Journal ArticleDOI
TL;DR: The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo, and represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction.
Abstract: This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various in vitro and in vivo models. Low-intensity light therapy, commonly referred to as "photobiomodulation," uses light in the far-red to near-infrared region of the spectrum (630-1000 nm) and modulates numerous cellular functions. Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light. These studies were performed to determine the effect of NIR-LED light treatment on physiologic and pathologic processes. NIRLED light treatment stimulates the photoacceptor cytochrome c oxidase, resulting in increased energy metabolism and production. NIR-LED light treatment accelerates wound healing in ischemic rat and murine diabetic wound healing models, attenuates the retinotoxic effects of methanol-derived formic acid in rat models, and attenuates the developmental toxicity of dioxin in chicken embryos. Furthermore, NIR-LED light treatment prevents the development of oral mucositis in pediatric bone marrow transplant patients. The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo. NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction.

Journal ArticleDOI
TL;DR: It is shown that c-type cytochromes of a dissimilatory metal-reducing bacterium, Shewanella oneidensis MR-1, are essential for the reduction of U(VI) and formation of extracelluar UO 2 nanoparticles and this is the first study to the authors' knowledge to directly localize the OM-associated cyto Chromes with EPS, which contains biogenic UO2 nanoparticles.
Abstract: Modern approaches for bioremediation of radionuclide contaminated environments are based on the ability of microorganisms to effectively catalyze changes in the oxidation states of metals that in turn influence their solubility. Although microbial metal reduction has been identified as an effective means for immobilizing highly-soluble uranium(VI) complexes in situ, the biomolecular mechanisms of U(VI) reduction are not well understood. Here, we show that c-type cytochromes of a dissimilatory metal-reducing bacterium, Shewanella oneidensis MR-1, are essential for the reduction of U(VI) and formation of extracelluar UO 2 nanoparticles. In particular, the outer membrane (OM) decaheme cytochrome MtrC (metal reduction), previously implicated in Mn(IV) and Fe(III) reduction, directly transferred electrons to U(VI). Additionally, deletions of mtrC and/or omcA significantly affected the in vivo U(VI) reduction rate relative to wild-type MR-1. Similar to the wild-type, the mutants accumulated UO 2 nanoparticles extracellularly to high densities in association with an extracellular polymeric substance (EPS). In wild-type cells, this UO 2-EPS matrix exhibited glycocalyx-like properties and contained multiple elements of the OM, polysaccharide, and heme-containing proteins. Using a novel combination of methods including synchrotron-based X-ray fluorescence microscopy and high-resolution immune-electron microscopy, we demonstrate a close association of the extracellular UO 2 nanoparticles with MtrC and OmcA (outer membrane cytochrome). This is the first study to our knowledge to directly localize the OM-associated cytochromes with EPS, which contains biogenic UO 2 nanoparticles. In the environment, such association of UO 2 nanoparticles with biopolymers may exert a strong influence on subsequent behavior including susceptibility to oxidation by O 2 or transport in soils and sediments.

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TL;DR: Results demonstrated a significant reduction in hair pulling severity, impairment ratings, and hairs pulled, along with significant reductions in experiential avoidance and both anxiety and depressive symptoms in the ACT/HRT group compared to the waitlist control, implying that targeting experientsial avoidance may be useful in the treatment of TTM.

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TL;DR: It is proposed that broken inversion symmetry and the accompanying antisymmetric spin-orbit coupling, which admix spin-singlet and spin-triplet pairing, are responsible for this behavior of noncentrosymmetric superconductors Li2Pd3B andLi2Pt3B.
Abstract: We investigate the order parameter of noncentrosymmetric superconductors Li2Pd3B and Li2Pt3B via the behavior of the penetration depth lambda(T). The low-temperature penetration depth shows BCS-like behavior in Li2Pd3B, while in Li2Pt3B it follows a linear temperature dependence. We propose that broken inversion symmetry and the accompanying antisymmetric spin-orbit coupling, which admix spin-singlet and spin-triplet pairing, are responsible for this behavior. The triplet contribution is weak in Li2Pd3B, leading to a wholly open but anisotropic gap. The significantly larger spin-orbit coupling in Li2Pt3B allows the spin-triplet component to be larger in Li2Pt3B, producing line nodes in the energy gap as evidenced by the linear temperature dependence of lambda(T). The experimental data are in quantitative agreement with theory.

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TL;DR: It is found that the direct channel has a negative impact on the retailer’s performance, and, under some conditions, the manufacturer and the whole supply chain are better off.

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TL;DR: The results suggest that the climate system exhibits aspects of small-world networks as well as scale-free networks, with supernodes corresponding to major teleconnection patterns, and preliminary work suggests that temporal changes in the network's architecture may be used to identify signatures of global change.
Abstract: The study of networks has recently exploded into a major research tool in many areas of science. The discovery of “small world” and scale-free networks has led to many new insights about the collective behavior of a large number of interacting agents and complex systems. Here we introduce the basic ideas behind networks, as well as some initial applications of networks to the climate system. Our results suggest that the climate system exhibits aspects of small-world networks as well as scale-free networks, with supernodes corresponding to major teleconnection patterns. This result suggests that the organization of teleconnections may play a role in the stability of the climate system. In addition, preliminary work suggests that temporal changes in the network's architecture may be used to identify signatures of global change. These and other applications suggest that networks provide a new tool for investigating and reconstructing climate dynamics from both models and observations.

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TL;DR: This article reviewed and integrated literature on organizational impression management, recruitment, marketing, and social psychology and provided a framework to assist practitioners in attracting minority and female job applicants, and several avenues for future research are discussed.
Abstract: On account of a number of factors, many companies have increased recruitment targeting female and ethnic or racial minority job applicants. Despite evidence suggesting that these applicants are attracted by different factors than traditional applicants and an abundance of recruitment tactics suggested in the popular press, no empirically based approach to recruiting these populations has emerged. This article reviews and integrates literature on organizational impression management, recruitment, marketing, and social psychology and provides a framework to assist practitioners in attracting minority and female job applicants. In addition, several avenues for future research are discussed.

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TL;DR: The prevalence of a range of DSM‐IV psychiatric disorders in a sample of 119 4–16‐year‐old children with Williams syndrome was assessed using a structured diagnostic interview with their parents, finding a significant shift in Predominant Type of ADHD as a function of CA.
Abstract: The prevalence of a range of DSM-IV psychiatric disorders in a sample of 119 4-16-year-old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM-IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4-6 years) to Inattentive for the oldest group (ages 11-16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS.

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TL;DR: This study underscores the clinical significance of severe hair pulling and highlights the need for research on its pathogenesis and treatment.
Abstract: Background Trichotillomania (TTM) occurs in 0.6% to 3.4% of adults. Questions remain about phenomenological features of the disorder, its impact on functioning, and treatment utilization. The current study (i.e., The Trichotillomania Impact Project) was designed to provide initial information regarding these issues. Method An Internet-based survey was completed by 1697 individuals who self-reported symptoms consistent with a diagnosis of TTM (DSM-IV-TR). The survey assessed phenomenological experiences; social, occupational, academic, and psychological impact; as well as treatment-seeking experiences. The survey link operated from April 2005 through May 2005. Results Survey results suggest considerable variability in TTM phenomenology. Individuals with more severe TTM symptoms endorsed more frequent phenomenological experiences of physical or mental anxiety prior to pulling and relief, pleasure, or gratification after pulling. Mild to moderate life impairment in social, occupational, academic, and psychological functioning was reported for the entire study sample. These impairments were more pronounced as TTM symptoms became more severe. A summary of treatment seeking in the sample suggests that pharmacotherapy was the most commonly received treatment, followed by behavior therapy. Unfortunately, treatment in general was perceived as relatively ineffective. Conclusion This study underscores the clinical significance of severe hair pulling and highlights the need for research on its pathogenesis and treatment.

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TL;DR: In this article, hollow fly ash particles (cenospheres) were pressure infiltrated with A356 alloy melt to fabricate metal-matrix syntactic foam, using applied pressure up to 275kPa.
Abstract: Loose beds of hollow fly ash particles (cenospheres) were pressure infiltrated with A356 alloy melt to fabricate metal-matrix syntactic foam, using applied pressure up to 275 kPa. The volume fractions of cenospheres in the composites were in the range of 20–65%. The processing variables included melt temperature, gas pressure and particles size of fly ash. The effect of these processing variables on the microstructure and compressive properties of the synthesized composites is characterized. Compressive tests performed on these metal-matrix composites containing different volume fractions of hollow fly ash particles showed that their yield stress, Young's modulus, and plateau stress increase with an increase in the density. Variations in the compressive properties of the composites in the present study were compared with other foam materials.

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TL;DR: In this paper, the authors contrast the conventional view that CEO stock options aid corporate governance by reducing moral hazard with the proposal that they may subvert sound corporate governance, and propose a new set of rules for the allocation of stock options.
Abstract: We contrast the conventional view that CEO stock options aid corporate governance by reducing moral hazard with the proposal that CEO stock options may subvert sound corporate governance. Views wer...

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TL;DR: A review of the existing cross-cultural literature suggests that, although the contribution of the horizontal/vertical distinction is sometimes obscured by methods that conflate it with other dimensions, its impact is distinct from that associated with individualism-collectivism as discussed by the authors.

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TL;DR: In this article, Interactivity and its Facets Revisited: Theory and Empirical Test, the authors present an approach to evaluate the effectiveness of interaction and its facets.
Abstract: (2006). Interactivity and its Facets Revisited: Theory and Empirical Test. Journal of Advertising: Vol. 35, No. 4, pp. 35-52.

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TL;DR: It is reported that training rats in a simple fear conditioning procedure evokes a time-dependent increase in the phosphorylation of p70s6 kinase, a major direct downstream target of mTOR, indicating that local translational control at active synapses is required for the stability as well as the formation of long-term memory in this system.
Abstract: The mammalian target of rapamycin kinase (mTOR) regulates protein synthesis in neurons at the translational level through phosphorylation of several intracellular targets. Recent work in invertebrates indicates that mTOR-dependent translational control may be critical for the induction and maintenance of activity-dependent synaptic plasticity underlying memory formation. Here, we report that training rats in a simple fear conditioning procedure evokes a time-dependent increase in the phosphorylation of p70s6 kinase, a major direct downstream target of mTOR. When the activation of mTOR was prevented by posttraining injection of rapamycin into the amygdala, formation of the memory and the increase in p70s6 kinase phosphorylation was attenuated. Furthermore, when rapamycin was applied to the amygdala after the recall of a previously stored fear memory, subsequent retention was disrupted, indicating that local translational control at active synapses is required for the stability as well as the formation of long-term memory in this system.

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TL;DR: This article seeks to increase uniformity in liana inventories by providing specific recommendations for the determination of which taxa to include, the location of diameter measurement points on individual stems, the setting of minimum stem diameter cutoffs, the treatment of multiple-stemmed and rooted clonal groups, and the measurement of noncylindrical stems.
Abstract: A recent increase in published studies of lianas has been paralleled by a proliferation of protocols for censusing lianas. This article seeks to increase uniformity in liana inventories by providing specific recommendations for the determination of which taxa to include, the location of diameter measurement points on individual stems, the setting of minimum stem diameter cutoffs, the treatment of multiple-stemmed and rooted clonal groups, and the measurement of noncylindrical stems. Use of more uniform liana censusing protocols may facilitate comparison of independently collected data sets and further our understanding of global patterns in liana abundance, diversity, biomass, and dynamics.

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TL;DR: A model of Web query reformulation is developed using Saracevic's stratified model and identified eight distinct patterns: specified, generalized, parallel, building-block, dynamic, multitasking, recurrent, and format reformulation.
Abstract: This study examines the facets and patterns of multiple Web query reformulations with a focus on reformulation sequences Based on IR interaction models, it was presumed that query reformulation is the product of the interaction between the user and the IR system Query reformulation also reflects the interplay between the surface and deeper levels of user interaction Query logs were collected from a Web search engine through the selection of search sessions in which users submitted six or more unique queries per session The final data set was composed of 313 search sessions Three facets of query reformulation (content, format, and resource) as well as nine sub-facets were derived from the data In addition, analysis of modification sequences identified eight distinct patterns: specified, generalized, parallel, building-block, dynamic, multitasking, recurrent, and format reformulation Adapting Saracevic's stratified model, the authors develop a model of Web query reformulation based on the results of the study The implications for Web search engine design are finally discussed and the functions of an interactive reformulation tool are suggested

Journal ArticleDOI
TL;DR: In this article, the authors address some commonly used strategies to model disattenuated structural coefficients between latent variables, and show that when a single unidimensional scale is used to represent a latent...
Abstract: Structural equation modeling allows several methods of estimating the disattenuated association between 2 or more latent variables (i.e., the measurement model). In one common approach, measurement models are specified using item parcels as indicators of latent constructs. Item parcels versus original items are often used as indicators in these contexts to avoid estimation problems or solve issues associated with multivariate normality of the data. One concern associated with the use of item parceling is that no single "correct" approach exists to construct the parcels. Despite the controversy associated with selecting the most appropriate parceling method, less is understood with regard to how these methods influence the structural or path coefficients. By means of simulated and empirical data, this article addresses some commonly used strategies to model disattenuated structural coefficients between latent variables. Results revealed that when a single unidimensional scale is used to represent a latent ...