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Showing papers by "University of Wisconsin–Milwaukee published in 2018"


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1235 moreInstitutions (132)
TL;DR: This analysis expands upon previous analyses by working under the hypothesis that both bodies were neutron stars that are described by the same equation of state and have spins within the range observed in Galactic binary neutron stars.
Abstract: On 17 August 2017, the LIGO and Virgo observatories made the first direct detection of gravitational waves from the coalescence of a neutron star binary system. The detection of this gravitational-wave signal, GW170817, offers a novel opportunity to directly probe the properties of matter at the extreme conditions found in the interior of these stars. The initial, minimal-assumption analysis of the LIGO and Virgo data placed constraints on the tidal effects of the coalescing bodies, which were then translated to constraints on neutron star radii. Here, we expand upon previous analyses by working under the hypothesis that both bodies were neutron stars that are described by the same equation of state and have spins within the range observed in Galactic binary neutron stars. Our analysis employs two methods: the use of equation-of-state-insensitive relations between various macroscopic properties of the neutron stars and the use of an efficient parametrization of the defining function pðρÞ of the equation of state itself. From the LIGO and Virgo data alone and the first method, we measure the two neutron star radii as R1 ¼ 10.8 þ2.0 −1.7 km for the heavier star and R2 ¼ 10.7 þ2.1 −1.5 km for the lighter star at the 90% credible level. If we additionally require that the equation of state supports neutron stars with masses larger than 1.97 M⊙ as required from electromagnetic observations and employ the equation-of-state parametrization, we further constrain R1 ¼ 11.9 þ1.4 −1.4 km and R2 ¼ 11.9 þ1.4 −1.4 km at the 90% credible level. Finally, we obtain constraints on pðρÞ at supranuclear densities, with pressure at twice nuclear saturation density measured at 3.5 þ2.7 −1.7 × 1034 dyn cm−2 at the 90% level.

1,595 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, M. R. Abernathy3  +1135 moreInstitutions (139)
TL;DR: In this article, the authors present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves.
Abstract: We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy. The ability to localize the sources of the detected signals depends on the geographical distribution of the detectors and their relative sensitivity, and 90% credible regions can be as large as thousands of square degrees when only two sensitive detectors are operational. Determining the sky position of a significant fraction of detected signals to areas of 5– 20 deg2 requires at least three detectors of sensitivity within a factor of ∼2 of each other and with a broad frequency bandwidth. When all detectors, including KAGRA and the third LIGO detector in India, reach design sensitivity, a significant fraction of gravitational-wave signals will be localized to a few square degrees by gravitational-wave observations alone.

804 citations


Journal ArticleDOI
TL;DR: In this article, the authors presented high-precision timing data over time spans of up to 11 years for 45 millisecond pulsars observed as part of the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) project, aimed at detecting and characterizing low-frequency gravitational waves.
Abstract: We present high-precision timing data over time spans of up to 11 years for 45 millisecond pulsars observed as part of the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) project, aimed at detecting and characterizing low-frequency gravitational waves. The pulsars were observed with the Arecibo Observatory and/or the Green Bank Telescope at frequencies ranging from 327 MHz to 2.3 GHz. Most pulsars were observed with approximately monthly cadence, and six high-timing-precision pulsars were observed weekly. All were observed at widely separated frequencies at each observing epoch in order to fit for time-variable dispersion delays. We describe our methods for data processing, time-of-arrival (TOA) calculation, and the implementation of a new, automated method for removing outlier TOAs. We fit a timing model for each pulsar that includes spin, astrometric, and (for binary pulsars) orbital parameters; time-variable dispersion delays; and parameters that quantify pulse-profile evolution with frequency. The timing solutions provide three new parallax measurements, two new Shapiro delay measurements, and two new measurements of significant orbital-period variations. We fit models that characterize sources of noise for each pulsar. We find that 11 pulsars show significant red noise, with generally smaller spectral indices than typically measured for non-recycled pulsars, possibly suggesting a different origin. A companion paper uses these data to constrain the strength of the gravitational-wave background.

481 citations


Journal ArticleDOI
TL;DR: In this paper, an isotropic stochastic GWB in the newly released 11-year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) was searched for and the first pulsar-timing array (PTA) constraints that are robust against SSE errors were obtained.
Abstract: We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a GWB, we place constraints on a population of inspiraling supermassive black hole (SMBH) binaries, a network of decaying cosmic strings, and a primordial GWB. For the first time, we find that the GWB constraints are sensitive to the solar system ephemeris (SSE) model used and that SSE errors can mimic a GWB signal. We developed an approach that bridges systematic SSE differences, producing the first pulsar-timing array (PTA) constraints that are robust against SSE errors. We thus place a 95% upper limit on the GW-strain amplitude of A_(GWB) < 1.45 × 10^(−15) at a frequency of f = 1 yr^(−1) for a fiducial f^(−2/3) power-law spectrum and with interpulsar correlations modeled. This is a factor of ~2 improvement over the NANOGrav nine-year limit calculated using the same procedure. Previous PTA upper limits on the GWB (as well as their astrophysical and cosmological interpretations) will need revision in light of SSE systematic errors. We use our constraints to characterize the combined influence on the GWB of the stellar mass density in galactic cores, the eccentricity of SMBH binaries, and SMBH–galactic-bulge scaling relationships. We constrain the cosmic-string tension using recent simulations, yielding an SSE-marginalized 95% upper limit of Gμ < 5.3 × 10^(−11)—a factor of ~2 better than the published NANOGrav nine-year constraints. Our SSE-marginalized 95% upper limit on the energy density of a primordial GWB (for a radiation-dominated post-inflation universe) is Ω_(GWB)(f) h^2 < 3.4 × 10^(−10).

436 citations


Journal ArticleDOI
08 Feb 2018-Nature
TL;DR: The cocoon model explains the radio light curve of GW170817, as well as the γ-ray and X-ray emission (and possibly also the ultraviolet and optical emission), and is the model that is most consistent with the observational data.
Abstract: GW170817 was the first gravitational-wave detection of a binary neutron-star merger. It was accompanied by radiation across the electromagnetic spectrum and localized to the galaxy NGC 4993 at a distance of 40 megaparsecs. It has been proposed that the observed γ-ray, X-ray and radio emission is due to an ultra-relativistic jet being launched during the merger (and successfully breaking out of the surrounding material), directed away from our line of sight (off-axis). The presence of such a jet is predicted from models that posit neutron-star mergers as the drivers of short hard-γ-ray bursts. Here we report that the radio light curve of GW170817 has no direct signature of the afterglow of an off-axis jet. Although we cannot completely rule out the existence of a jet directed away from the line of sight, the observed γ-ray emission could not have originated from such a jet. Instead, the radio data require the existence of a mildly relativistic wide-angle outflow moving towards us. This outflow could be the high-velocity tail of the neutron-rich material that was ejected dynamically during the merger, or a cocoon of material that breaks out when a jet launched during the merger transfers its energy to the dynamical ejecta. Because the cocoon model explains the radio light curve of GW170817, as well as the γ-ray and X-ray emission (and possibly also the ultraviolet and optical emission), it is the model that is most consistent with the observational data. Cocoons may be a ubiquitous phenomenon produced in neutron-star mergers, giving rise to a hitherto unidentified population of radio, ultraviolet, X-ray and γ-ray transients in the local Universe.

383 citations


Journal ArticleDOI
TL;DR: Recovery of population genomes from surface ocean samples identified non-cyanobacterial diazotrophs that were widespread and abundant, including Proteobacteria and Planctomycetes, indicating their importance for nitrogen fixation in this environment.
Abstract: Nitrogen fixation in the surface ocean impacts global marine nitrogen bioavailability and thus microbial primary productivity. Until now, cyanobacterial populations have been viewed as the main suppliers of bioavailable nitrogen in this habitat. Although PCR amplicon surveys targeting the nitrogenase reductase gene have revealed the existence of diverse non-cyanobacterial diazotrophic populations, subsequent quantitative PCR surveys suggest that they generally occur in low abundance. Here, we use state-of-the-art metagenomic assembly and binning strategies to recover nearly one thousand non-redundant microbial population genomes from the TARA Oceans metagenomes. Among these, we provide the first genomic evidence for non-cyanobacterial diazotrophs inhabiting surface waters of the open ocean, which correspond to lineages within the Proteobacteria and, most strikingly, the Planctomycetes. Members of the latter phylum are prevalent in aquatic systems, but have never been linked to nitrogen fixation previously. Moreover, using genome-wide quantitative read recruitment, we demonstrate that the discovered diazotrophs were not only widespread but also remarkably abundant (up to 0.3% of metagenomic reads for a single population) in both the Pacific Ocean and the Atlantic Ocean northwest. Our results extend decades of PCR-based gene surveys, and substantiate the importance of heterotrophic bacteria in the fixation of nitrogen in the surface ocean.

369 citations


Journal ArticleDOI
TL;DR: This paper surveys the research developments on the Dial-A-Ride Problem (DARP) since 2007, and provides a classification of the problem variants and the solution methodologies, and references to benchmark instances.
Abstract: There has been a resurgence of interest in demand-responsive shared-ride systems, motivated by concerns for the environment and also new developments in technologies which enable new modes of operations. This paper surveys the research developments on the Dial-A-Ride Problem (DARP) since 2007. We provide a classification of the problem variants and the solution methodologies, and references to benchmark instances. We also present some application areas for the DARP, discuss some future trends and challenges, and indicate some possible directions for future research.

307 citations


Posted ContentDOI
Donald J. Hagler1, Sean N. Hatton1, Carolina Makowski2, M. Daniela Cornejo3, Damien A. Fair3, Anthony Steven Dick4, Matthew T. Sutherland4, B. J. Casey5, M Deanna6, Michael P. Harms6, Richard Watts5, James M. Bjork7, Hugh Garavan8, Laura Hilmer1, Christopher J. Pung1, Chelsea S. Sicat1, Joshua M. Kuperman1, Hauke Bartsch1, Feng Xue1, Mary M. Heitzeg9, Angela R. Laird4, Thanh T. Trinh1, Raul Gonzalez4, Susan F. Tapert1, Michael C. Riedel4, Lindsay M. Squeglia10, Luke W. Hyde9, Monica D. Rosenberg5, Eric Earl3, Katia D. Howlett11, Fiona C. Baker12, Mary E. Soules9, Jazmin Diaz1, Octavio Ruiz de Leon1, Wesley K. Thompson1, Michael C. Neale7, Megan M. Herting13, Elizabeth R. Sowell13, Ruben P. Alvarez14, Samuel W. Hawes4, Mariana Sanchez4, Jerzy Bodurka15, Florence J. Breslin15, Amanda Sheffield Morris15, Martin P. Paulus15, W. Kyle Simmons15, Jonathan R. Polimeni16, Andre van der Kouwe16, Andrew S. Nencka17, Kevin M. Gray10, Carlo Pierpaoli14, John A. Matochik14, Antonio Noronha14, Will M. Aklin11, Kevin P. Conway11, Meyer D. Glantz11, Elizabeth Hoffman11, Roger Little11, Marsha F. Lopez11, Vani Pariyadath11, Susan R.B. Weiss11, Dana L. Wolff-Hughes, Rebecca DelCarmen-Wiggins, Sarah W. Feldstein Ewing3, Oscar Miranda-Dominguez3, Bonnie J. Nagel3, Anders Perrone3, Darrick Sturgeon3, Aimee Goldstone12, Adolf Pfefferbaum12, Kilian M. Pohl12, Devin Prouty12, Kristina A. Uban1, Susan Y. Bookheimer1, Mirella Dapretto1, Adriana Galván1, Kara Bagot1, Jay N. Giedd1, M. Alejandra Infante1, Joanna Jacobus1, Kevin Patrick1, Paul D. Shilling1, Rahul S. Desikan1, Yi Li1, Leo P. Sugrue1, Marie T. Banich18, Naomi P. Friedman18, John K. Hewitt18, Christian J. Hopfer18, Joseph T. Sakai18, Jody Tanabe18, Linda B. Cottler19, Sara Jo Nixon19, Linda Chang20, Christine C. Cloak20, Thomas Ernst20, Gloria Reeves20, David N. Kennedy21, Steve Heeringa9, Scott Peltier9, John E. Schulenberg9, Chandra Sripada9, Robert A. Zucker9, William G. Iacono22, Monica Luciana22, Finnegan J. Calabro23, Duncan B. Clark23, David A. Lewis23, Beatriz Luna23, Claudiu Schirda23, Tufikameni Brima24, John J. Foxe24, Edward G. Freedman24, Daniel W. Mruzek24, Michael J. Mason25, Rebekah S. Huber26, Erin McGlade26, Andrew P. Prescot26, Perry F. Renshaw26, Deborah A. Yurgelun-Todd26, Nicholas Allgaier8, Julie A. Dumas8, Masha Y. Ivanova8, Alexandra Potter8, Paul Florsheim27, Christine L. Larson27, Krista M. Lisdahl27, Michael E. Charness28, Bernard F. Fuemmeler7, John M. Hettema7, Joel L. Steinberg7, Andrey P. Anokhin6, Paul E.A. Glaser6, Andrew C. Heath6, Pamela A. F. Madden6, Arielle R. Baskin-Sommers5, R. Todd Constable5, Steven Grant11, Gayathri J. Dowling11, Sandra A. Brown1, Terry L. Jernigan1, Anders M. Dale1 
04 Nov 2018-bioRxiv
TL;DR: The baseline neuroimaging processing and subject-level analysis methods used by the ABCD DAIC in the centralized processing and extraction of neuroanatomical and functional imaging phenotypes are described.
Abstract: The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The ABCD Study is a collaborative effort, including a Coordinating Center, 21 data acquisition sites across the United States, and a Data Analysis and Informatics Center (DAIC). The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data will provide a resource of unprecedented scale and depth for studying typical and atypical development. Here, we describe the baseline neuroimaging processing and subject-level analysis methods used by the ABCD DAIC in the centralized processing and extraction of neuroanatomical and functional imaging phenotypes. Neuroimaging processing and analyses include modality-specific corrections for distortions and motion, brain segmentation and cortical surface reconstruction derived from structural magnetic resonance imaging (sMRI), analysis of brain microstructure using diffusion MRI (dMRI), task-related analysis of functional MRI (fMRI), and functional connectivity analysis of resting-state fMRI.

276 citations


Journal ArticleDOI
Valérie Turcot1, Yingchang Lu2, Yingchang Lu3, Heather M. Highland4  +486 moreInstitutions (129)
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Abstract: Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.

252 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1141 moreInstitutions (126)
TL;DR: The total background may be detectable with a signal-to-noise-ratio of 3 after 40 months of total observation time, based on the expected timeline for Advanced LIGO and Virgo to reach their design sensitivity.
Abstract: The LIGO Scientific and Virgo Collaborations have announced the event GW170817, the first detection of gravitational waves from the coalescence of two neutron stars. The merger rate of binary neutron stars estimated from this event suggests that distant, unresolvable binary neutron stars create a significant astrophysical stochastic gravitational-wave background. The binary neutron star component will add to the contribution from binary black holes, increasing the amplitude of the total astrophysical background relative to previous expectations. In the Advanced LIGO-Virgo frequency band most sensitive to stochastic backgrounds (near 25 Hz), we predict a total astrophysical background with amplitude ΩGW(f=25 Hz)=1.8 +2.7 −1.3×10−9 with 90% confidence, compared with ΩGW(f=25 Hz)=1.1 +1.2 −0.7×10−9 from binary black holes alone. Assuming the most probable rate for compact binary mergers, we find that the total background may be detectable with a signal-to-noise-ratio of 3 after 40 months of total observation time, based on the expected timeline for Advanced LIGO and Virgo to reach their design sensitivity.

218 citations


Journal ArticleDOI
TL;DR: An overview of the ABCD Study Substance Use Workgroup is provided, the goals for the workgroup, rationale for the substance use battery, and includes details on the substanceuse module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points.

Journal ArticleDOI
TL;DR: Characteristics of portal nonusers were found to be more likely to be male, be on Medicaid, lack a regular provider, and have less than a college education, compared to users.
Abstract: Patient portals that provide secure online access to medical record information and provider communication can improve health care. Yet new technologies can exacerbate existing disparities. We analyzed information about 2,325 insured respondents to the nationally representative 2017 Health Information National Trends Survey to examine characteristics of portal nonusers and reasons for nonuse. Sixty-three percent reported not using a portal during the prior year. In multivariable analysis, we found that nonusers were more likely to be male, be on Medicaid, lack a regular provider, and have less than a college education, compared to users. Similar disparities existed in who reported being offered access to a portal, with nonwhites also less likely to report being offered access. Reasons for nonuse included the desire to speak directly to providers and privacy concerns, both of which require recognition of the important role of provider communication and patient-provider relationships.

Journal ArticleDOI
TL;DR: In this article, the authors combine new analysis of the stochastic gravitational wave background to be expected from cosmic strings with the latest pulsar timing array (PTA) limits to give an upper bound on the energy scale of the possible cosmic string network, G μ 1.5 × 10 − 11 at the 95% confidence level.

Journal ArticleDOI
Lang Wu1, Wei Shi2, Jirong Long1, Xingyi Guo1  +231 moreInstitutions (88)
TL;DR: A transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci at loci not yet reported for breast cancer.
Abstract: The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P < 5.82 × 10-6, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.

Journal ArticleDOI
TL;DR: By providing a clear framework for mating rules and how these rules affect speciation through maintaining or eroding barriers to gene flow among closely related species or populations, this work hopes to inspire greater alignment in the ways that both theoreticians and empiricists study mating rules.
Abstract: The large body of theory on speciation with gene flow has brought to light fundamental differences in the effects of two types of mating rules on speciation: preference/trait rules, in which divergence in both (female) preferences and (male) mating traits is necessary for assortment, and matching rules, in which individuals mate with like individuals on the basis of the presence of traits or alleles that they have in common. These rules can emerge from a variety of behavioral or other mechanisms in ways that are not always obvious. We discuss the theoretical properties of both types of rules and explain why speciation is generally thought to be more likely under matching rather than preference/trait rules. We furthermore discuss whether specific assortative mating mechanisms fall under a preference/trait or matching rule, present empirical evidence for these mechanisms, and propose empirical tests that could distinguish between them. The synthesis of the theoretical literature on these assortative mating rules with empirical studies of the mechanisms by which they act can provide important insights into the occurrence of speciation with gene flow. Finally, by providing a clear framework we hope to inspire greater alignment in the ways that both theoreticians and empiricists study mating rules and how these rules affect speciation through maintaining or eroding barriers to gene flow among closely related species or populations.

Journal ArticleDOI
TL;DR: This review focuses on the study of sex differences in the neurobiology of social behavior, memory, emotions, and recovery from brain injury, with particular emphasis on the role of estrogens in regulating forebrain function.

Journal ArticleDOI
TL;DR: A decentralized energy management framework to coordinate the power exchange between DS and MGs based on the alternating direction method of multipliers algorithm in a fully decentralized fashion is proposed.
Abstract: An increasing amount of distributed energy resources is being integrated into both distribution systems (DSs) and networked microgrids (MGs). The coordination among DSs and MGs becomes essential for DS operators and MG operators considering the high uncertainties of renewable energies and load demands. In this paper, we propose a decentralized energy management framework to coordinate the power exchange between DS and MGs based on the alternating direction method of multipliers algorithm in a fully decentralized fashion. The energy management model in each entity (DSs or MGs) is formulated using two-stage robust optimization to address the uncertainties of renewables and load demands. The problem is treated as a second order cone programming one based on a relaxed distflow model. Moreover, the robust model is solved by column and constraint generation algorithm, where cutting planes are introduced to ensure the exactness of second-order cone relaxation. Numerical results on a modified IEEE 33-bus system with three MGs validate the effectiveness of the proposed method.

Journal ArticleDOI
TL;DR: An adaptive management framework is offered to help conservation biologists and managers decide when genomics is likely to be effective in detecting local adaptation, and how to plan assessment and monitoring of adaptive variation to address conservation objectives.
Abstract: Identifying and monitoring locally adaptive genetic variation can have direct utility for conserving species at risk, especially when management may include actions such as translocations for restoration, genetic rescue, or assisted gene flow. However, genomic studies of local adaptation require careful planning to be successful, and in some cases may not be a worthwhile use of resources. Here, we offer an adaptive management framework to help conservation biologists and managers decide when genomics is likely to be effective in detecting local adaptation, and how to plan assessment and monitoring of adaptive variation to address conservation objectives. Studies of adaptive variation using genomic tools will inform conservation actions in many cases, including applications such as assisted gene flow and identifying conservation units. In others, assessing genetic diversity, inbreeding, and demographics using selectively neutral genetic markers may be most useful. And in some cases, local adaptation may be assessed more efficiently using alternative approaches such as common garden experiments. Here we identify key considerations of genomics studies of locally adaptive variation, provide a roadmap for successful collaborations with genomics experts including key issues for study design and data analysis, and offer guidelines for interpreting and using results from genomic assessments to inform monitoring programs and conservation actions. This article is protected by copyright. All rights reserved.

Journal ArticleDOI
TL;DR: A day-ahead EV charging scheduling based on an aggregative game model based on the pure strategy Nash equilibrium is proposed and an optimization method is developed to calculate the equilibrium of the game model through quadratic programming.
Abstract: The electric vehicle (EV) market has been growing rapidly around the world. With large scale deployment of EVs in power systems, both the grid and EV owners will benefit if the flexible demand of EV charging is properly managed through the electricity market. When EV charging demand is considerable in a grid, it will impact spot prices in the electricity market and consequently influence the charging scheduling itself. The interaction between the spot prices and the EV demand needs to be considered in the EV charging scheduling, otherwise it will lead to a higher charging cost. A day-ahead EV charging scheduling based on an aggregative game model is proposed in this paper. The impacts of the EV demand on the electricity prices are formulated with the game model in the scheduling considering possible actions of other EVs. The existence and uniqueness of the pure strategy Nash equilibrium are proved for the game. An optimization method is developed to calculate the equilibrium of the game model through quadratic programming. The optimal scheduling of the individual EV controller considering the actions of other EVs in the game is developed with the EV driving pattern distribution. Case studies with the proposed game model were carried out using real world driving data from the Danish National Travel Surveys. The impacts of the EV driving patterns and price forecasts on the EV demand with the proposed game model were also analysed.

Journal ArticleDOI
Max O. Wiedorn1, Dominik Oberthür, Richard Bean2, Robin Schubert2, Robin Schubert1, N. Werner1, Brian Abbey3, Martin Aepfelbacher1, Luigi Adriano, A. Allahgholi, Nasser Al-Qudami2, Jakob Andreasson4, Jakob Andreasson5, Jakob Andreasson6, Steve Aplin, Salah Awel1, Kartik Ayyer, Saša Bajt, Imrich Barák7, Sadia Bari, Johan Bielecki2, Sabine Botha1, Djelloul Boukhelef2, W. Brehm, Sandor Brockhauser8, Sandor Brockhauser2, Igor Cheviakov1, Matthew A. Coleman9, Francisco Cruz-Mazo10, Cyril Danilevski2, Connie Darmanin3, R. Bruce Doak11, M. Domaracky, Katerina Dörner2, Yang Du, Hans Fangohr2, Hans Fangohr12, Holger Fleckenstein, Matthias Frank9, Petra Fromme13, Alfonso M. Gañán-Calvo10, Y. Gevorkov14, Klaus Giewekemeyer2, Helen M. Ginn15, Heinz Graafsma16, Rita Graceffa2, Dominic Greiffenberg17, Lars Gumprecht, P. Gottlicher, Janos Hajdu5, Janos Hajdu6, Steffen Hauf2, Michael Heymann11, Susannah Holmes3, Daniel A. Horke1, Mark S. Hunter18, Siegfried Imlau, Alexander Kaukher2, Yoonhee Kim2, A. Klyuev, Juraj Knoska1, Bostjan Kobe19, Manuela Kuhn, Christopher Kupitz20, Jochen Küpper1, Janine Mia Lahey-Rudolph21, Torsten Laurus, Karoline Le Cong1, Romain Letrun2, P. Lourdu Xavier11, Luis Maia2, Filipe R. N. C. Maia22, Filipe R. N. C. Maia5, Valerio Mariani, Marc Messerschmidt2, Markus Metz, Davide Mezza17, Thomas Michelat2, Grant Mills2, Diana C. F. Monteiro1, Andrew J. Morgan, Kerstin Mühlig5, Anna Munke5, Astrid Münnich2, Julia Nette1, Keith A. Nugent3, Theresa Nuguid1, Allen M. Orville15, Suraj Pandey20, Gisel Pena, Pablo Villanueva-Perez, J. Poehlsen, Gianpietro Previtali2, Lars Redecke21, Lars Redecke1, Winnie Maria Riekehr21, Holger Rohde1, Adam Round2, Tatiana Safenreiter, Iosifina Sarrou, Tokushi Sato2, Marius Schmidt20, Bernd Schmitt17, R. Schonherr21, Joachim Schulz2, Jonas A. Sellberg23, M. Marvin Seibert5, Carolin Seuring1, Megan L. Shelby9, Robert L. Shoeman11, M. Sikorski2, Alessandro Silenzi2, Claudiu A. Stan24, Xintian Shi17, Stephan Stern2, Jola Sztuk-Dambietz2, Janusz Szuba2, Aleksandra Tolstikova, Martin Trebbin25, Martin Trebbin1, U. Trunk, Patrik Vagovic2, Thomas Ve26, Britta Weinhausen2, Thomas A. White, Krzysztof Wrona2, Chen Xu2, Oleksandr Yefanov, Nadia A. Zatsepin13, J. Zhang17, Markus Perbandt1, Adrian P. Mancuso2, Christian Betzel1, Christian Betzel2, Henry N. Chapman1, Anton Barty 
TL;DR: It is demonstrated that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore a β-lactamase structure.
Abstract: The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

Journal ArticleDOI
Tracy A. O'Mara1, Dylan M. Glubb1, Frédéric Amant2, Daniela Annibali2  +147 moreInstitutions (55)
TL;DR: This study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study and eQTL analysis reveals risk variants associate with reduced expression of negative regulators of oncogenic signal transduction proteins.
Abstract: Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

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TL;DR: In this paper, the authors present 2.9 GHz radio observations of GW170817 covering the period 125-200 days post-merger, taken with the Australia Telescope Compact Array (ATCA) and the Karl G. Jansky Very Large Array (VLA).
Abstract: We present 2–9 GHz radio observations of GW170817 covering the period 125–200 days post-merger, taken with the Australia Telescope Compact Array (ATCA) and the Karl G. Jansky Very Large Array (VLA). Our observations demonstrate that the radio afterglow peaked at 149 ± 2 days post-merger and is now declining in flux density. We see no evidence for evolution in the radio-only spectral index, which remains consistent with optically thin synchrotron emission connecting the radio, optical, and X-ray regimes. The peak implies a total energy in the synchrotron-emitting component of a few × 10^(50) erg. The temporal decay rate is most consistent with mildly or non-relativistic material and we do not see evidence for a very energetic off-axis jet, but we cannot distinguish between a lower-energy jet and more isotropic emission.

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TL;DR: In this article, the authors reported the discovery and initial follow-up of a double neutron star (DNS) system, PSR J1946+2052, with the Arecibo L-Band Feed Array pulsar (PALFA) survey.
Abstract: We report the discovery and initial follow-up of a double neutron star (DNS) system, PSR J1946+2052, with the Arecibo L-Band Feed Array pulsar (PALFA) survey. PSR J1946+2052 is a 17 ms pulsar in a 1.88 hr, eccentric (e = 0.06) orbit with a gsim1.2 M ⊙ companion. We have used the Jansky Very Large Array to localize PSR J1946+2052 to a precision of 0farcs09 using a new phase binning mode. We have searched multiwavelength catalogs for coincident sources but did not find any counterparts. The improved position enabled a measurement of the spin period derivative of the pulsar ($\dot{P}=9\pm 2\times {10}^{-19}$); the small inferred magnetic field strength at the surface (B S = 4 × 109 G) indicates that this pulsar has been recycled. This and the orbital eccentricity lead to the conclusion that PSR J1946+2052 is in a DNS system. Among all known radio pulsars in DNS systems, PSR J1946+2052 has the shortest orbital period and the shortest estimated merger timescale, 46 Myr; at that time it will display the largest spin effects on gravitational-wave waveforms of any such system discovered to date. We have measured the advance of periastron passage for this system, $\dot{\omega }=25.6\pm 0.3\,\deg \,{\mathrm{yr}}^{-1}$, implying a total system mass of only 2.50 ± 0.04 M ⊙, so it is among the lowest-mass DNS systems. This total mass measurement combined with the minimum companion mass constrains the pulsar mass to lesssim1.3 M ⊙.

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TL;DR: In this paper, the decay phase of the late-time radio light curve of the binary neutron star merger GW170817 is characterized with the upgraded Karl G. Jansky Very Large Array (GVLFA), the Australia Telescope Compact Array (ATCA), the MeerKAT telescope and the giant metrewave radio telescope.
Abstract: We present new 0.6–10 GHz observations of the binary neutron star merger GW170817 covering the period up to 300 days post-merger, taken with the upgraded Karl G. Jansky Very Large Array, the Australia Telescope Compact Array, the Giant Metrewave Radio Telescope and the MeerKAT telescope. We use these data to precisely characterize the decay phase of the late-time radio light curve. We find that the temporal decay is consistent with a power-law slope of t^(−2.2), and that the transition between the power-law rise and decay is relatively sharp. Such a slope cannot be produced by a quasi-isotropic (cocoon-dominated) outflow, but is instead the classic signature of a relativistic jet. This provides strong observational evidence that GW170817 produced a successful jet, and directly demonstrates the link between binary neutron star mergers and short-hard gamma-ray bursts. Using simple analytical arguments, we derive constraints on the geometry and the jet opening angle of GW170817. These results are consistent with those from our companion very long baseline interferometry paper, reporting superluminal motion in GW170817.

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01 Jul 2018-Nature
TL;DR: The accelerations of a pulsar and a white dwarf in a three-star system differ by at most a few parts per million, providing a much improved constraint on the universality of free fall.
Abstract: Einstein’s theory of gravity—the general theory of relativity1—is based on the universality of free fall, which specifies that all objects accelerate identically in an external gravitational field. In contrast to almost all alternative theories of gravity2, the strong equivalence principle of general relativity requires universality of free fall to apply even to bodies with strong self-gravity. Direct tests of this principle using Solar System bodies3,4 are limited by the weak self-gravity of the bodies, and tests using pulsar–white-dwarf binaries5,6 have been limited by the weak gravitational pull of the Milky Way. PSR J0337+1715 is a hierarchical system of three stars (a stellar triple system) in which a binary consisting of a millisecond radio pulsar and a white dwarf in a 1.6-day orbit is itself in a 327-day orbit with another white dwarf. This system permits a test that compares how the gravitational pull of the outer white dwarf affects the pulsar, which has strong self-gravity, and the inner white dwarf. Here we report that the accelerations of the pulsar and its nearby white-dwarf companion differ fractionally by no more than 2.6 × 10−6. For a rough comparison, our limit on the strong-field Nordtvedt parameter, which measures violation of the universality of free fall, is a factor of ten smaller than that obtained from (weak-field) Solar System tests3,4 and a factor of almost a thousand smaller than that obtained from other strong-field tests5,6.

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TL;DR: A two-stage robust optimization model is proposed to coordinate the on load tap changer ratios, reactive power compensators, and charge–discharge power of energy storage system to find a robust optimal solution to solve the robust coordinated optimization problem for active and reactive powers as a mixed integer second-order cone (SOC) programming problem.
Abstract: Active power dispatch and reactive power optimization problems are usually handled separately in active distribution systems, aiming at minimizing the total generation cost or transmission losses. However, the separate optimization cannot achieve a global optimum scheme in distribution system operations. Moreover, the significant relationship between the active power and reactive power may pose great challenges to distribution system operations due to the uncertain nature of load demands and intermittent renewable energy resources. In this paper, using the branch flow model-based relaxed optimal power flow, we formulate a robust coordinated optimization problem for active and reactive powers as a mixed integer second-order cone (SOC) programming problem. Furthermore, in order to address the uncertainties, a two-stage robust optimization model is proposed to coordinate the on load tap changer ratios, reactive power compensators, and charge–discharge power of energy storage system to find a robust optimal solution. Then the column-and-constraint generation algorithm is applied to solve the proposed robust two-stage optimization model. In the relaxed optimal power flow, a stricter cut is added to speed up the computation process of the SOC relaxation in order to guarantee the exactness for representative cases, such as those with high penetration of distributed energy resources. Numerical results based on the 33-bus and 69-bus systems verify the effectiveness of the proposed method.

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TL;DR: In this article, a carbon nanotube-backboned mesoporous carbon (TBMC) material for the impregnation of red P was designed and synthesized by a synchronic growth of resorcinol-formaldehyde resin/SiO2.

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B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, M. R. Abernathy3  +980 moreInstitutions (111)
TL;DR: The systematic removal of noisy data from analysis time is shown to improve the sensitivity of searches for compact binary coalescences, and the output of the PyCBC pipeline is used as a metric for improvement.
Abstract: The first observing run of Advanced LIGO spanned 4 months, from 12 September 2015 to 19 January 2016, during which gravitational waves were directly detected from two binary black hole systems, namely GW150914 and GW151226. Confident detection of gravitational waves requires an understanding of instrumental transients and artifacts that can reduce the sensitivity of a search. Studies of the quality of the detector data yield insights into the cause of instrumental artifacts and data quality vetoes specific to a search are produced to mitigate the effects of problematic data. In this paper, the systematic removal of noisy data from analysis time is shown to improve the sensitivity of searches for compact binary coalescences. The output of the PyCBC pipeline, which is a python-based code package used to search for gravitational wave signals from compact binary coalescences, is used as a metric for improvement. GW150914 was a loud enough signal that removing noisy data did not improve its significance. However, the removal of data with excess noise decreased the false alarm rate of GW151226 by more than two orders of magnitude, from 1 in 770 yr to less than 1 in 186 000 yr.

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TL;DR: In this paper, a thermally reduced graphene oxide-based field effect transistor (rGO FET) passivated with an ultrathin layer of Al2O3 was used for real-time detection of E. coli.

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TL;DR: A k ⋅ p model of the j = 3/2 fermions is proposed to explain how a dominant J = 3 septet pairing state is the simplest solution that naturally produces nodes in the mixed even-odd parity gap, and has strong potential for leading the development of a new series of topological superconductors.
Abstract: In all known fermionic superfluids, Cooper pairs are composed of spin-1/2 quasi-particles that pair to form either spin-singlet or spin-triplet bound states The "spin" of a Bloch electron, however, is fixed by the symmetries of the crystal and the atomic orbitals from which it is derived and, in some cases, can behave as if it were a spin-3/2 particle The superconducting state of such a system allows pairing beyond spin-triplet, with higher spin quasi-particles combining to form quintet or septet pairs We report evidence of unconventional superconductivity emerging from a spin-3/2 quasi-particle electronic structure in the half-Heusler semimetal YPtBi, a low-carrier density noncentrosymmetric cubic material with a high symmetry that preserves the p-like j = 3/2 manifold in the Bi-based Γ8 band in the presence of strong spin-orbit coupling With a striking linear temperature dependence of the London penetration depth, the existence of line nodes in the superconducting order parameter Δ is directly explained by a mixed-parity Cooper pairing model with high total angular momentum, consistent with a high-spin fermionic superfluid state We propose a k ⋅ p model of the j = 3/2 fermions to explain how a dominant J = 3 septet pairing state is the simplest solution that naturally produces nodes in the mixed even-odd parity gap Together with the underlying topologically nontrivial band structure, the unconventional pairing in this system represents a truly novel form of superfluidity that has strong potential for leading the development of a new series of topological superconductors