University of Wisconsin–Milwaukee

About: University of Wisconsin–Milwaukee is a education organization based out in Milwaukee, Wisconsin, United States. It is known for research contribution in the topics: Population & Gravitational wave. The organization has 11839 authors who have published 28034 publications receiving 936438 citations. The organization is also known as: UWM & University of Wisconsin-Milwaukee.

The MacNew Heart Disease health-related quality of life instrument: A summary

Abstract: Background: The measurement of health, the effects of disease, and the impact of health care include not only an indication of changes in disease frequency and severity but also an estimate of patients' perception of health status before and after treatment. One of the more important developments in health care in the past decade may be the recognition that the patient's perspective is as legitimate and valid as the clinician's in monitoring health care outcomes. This has lead to the development of instruments to quantify the patients' perception of their health status before and after treatment. Methods: We review evidence supporting the measurement properties of the MacNew Heart Disease Health-related Quality of Life [MacNew] Questionnaire which was designed to evaluate how daily activities and physical, emotional, and social functioning are affected by coronary heart disease and its treatment. Results: Reliability was demonstrated by using internal consistency and the intraclass correlation coefficients for the three domains in the Dutch, English, Farsi, German, and Spanish versions of the MacNew. With internal consistency and intraclass correlation coefficients =>0.73, reliability is high. Validity of the MacNew was examined with factor analysis and three core underlying factors, physical, emotional, and social, were identified, explaining 63.0 – 66.5% of the observed variance and replicated in the translations with psychometric data. Construct validity of the MacNew was further demonstrated by extensive substantiation of the logical relationships, defined a priori, between items and other comparison tools. The MacNew is responsive and sensitive to changes in HRQL following various interventions for patients with heart disease with 11 of 13 effect size statistics >0.80. Taking an average of 10 minutes or less to complete, the respondent-burden for the MacNew is low and its acceptability is demonstrated by response rates of over 90%. Normative data are available for patients with myocardial infarction, angina, and heart failure in the English version. Conclusion: The MacNew may be a valuable tool for assessing and evaluating health related quality of life in patients with heart disease.

The aging neuromuscular system and motor performance

Abstract: Age-related changes in the basic functional unit of the neuromuscular system, the motor unit, and its neural inputs have a profound effect on motor function, especially among the expanding number of old (older than ∼60 yr) and very old (older than ∼80 yr) adults. This review presents evidence that age-related changes in motor unit morphology and properties lead to impaired motor performance that includes 1) reduced maximal strength and power, slower contractile velocity, and increased fatigability; and 2) increased variability during and between motor tasks, including decreased force steadiness and increased variability of contraction velocity and torque over repeat contractions. The age-related increase in variability of motor performance with aging appears to involve reduced and more variable synaptic inputs that drive motor neuron activation, fewer and larger motor units, less stable neuromuscular junctions, lower and more variable motor unit action potential discharge rates, and smaller and slower skeletal muscle fibers that coexpress different myosin heavy chain isoforms in the muscle of older adults. Physical activity may modify motor unit properties and function in old men and women, although the effects on variability of motor performance are largely unknown. Many studies are of cross-sectional design, so there is a tremendous opportunity to perform high-impact and longitudinal studies along the continuum of aging that determine 1) the influence and cause of the increased variability with aging on functional performance tasks, and 2) whether lifestyle factors such as physical exercise can minimize this age-related variability in motor performance in the rapidly expanding numbers of very old adults.

Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains

Abstract: Sex determination can be robustly genetic, strongly environmental, or genetic subject to environmental perturbation. The genetic basis of sex determination is unknown for zebrafish (Danio rerio), a model for development and human health. We used RAD-tag population genomics to identify sex-linked polymorphisms. After verifying this “RAD-sex” method on medaka (Oryzias latipes), we studied two domesticated zebrafish strains (AB and TU), two natural laboratory strains (WIK and EKW), and two recent isolates from nature (NA and CB). All four natural strains had a single sex-linked region at the right tip of chromosome 4, enabling sex genotyping by PCR. Genotypes for the single nucleotide polymorphism (SNP) with the strongest statistical association to sex suggested that wild zebrafish have WZ/ZZ sex chromosomes. In natural strains, “male genotypes” became males and some “female genotypes” also became males, suggesting that the environment or genetic background can cause female-to-male sex reversal. Surprisingly, TU and AB lacked detectable sex-linked loci. Phylogenomics rooted on D. nigrofasciatus verified that all strains are monophyletic. Because AB and TU branched as a monophyletic clade, we could not rule out shared loss of the wild sex locus in a common ancestor despite their independent domestication. Mitochondrial DNA sequences showed that investigated strains represent only one of the three identified zebrafish haplogroups. Results suggest that zebrafish in nature possess a WZ/ZZ sex-determination mechanism with a major determinant lying near the right telomere of chromosome 4 that was modified during domestication. Strains providing the zebrafish reference genome lack key components of the natural sex-determination system but may have evolved variant sex-determining mechanisms during two decades in laboratory culture.

Bondholder Wealth Effects in Mergers and Acquisitions: New Evidence from the 1980s and 1990s

Abstract: We examine the wealth effects of mergers and acquisitions on target and acquiring firm bondholders for a sample of 940 offers involving 3,901 bonds during the period 1979-1997. We find strong evidence of a coinsurance effect for target bondholders, and we are able to trace target bondholder gains to a wealth-redistribution from target stockholders. During the announcement period, average acquirer excess bond returns are significantly negative while average target excess bond returns are significantly positive. For target bonds, the average excess return to below investment grade bonds is over 4%. Target bondholder returns are significantly larger when the merger reduces asset risk, when the target bond rating is below the acquirer bond rating, when the pre-merger leverage ratio of the target is greater than the pre-merger leverage ratio of the acquirer, and when the average target bond maturity is shorter than the average acquirer bond maturity. In addition, both target and acquirer excess bond returns are significantly smaller if the offer is hostile and are significantly larger in the 1990s, an era marked by increased bondholder event risk protection. Estimation of simultaneous equations models reveals that target stockholder dollar gains are significantly decreasing in target bondholder dollar gains, a result consistent with the view that target bondholder gains in takeovers come at the expense of target stockholders.

A Meta-Analysis Summarizing the Effects of Pornography II Aggression After Exposure

Abstract: This meta-analytic review examines the effect that exposure to pornography produces on aggressive behavior under laboratory conditions considering a variety of possible moderating conditions (level of sexual arousal, level of prior anger, type of pornography, gender of subject, gender of the target of aggression, and medium used to convey the material). The summary demonstrates a homogeneous set of results showing that pictorial nudity reduces subsequent aggressive behavior, that consumption of material depicting nonviolent sexual activity increases aggressive behavior, and that media depictions of violent sexual activity generates more aggression than those of nonviolent sexual activity. No other moderator variable produced homogeneous findings. The implications of the results for theoretical approaches to understanding the impact of pornography receives discussion, as do the limitations of such findings.