University of Wisconsin–Milwaukee

About: University of Wisconsin–Milwaukee is a education organization based out in Milwaukee, Wisconsin, United States. It is known for research contribution in the topics: Population & Gravitational wave. The organization has 11839 authors who have published 28034 publications receiving 936438 citations. The organization is also known as: UWM & University of Wisconsin-Milwaukee.

On risk, convenience, and Internet shopping behavior

Abstract: The past century experienced a proliferation of retail formats in the marketplace. However, as a new century begins, these retail formats are being threatened by the emergence of a new kind of store, the online or Internet store. From being almost a novelty in 1995, online retailing sales were expected to reach $7 billion by 2000 [9]. In this increasngly timeconstrained world, Internet stores allow consumers to shop from the convenience of remote locations. Yet most of these Internet stores are losing money [6]. Why is such counterintuitive phenomena prevailing? The explanation may lie in the risks associated with Internet shopping. These risks may arise because consumers are concerned about the security of transmitting credit card information over the Internet. Consumers may also be apprehensive about buying something without touching or feeling it and being unable to return it if it fails to meet their approval. Having said this, however, we must point out that consumers are buying goods on the Internet. This is reflected in the fact that total sales on the Internet are on the increase [8, 11]. Who are the consumers that are patronizing the Internet? Evidently, for them the perception of the risk associated with shopping on the Internet is low or is overshadowed by its relative convenience. This article attempts to determine why certain consumers are drawn to the Internet and why others are not. Since the pioneering research done by Becker [3], it has been accepted that the consumer maximizes his utility subject to not only income constraints but also time constraints. A consumer seeks out his best decision given that he has a limited budget of time and money. While purchasing a product from a store, a consumer has to expend both money and time. Therefore, the consumer patronizes the retail store where his total costs or the money and time spent in the entire process are the least. Since the util-

Testing general relativity with present and future astrophysical observations

Abstract: One century after its formulation, Einstein's general relativity (GR) has made remarkable predictions and turned out to be compatible with all experimental tests. Most of these tests probe the theory in the weak-field regime, and there are theoretical and experimental reasons to believe that GR should be modified when gravitational fields are strong and spacetime curvature is large. The best astrophysical laboratories to probe strong-field gravity are black holes and neutron stars, whether isolated or in binary systems. We review the motivations to consider extensions of GR. We present a (necessarily incomplete) catalog of modified theories of gravity for which strong-field predictions have been computed and contrasted to Einstein's theory, and we summarize our current understanding of the structure and dynamics of compact objects in these theories. We discuss current bounds on modified gravity from binary pulsar and cosmological observations, and we highlight the potential of future gravitational wave measurements to inform us on the behavior of gravity in the strong-field regime.

Quantized fields and particle creation in expanding universes. ii.

Abstract: Spin-0 fields of arbitrary mass and massless fields of arbitrary spin are considered. The equations governing the fields are the covariant generalizations of the special-relativistic free-field equations. The metric, which is not quantized, is that of a universe with an expanding (or contracting) Euclidean 3-space. The spin-0 field of arbitrary mass is quantized in the expanding universe by the canonical procedure. The quantization is consistent with the time development dictated by the equation of motion only when the boson commutation relations are imposed. This consistency requirement provides a new proof of the connection between spin and statistics. We show that the particle number is an adiabatic invariant, but not a strict constant of the motion. We obtain an expression for the average particle density as a function of the time, and show that particle creation occurs in pairs. The canonical creation and annihilation operators corresponding to physical particles during the expansion are specified. Thus, we do not use an S-matrix approach. We show that in a universe with flat 3-space containing only massless particles in equilibrium, there will be precisely no creation of massless particles as a result of the expansion, provided the Einstein field equations without the cosmological term are correct. Furthermore, in a dust-filled universe with flat 3-space there will be precisely no creation of massive spin-0 particles in the limit of infinite mass, again provided that the Einstein field equations are correct. Conversely, without assuming any particular equations, such as the Einstein equations, as governing the expansion of the universe, we obtain the familiar Friedmann expansions for the radiation-filled and the dust-filled universes with flat 3-space. We only make a very general and natural hypothesis connecting the particle creation rate with the macroscopic expansion of the universe. In one derivation, we assume that in an expansion of the universe in which a particular type of particle is predominant, the type of expansion approached after a long time will be such as to minimize the average creation rate of that particle. In another derivation, we use the assumption that the reaction of the particle creation back on the gravitational field will modify the expansion in such a way as to reduce, if possible, the creation rate. This connection between the particle creation and the Einstein equations is surprising because the Einstein equations themselves played no part at all in the derivation of the equations governing the particle creation. Finally, on the basis of a so-called infinite-mass approximation, we argue that in the present predominantly dust-filled universe, only massless particles of zero spin might possibly be produced in significant amounts by the present expansion. In this connection, we show that massless particles of arbitrary nonzero spin, such as photons or gravitons, are not created by the expansion, regardless of its form.

Association analysis identifies 65 new breast cancer risk loci

Abstract: Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

Predictions for the rates of compact binary coalescences observable by ground-based gravitational-wave detectors

Abstract: We present an up-to-date, comprehensive summary of the rates for all types of compact binary coalescence sources detectable by the initial and advanced versions of the ground-based gravitational-wave detectors LIGO and Virgo. Astrophysical estimates for compact-binary coalescence rates depend on a number of assumptions and unknown model parameters and are still uncertain. The most confident among these estimates are the rate predictions for coalescing binary neutron stars which are based on extrapolations from observed binary pulsars in our galaxy. These yield a likely coalescence rate of 100 Myr−1 per Milky Way Equivalent Galaxy (MWEG), although the rate could plausibly range from 1 Myr−1 MWEG−1 to 1000 Myr−1 MWEG−1 (Kalogera et al 2004 Astrophys. J. 601 L179; Kalogera et al 2004 Astrophys. J. 614 L137 (erratum)). We convert coalescence rates into detection rates based on data from the LIGO S5 and Virgo VSR2 science runs and projected sensitivities for our advanced detectors. Using the detector sensitivities derived from these data, we find a likely detection rate of 0.02 per year for Initial LIGO–Virgo interferometers, with a plausible range between 2 × 10−4 and 0.2 per year. The likely binary neutron–star detection rate for the Advanced LIGO–Virgo network increases to 40 events per year, with a range between 0.4 and 400 per year.