University of Wisconsin–Milwaukee

About: University of Wisconsin–Milwaukee is a education organization based out in Milwaukee, Wisconsin, United States. It is known for research contribution in the topics: Population & Gravitational wave. The organization has 11839 authors who have published 28034 publications receiving 936438 citations. The organization is also known as: UWM & University of Wisconsin-Milwaukee.

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Abstract: Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121*], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.

Searching for a mobile intruder in a polygonal region

Abstract: The problem of searching for a mobile intruder in a simple polygon by a single mobile searcher is considered. This paper investigates the capabilities of searchers having different degrees of visibility by introducing the searcher having k flashlights whose visibility is limited to k rays emanating from his position, and the searcher having a point light source who can see in all directions simultaneously. This paper presents necessary and sufficient conditions for a polygon to be searchable by various searchers. The paper also introduces a class of polygons for which the searcher having two flashlights is as capable as the searcher having a point light source, and it gives a simple necessary and sufficient condition for such polygons to be searchable by the searcher having two flashlights. The complexity of generating a search schedule under some of these conditions is also discussed. Many of the results are proved using chord systems that represent the visibility relations among the vertices and edges o...

Characterization of transient noise in Advanced LIGO relevant to gravitational wave signal GW150914

Abstract: On 14 September 2015, a gravitational wave signal from a coalescing black hole binary system was observed by the Advanced LIGO detectors. This paper describes the transient noise backgrounds used to determine the significance of the event (designated GW150914) and presents the results of investigations into potential correlated or uncorrelated sources of transient noise in the detectors around the time of the event. The detectors were operating nominally at the time of GW150914. We have ruled out environmental influences and non-Gaussian instrument noise at either LIGO detector as the cause of the observed gravitational wave signal.

A survey of dial-a-ride problems: Literature review and recent developments

Abstract: There has been a resurgence of interest in demand-responsive shared-ride systems, motivated by concerns for the environment and also new developments in technologies which enable new modes of operations. This paper surveys the research developments on the Dial-A-Ride Problem (DARP) since 2007. We provide a classification of the problem variants and the solution methodologies, and references to benchmark instances. We also present some application areas for the DARP, discuss some future trends and challenges, and indicate some possible directions for future research.

The NANOGrav Nine-year Data Set: Limits on the Isotropic Stochastic Gravitational Wave Background

Abstract: We compute upper limits on the nanohertz-frequency isotropic stochastic gravitational wave background (GWB) using the 9 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) collaboration. Well-tested Bayesian techniques are used to set upper limits on the dimensionless strain amplitude (at a frequency of 1 yr^(−1) for a GWB from supermassive black hole binaries of A_(gw) < 1.5 x 10^(-15). We also parameterize the GWB spectrum with a broken power-law model by placing priors on the strain amplitude derived from simulations of Sesana and McWilliams et al. Using Bayesian model selection we find that the data favor a broken power law to a pure power law with odds ratios of 2.2 and 22 to one for the Sesana and McWilliams prior models, respectively. Using the broken power-law analysis we construct posterior distributions on environmental factors that drive the binary to the GW-driven regime including the stellar mass density for stellar-scattering, mass accretion rate for circumbinary disk interaction, and orbital eccentricity for eccentric binaries, marking the first time that the shape of the GWB spectrum has been used to make astrophysical inferences. Returning to a power-law model, we place stringent limits on the energy density of relic GWs, Ω_(gw)(f)h^2 < 4.2 x 10^(-10). Our limit on the cosmic string GWB, Ω_(gw)(f)h^2 < 2.2 x 10^(-10), translates to a conservative limit on the cosmic string tension with Gµ < 3.3 x 10^(-8), a factor of four better than the joint Planck and high-l cosmic microwave background data from other experiments.