Showing papers by "University of Wollongong published in 2020"

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial

Abstract: Importance Clinical outcomes for glioblastoma remain poor. Treatment with immune checkpoint blockade has shown benefits in many cancer types. To our knowledge, data from a randomized phase 3 clinical trial evaluating a programmed death-1 (PD-1) inhibitor therapy for glioblastoma have not been reported. Objective To determine whether single-agent PD-1 blockade with nivolumab improves survival in patients with recurrent glioblastoma compared with bevacizumab. Design, Setting, and Participants In this open-label, randomized, phase 3 clinical trial, 439 patients with glioblastoma at first recurrence following standard radiation and temozolomide therapy were enrolled, and 369 were randomized. Patients were enrolled between September 2014 and May 2015. The median follow-up was 9.5 months at data cutoff of January 20, 2017. The study included 57 multicenter, multinational clinical sites. Interventions Patients were randomized 1:1 to nivolumab 3 mg/kg or bevacizumab 10 mg/kg every 2 weeks until confirmed disease progression, unacceptable toxic effects, or death. Main Outcomes and Measures The primary end point was overall survival (OS). Results A total of 369 patients were randomized to nivolumab (n = 184) or bevacizumab (n = 185). TheMGMTpromoter was methylated in 23.4% (43/184; nivolumab) and 22.7% (42/185; bevacizumab), unmethylated in 32.1% (59/184; nivolumab) and 36.2% (67/185; bevacizumab), and not reported in remaining patients. At median follow-up of 9.5 months, median OS (mOS) was comparable between groups: nivolumab, 9.8 months (95% CI, 8.2-11.8); bevacizumab, 10.0 months (95% CI, 9.0-11.8); HR, 1.04 (95% CI, 0.83-1.30);P = .76. The 12-month OS was 42% in both groups. The objective response rate was higher with bevacizumab (23.1%; 95% CI, 16.7%-30.5%) vs nivolumab (7.8%; 95% CI, 4.1%-13.3%). Grade 3/4 treatment-related adverse events (TRAEs) were similar between groups (nivolumab, 33/182 [18.1%]; bevacizumab, 25/165 [15.2%]), with no unexpected neurological TRAEs or deaths due to TRAEs. Conclusions and Relevance Although the primary end point was not met in this randomized clinical trial, mOS was comparable between nivolumab and bevacizumab in the overall patient population with recurrent glioblastoma. The safety profile of nivolumab in patients with glioblastoma was consistent with that in other tumor types. Trial Registration ClinicalTrials.gov Identifier:NCT02017717

Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.

Abstract: PURPOSEIn KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo plus pemetrexed-plati...

An In-Depth Study of Zn Metal Surface Chemistry for Advanced Aqueous Zn-Ion Batteries.

Abstract: Although Zn metal has been regarded as the most promising anode for aqueous batteries, it persistently suffers from serious side reactions and dendrite growth in mild electrolyte. Spontaneous Zn corrosion and hydrogen evolution damage the shelf life and calendar life of Zn-based batteries, severely affecting their industrial applications. Herein, a robust and homogeneous ZnS interphase is built in situ on the Zn surface by a vapor-solid strategy to enhance Zn reversibility. The thickness of the ZnS film is controlled via the treatment temperature, and the performance of the protected Zn electrode is optimized. The dense ZnS artificial layer obtained at 350 °C not only suppresses Zn corrosion by forming a physical barrier on the Zn surface, but also inhibits dendrite growth via guiding the Zn plating/stripping underneath the artificial layer. Accordingly, a side reaction-free and dendrite-free Zn electrode is developed, the effectiveness of which is also convincing in a MnO2 /ZnS@Zn full-cell with 87.6% capacity retention after 2500 cycles.

Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications.

Abstract: Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect vulnerable age groups. Studies of COVID-19 prevalence were collected by conducting an online search of published articles, preprints, and government reports that were publicly disseminated prior to 18 September 2020. The systematic review encompassed 113 studies, of which 27 studies (covering 34 geographical locations) satisfied the inclusion criteria and were included in the meta-analysis. Age-specific IFRs were computed using the prevalence data in conjunction with reported fatalities 4 weeks after the midpoint date of the study, reflecting typical lags in fatalities and reporting. Meta-regression procedures in Stata were used to analyze the infection fatality rate (IFR) by age. Our analysis finds a exponential relationship between age and IFR for COVID-19. The estimated age-specific IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85. Moreover, our results indicate that about 90% of the variation in population IFR across geographical locations reflects differences in the age composition of the population and the extent to which relatively vulnerable age groups were exposed to the virus. These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza. Moreover, the overall IFR for COVID-19 should not be viewed as a fixed parameter but as intrinsically linked to the age-specific pattern of infections. Consequently, public health measures to mitigate infections in older adults could substantially decrease total deaths.

Designing Dendrite-Free Zinc Anodes for Advanced Aqueous Zinc Batteries

Abstract: Zn metal has been regarded as the most promising anode for aqueous batteries due to its high capacity, low cost, and environmental benignity. Zn anode still suffers, however, from low Coulombic efficiency due to the side reactions and dendrite growth in slightly acidic electrolytes. Here, the Zn plating/stripping mechanism is thoroughly investigated in 1 m ZnSO4 electrolyte, demonstrating that the poor performance of Zn metal in mild electrolyte should be ascribed to the formation of a porous by-product (Zn4SO4(OH)6·xH2O) layer and serious dendrite growth. To suppress the side reactions and dendrite growth, a highly viscoelastic polyvinyl butyral film, functioning as an artificial solid/electrolyte interphase (SEI), is homogeneously deposited on the Zn surface via a simple spin-coating strategy. This dense artificial SEI film not only effectively blocks water from the Zn surface but also guides the uniform stripping/plating of Zn ions underneath the film due to its good adhesion, hydrophilicity, ionic conductivity, and mechanical strength. Consequently, this side-reaction-free and dendrite-free Zn electrode exhibits high cycling stability and enhanced Coulombic efficiency, which also contributes to enhancement of the full-cell performance when it is coupled with MnO2 and LiFePO4 cathodes.

Efficient Ammonia Electrosynthesis from Nitrate on Strained Ruthenium Nanoclusters

Abstract: The limitations of the Haber–Bosch reaction, particularly high-temperature operation, have ignited new interests in low-temperature ammonia-synthesis scenarios. Ambient N2 electroreduction is a com...

Unprecedented burn area of Australian mega forest fires

Abstract: To the Editor — Between September 2019 and early January 2020, around 5.8 million hectares of mainly temperate broadleaf forest were burned in New South Wales (NSW) and Victoria (VIC) in eastern Australia by a series of mega fires. Many of the fires have exceeded 100,000 ha and continued to burn for weeks after their ignition1. The Gospers Mountain fire near Sydney has burned more than 510,000 ha since ignition by lightning on 26 October 2019; it is the largest forest fire recorded in Australia and continues to burn in late January 2020. Eastern Australia’s temperate broadleaf forests, dominated by eucalypts, are among the most fire-prone in the world, and major fires are relatively common2,3, yet annually only small percentages of this forest biome burn, typically below 2% even in the more extreme fire seasons4,5. Are the 2019/20 forest fires unprecedented in scale, and are they the result of unparalleled fuel conditions? To address these questions, we analysed global data for remotely sensed burned area at 500 m resolution6, covering all major global forest biomes7 for the past 20 years (November 2000 to June 2019). We computed the annual burned area as a percentage of the continental sections of each forest biome between November 2000 and June 2019, and for the NSW plus VIC sections of the Australian ‘temperate broadleaf and mixed’ (TBLM) forest biome resulting from the 2019/20 forest fires. The TBLM forest biome7 in eastern Australia covers about 27 Mha, close to the median size of other continental forest biomes (26 Mha), with about half of that forest area located in NSW and a fifth in VIC. Our analysis substantiates that the 2019/20 forest fires have burned a globally unprecedented percentage of any continental forest biome: 21% of the Australian TBLM forest biome has so far been burned in a single season (Fig. 1). This figure contrasts sharply with annual burned area percentages for all other continental forest biomes4, which have been well below 5%, except for the Asian and African sections of the Tropical and Subtropical Dry Broadleaf forests, for which medians of 8–9% have been recorded (Fig. 1). We note that the burned area of 21% for the Australian TBLM forest biome is an underestimate, as forest fires in Tasmania this season were not included in our analysis, and additional forest area may burn over the remainder of the fire season. Why have the fires been so devastating this year? Fires in eucalypt forests propagate primarily through the litter layer8, and its dryness effectively acts as the ‘on/off switch’ for forest fire activity. Naturally occurring firebreaks, such as moist gullies, swamps or south-facing slopes, that normally dissect the forest landscape have dried out during the current widespread drought, affecting the probability of mega forest fire events in a highly nonlinear way9. In 2019, predicted litter moisture content across the eastern Australian TBLM forest biome was at record low levels, and the total surface area of forest exceeding critical flammability thresholds9 was larger and more prolonged than ever recorded in the past 30 years (Fig. 2). Thus extreme drought provided the preconditions

Ligand-assisted cation-exchange engineering for high-efficiency colloidal Cs1−xFAxPbI3 quantum dot solar cells with reduced phase segregation

Abstract: The mixed caesium and formamidinium lead triiodide perovskite system (Cs1−xFAxPbI3) in the form of quantum dots (QDs) offers a pathway towards stable perovskite-based photovoltaics and optoelectronics. However, it remains challenging to synthesize such multinary QDs with desirable properties for high-performance QD solar cells (QDSCs). Here we report an effective oleic acid (OA) ligand-assisted cation-exchange strategy that allows controllable synthesis of Cs1−xFAxPbI3 QDs across the whole composition range (x = 0–1), which is inaccessible in large-grain polycrystalline thin films. In an OA-rich environment, the cross-exchange of cations is facilitated, enabling rapid formation of Cs1−xFAxPbI3 QDs with reduced defect density. The hero Cs0.5FA0.5PbI3 QDSC achieves a certified record power conversion efficiency (PCE) of 16.6% with negligible hysteresis. We further demonstrate that the QD devices exhibit substantially enhanced photostability compared with their thin-film counterparts because of suppressed phase segregation, and they retain 94% of the original PCE under continuous 1-sun illumination for 600 h.

Coexisting Single-Atomic Fe and Ni Sites on Hierarchically Ordered Porous Carbon as a Highly Efficient ORR Electrocatalyst

Abstract: The development of oxygen reduction reaction (ORR) electrocatalysts based on earth-abundant nonprecious materials is critically important for sustainable large-scale applications of fuel cells and metal-air batteries. Herein, a hetero-single-atom (h-SA) ORR electrocatalyst is presented, which has atomically dispersed Fe and Ni coanchored to a microsized nitrogen-doped graphitic carbon support with unique trimodal-porous structure configured by highly ordered macropores interconnected through mesopores. Extended X-ray absorption fine structure spectra confirm that Fe- and Ni-SAs are affixed to the carbon support via FeN4 and NiN4 coordination bonds. The resultant Fe/Ni h-SA electrocatalyst exhibits an outstanding ORR activity, outperforming SA electrocatalysts with only Fe- or Ni-SAs, and the benchmark Pt/C. The obtained experimental results indicate that the achieved outstanding ORR performance results from the synergetic enhancement induced by the coexisting FeN4 and NiN4 sites, and the superior mass-transfer capability promoted by the trimodal-porous-structured carbon support.

Transparent ferroelectric crystals with ultrahigh piezoelectricity

Abstract: Transparent piezoelectrics are highly desirable for numerous hybrid ultrasound–optical devices ranging from photoacoustic imaging transducers to transparent actuators for haptic applications1–7. However, it is challenging to achieve high piezoelectricity and perfect transparency simultaneously because most high-performance piezoelectrics are ferroelectrics that contain high-density light-scattering domain walls. Here, through a combination of phase-field simulations and experiments, we demonstrate a relatively simple method of using an alternating-current electric field to engineer the domain structures of originally opaque rhombohedral Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) crystals to simultaneously generate near-perfect transparency, an ultrahigh piezoelectric coefficient d33 (greater than 2,100 picocoulombs per newton), an excellent electromechanical coupling factor k33 (about 94 per cent) and a large electro-optical coefficient γ33 (approximately 220 picometres per volt), which is far beyond the performance of the commonly used transparent ferroelectric crystal LiNbO3. We find that increasing the domain size leads to a higher d33 value for the [001]-oriented rhombohedral PMN-PT crystals, challenging the conventional wisdom that decreasing the domain size always results in higher piezoelectricity8–10. This work presents a paradigm for achieving high transparency and piezoelectricity by ferroelectric domain engineering, and we expect the transparent ferroelectric crystals reported here to provide a route to a wide range of hybrid device applications, such as medical imaging, self-energy-harvesting touch screens and invisible robotic devices. The use of alternating-current electric fields to control domain size in ferroelectric crystals affords excellent transparency, piezoelectricity and birefringence.

Heterogeneous Single‐Atom Catalysts for Electrochemical CO2 Reduction Reaction

Abstract: The electrochemical CO2 reduction reaction (CO2 RR) is of great importance to tackle the rising CO2 concentration in the atmosphere. The CO2 RR can be driven by renewable energy sources, producing precious chemicals and fuels, with the implementation of this process largely relying on the development of low-cost and efficient electrocatalysts. Recently, a range of heterogeneous and potentially low-cost single-atom catalysts (SACs) containing non-precious metals coordinated to earth-abundant elements have emerged as promising candidates for the CO2 RR. Unfortunately, the real catalytically active centers and the key factors that govern the catalytic performance of these SACs remain ambiguous. Here, this ambiguity is addressed by developing a fundamental understanding of the CO2 RR-to-CO process on SACs, as CO accounts for the major product from CO2 RR on SACs. The reaction mechanism, the rate-determining steps, and the key factors that control the activity and selectivity are analyzed from both experimental and theoretical studies. Then, the synthesis, characterization, and the CO2 RR performance of SACs are discussed. Finally, the challenges and future pathways are highlighted in the hope of guiding the design of the SACs to promote and understand the CO2 RR on SACs.

Grain-orientation-engineered multilayer ceramic capacitors for energy storage applications.

Abstract: Dielectric ceramics are highly desired for electronic systems owing to their fast discharge speed and excellent fatigue resistance. However, the low energy density resulting from the low breakdown electric field leads to inferior volumetric efficiency, which is the main challenge for practical applications of dielectric ceramics. Here, we propose a strategy to increase the breakdown electric field and thus enhance the energy storage density of polycrystalline ceramics by controlling grain orientation. We fabricated high-quality -textured Na0.5Bi0.5TiO3–Sr0.7Bi0.2TiO3 (NBT-SBT) ceramics, in which the strain induced by the electric field is substantially lowered, leading to a reduced failure probability and improved Weibull breakdown strength, on the order of 103 MV m−1, an ~65% enhancement compared to their randomly oriented counterparts. The recoverable energy density of -textured NBT-SBT multilayer ceramics is up to 21.5 J cm−3, outperforming state-of-the-art dielectric ceramics. The present research offers a route for designing dielectric ceramics with enhanced breakdown strength, which is expected to benefit a wide range of applications of dielectric ceramics for which high breakdown strength is required, such as high-voltage capacitors and electrocaloric solid-state cooling devices. The energy density of dielectric ceramic capacitors is limited by low breakdown fields. Here, by considering the anisotropy of electrostriction in perovskites, it is shown that -textured Na0.5Bi0.5TiO3–Sr0.7Bi0.2TiO3 ceramics can sustain higher electrical fields and achieve an energy density of 21.5 J cm−3.

Causes and consequences of eastern Australia's 2019-20 season of mega-fires.

Abstract: The 2019-20 fire season in eastern Australia is attracting considerable national and international attention. At the time of writing c. 3.8 million ha of mainly temperate forest have burnt in the state of New South Wales (NSW; NSW Rural Fire Service, 29/12/2019; Fig. 1a). Major blazes are also occurring in other states, including over 0.5 million ha in the state of Victoria (situated on the southern border of NSW).

Nanotechnology-based disinfectants and sensors for SARS-CoV-2.

Abstract: Nanotechnology-based antimicrobial and antiviral formulations can prevent SARS-CoV-2 viral dissemination, and highly sensitive biosensors and detection platforms may contribute to the detection and diagnosis of COVID-19.

The Cathode Choice for Commercialization of Sodium-Ion Batteries: Layered Transition Metal Oxides versus Prussian Blue Analogs

Abstract: With the unprecedentedly increasing demand for renewable and clean energy sources, the sodium-ion battery (SIB) is emerging as an alternative or complementary energy storage candidate to the present commercial lithium-ion battery due to the abundance and low cost of sodium resources. Layered transition metal oxides and Prussian blue analogs are reviewed in terms of their commercial potential as cathode materials for SIBs. The recent progress in research on their half cells and full cells for the ultimate application in SIBs are summarized. In addition, their electrochemical performance, suitability for scaling up, cost, and environmental concerns are compared in detail with a brief outlook on future prospects. It is anticipated that this review will inspire further development of layered transition metal oxides and Prussian blue analogs for SIBs, especially for their emerging commercialization.

Constructing phase boundary in AgNbO3 antiferroelectrics: pathway simultaneously achieving high energy density and efficiency

Abstract: Dielectric capacitors with high energy storage density (Wrec) and efficiency (η) are in great demand for high/pulsed power electronic systems, but the state-of-the-art lead-free dielectric materials are facing the challenge of increasing one parameter at the cost of the other. Herein, we report that high Wrec of 6.3 J cm-3 with η of 90% can be simultaneously achieved by constructing a room temperature M2–M3 phase boundary in (1-x)AgNbO3-xAgTaO3 solid solution system. The designed material exhibits high energy storage stability over a wide temperature range of 20–150 °C and excellent cycling reliability up to 106 cycles. All these merits achieved in the studied solid solution are attributed to the unique relaxor antiferroelectric features relevant to the local structure heterogeneity and antiferroelectric ordering, being confirmed by scanning transmission electron microscopy and synchrotron X-ray diffraction. This work provides a good paradigm for developing new lead-free dielectrics for high-power energy storage applications. Dielectric capacitors are widely used in electronic systems but they possess inferior energy density in comparison with other electrochemical energy storage. Here, the authors construct a diffused phase boundary to simultaneously achieve high energy storage density and efficiency in AgNbO3antiferroelectrics.

Reversible structural evolution of sodium-rich rhombohedral Prussian blue for sodium-ion batteries.

Abstract: Iron-based Prussian blue analogs are promising low-cost and easily prepared cathode materials for sodium-ion batteries. Their materials quality and electrochemical performance are heavily reliant on the precipitation process. Here we report a controllable precipitation method to synthesize high-performance Prussian blue for sodium-ion storage. Characterization of the nucleation and evolution processes of the highly crystalline Prussian blue microcubes reveals a rhombohedral structure that exhibits high initial Coulombic efficiency, excellent rate performance, and cycling properties. The phase transitions in the as-obtained material are investigated by synchrotron in situ powder X-ray diffraction, which shows highly reversible structural transformations between rhombohedral, cubic, and tetragonal structures upon sodium-ion (de)intercalations. Moreover, the Prussian blue material from a large-scale synthesis process shows stable cycling performance in a pouch full cell over 1000 times. We believe that this work could pave the way for the real application of Prussian blue materials in sodium-ion batteries. Here the authors deploy a scalable synthesis route to prepare sodium-rich Na2−xFeFe(CN)6 cathode materials for sodium-ion battery. The highly reversible structural evolution during cycling between rhombohedral, cubic and tetragonal phases is the key to enable the good performance.

Identifying Dense NiSe2 /CoSe2 Heterointerfaces Coupled with Surface High-Valence Bimetallic Sites for Synergistically Enhanced Oxygen Electrocatalysis.

Abstract: Constructing heterostructures with abundant interfaces is essential for integrating the multiple functionalities in single entities. Herein, the synthesis of NiSe2 /CoSe2 heterostructures with different interfacial densities via an innovative strategy of successive ion injection is reported. The resulting hybrid electrocatalyst with dense heterointerfaces exhibits superior electrocatalytic properties in an alkaline electrolyte, superior to other benchmarks and precious metal catalysts. Advanced synchrotron techniques, post structural characterizations, and density functional theory (DFT) simulations reveal that the introduction of atomic-level interfaces can lower the oxidation overpotential of bimetallic Ni and Co active sites (whereas Ni2+ can be more easily activated than Co2+ ) and induce the electronic interaction between the core selenides and surface in situ generated oxides/hydroxides, which play a critical role in synergistically reducing energetic barriers and accelerating reaction kinetics for catalyzing the oxygen evolution. Hence, the heterointerface structure facilitates the catalytic performance enhancement via increasing the intrinsic reactivity of metallic atoms and enhancing the synergistic effect between the inner selenides and surface oxidation species. This work not only complements the understanding on the origins of the activity of electrocatalysts based on metal selenides, but also sheds light on further surface and interfacial engineering of advanced hybrid materials.

Wildfire management in Mediterranean-type regions: paradigm change needed

Abstract: During the last decades, climate and land use changes led to an increased prevalence of megafires in Mediterranean-type climate regions (MCRs). Here, we argue that current wildfire management policies in MCRs are destined to fail. Focused on fire suppression, these policies largely ignore ongoing climate warming and landscape-scale buildup of fuels. The result is a "firefighting trap" that contributes to ongoing fuel accumulation precluding suppression under extreme fire weather, and resulting in more severe and larger fires. We believe that a "business as usual" approach to wildfire in MCRs will not solve the fire problem, and recommend that policy and expenditures be rebalanced between suppression and mitigation of the negative impacts of fire. This requires a paradigm shift: policy effectiveness should not be primarily measured as a function of area burned (as it usually is), but rather as a function of avoided socio-ecological damage and loss.

Self-regulation in childhood as a predictor of future outcomes: A meta-analytic review

Abstract: This meta-analysis explores whether self-regulation in childhood relates to concurrent and subsequent levels of achievement, interpersonal behaviors, mental health, and healthy living. A comprehensive literature search identified 150 studies that met inclusion criteria (745 effect sizes; total n = 215,212). Data were analyzed using inverse-variance weighted random effects meta-analysis. Mean effect sizes from 55 meta-analyses provided evidence that self-regulation relates to 25 discrete outcomes. Results showed that self-regulation in preschool (∼age 4) was positively associated with social competency, school engagement, and academic performance, and negatively associated with internalizing problems, peer victimization, and externalizing problems, in early school years (∼age 8). Self-regulation in early school years was positively related to academic achievement (math and literacy), and negatively related to externalizing problems (aggressive and criminal behavior), depressive symptoms, obesity, cigarette smoking and illicit drug use, in later school years (∼age 13). Results also showed that self-regulation in early school years was negatively related to unemployment, aggressive and criminal behavior, depression and anxiety, obesity, cigarette smoking, alcohol and substance abuse, and symptoms of physical illness in adulthood (∼age 38). Random effects metaregression identified self-regulation measurement as the most important moderator of pooled mean effects, with task-based assessments and teacher-report assessments often showing stronger associations than parent-report assessments. Overall, findings from this meta-analysis provide evidence that self-regulation in childhood can predict achievement, interpersonal behaviors, mental health, and healthy living in later life. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Coupling N2 and CO2 in H2O to synthesize urea under ambient conditions

Abstract: The use of nitrogen fertilizers has been estimated to have supported 27% of the world’s population over the past century. Urea (CO(NH2)2) is conventionally synthesized through two consecutive industrial processes, N2 + H2 → NH3 followed by NH3 + CO2 → urea. Both reactions operate under harsh conditions and consume more than 2% of the world’s energy. Urea synthesis consumes approximately 80% of the NH3 produced globally. Here we directly coupled N2 and CO2 in H2O to produce urea under ambient conditions. The process was carried out using an electrocatalyst consisting of PdCu alloy nanoparticles on TiO2 nanosheets. This coupling reaction occurs through the formation of C–N bonds via the thermodynamically spontaneous reaction between *N=N* and CO. Products were identified and quantified using isotope labelling and the mechanism investigated using isotope-labelled operando synchrotron-radiation Fourier transform infrared spectroscopy. A high rate of urea formation of 3.36 mmol g–1 h–1 and corresponding Faradic efficiency of 8.92% were measured at –0.4 V versus reversible hydrogen electrode. Conventionally, urea is synthesized via two consecutive processes, N2 + H2 → NH3 followed by NH3 + CO2. Now, an electrocatalyst consisting of PdCu alloy nanoparticles on TiO2 nanosheets has been shown to directly couple N2 and CO2 in H2O to produce urea under ambient conditions.

Disturbance Observer-Based Robust Control and Its Applications: 35th Anniversary Overview

Abstract: Disturbance observer (DOB) has been one of the most widely used robust control tools since it was proposed by Ohnishi in 1983. This paper introduces the origins of DOB and presents a survey of the major results on DOB-based robust control in the last 35 years. Furthermore, it explains DOB's analysis and synthesis techniques for linear and nonlinear systems by using a unified framework. In final section, this paper presents concluding remarks on DOB-based robust control and its engineering applications.

Everything counts in sending the right message: science-based messaging implications from the 2020 WHO guidelines on physical activity and sedentary behaviour.

Abstract: The World Health Organization (WHO) released the 2020 global guidelines on physical activity and sedentary behaviour. The new guidelines contain a significant change from the 2010 guidelines on physical activity for adults and older adults that has important implications for next-generation physical activity messaging: The removal of the need for aerobic activity to occur in bouts of at least 10 min duration. This change in the guidelines provides an opportunity to communicate in new ways that align with behavioural science, permitting physical activity communicators and promoters to better support people’s psychological needs, motivation, and ability to fit healthy levels of physical activity into their lives. The frames and messages we use to communicate about the guidelines matter because they influence whether activity is perceived as relevant, meaningful, and feasible – or not. When developing new physical activity communications there are some overarching principles, based on behavioural science, to keep in mind. Using established theory, this commentary aims to support the creation of more strategic frames and messages for increasing the value and integration of physical activity into daily living. Country-specific physical activity campaigns using these ideas will be discussed.