University of Wollongong

About: University of Wollongong is a education organization based out in Wollongong, New South Wales, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 15674 authors who have published 46658 publications receiving 1197471 citations. The organization is also known as: UOW & Wollongong University.

Photo-oxidation of proteins and its role in cataractogenesis.

Abstract: Proteins comprise approximately 68% of the dry weight of cells and tissues and are therefore potentially major targets for photo-oxidation. Two major types of processes can occur with proteins. The first of these involves direct photo-oxidation arising from the absorption of UV radiation by the protein, or bound chromophore groups, thereby generating excited states (singlet or triplets) or radicals via photo-ionisation. The second major process involves indirect oxidation of the protein via the formation and subsequent reactions of singlet oxygen generated by the transfer of energy to ground state (triplet) molecular oxygen by either protein-bound, or other, chromophores. The basic principles behind these mechanisms of photo-oxidation of amino acids, peptides and proteins and the potential selectivity of damage are discussed. Emphasis is placed primarily on the intermediates that are generated on amino acids and proteins, and the subsequent reactions of these species, and not the identity or chemistry of the sensitizer itself, unless the sensitizing group is itself intrinsic to the protein. A particular system is then discussed – the cataractous lens – where UV photo-oxidation may play a role in the aetiology of the disease, and tryptophan-derived metabolites act as UV filters.

The first climate refugees? Contesting global narratives of climate change in Tuvalu

Abstract: Climate change effects such as sea-level rise are almost certain. What these outcomes mean for different populations, however, is far less certain. Climate change is both a narrative and material phenomenon. In so being, understanding climate change requires broad conceptualisations that incorporate multiple voices and recognise the agency of vulnerable populations. In climate change discourse, climate mobility is often characterised as the production of ‘refugees’, with a tendency to discount long histories of ordinary mobility among affected populations. The case of Tuvalu in the Pacific juxtaposes migration as everyday practice with climate refugee narratives. This climate-exposed population is being problematically positioned to speak for an entire planet under threat. Tuvaluans are being used as the immediate evidence of displacement that the climate change crisis narrative seems to require. Those identified as imminent climate refugees are being held up like ventriloquists to present a particular (western) ‘crisis of nature’. Yet Tuvaluan conceptions of climate challenges and mobility practices show that more inclusive sets of concepts and tools are needed to equitably and effectively approach and characterise population mobility.