Institution
University of Würzburg
Education•Wurzburg, Bayern, Germany•
About: University of Würzburg is a education organization based out in Wurzburg, Bayern, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 31437 authors who have published 62203 publications receiving 2337033 citations. The organization is also known as: Julius-Maximilians-Universität Würzburg & Würzburg University.
Topics: Population, Gene, Immune system, Receptor, CAS Registry Number
Papers published on a yearly basis
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University of Lyon1, Los Angeles Biomedical Research Institute2, Federal University of São Paulo3, Emory University4, University of Trieste5, Vanderbilt University Medical Center6, University of California, Davis7, Karolinska Institutet8, French Institute of Health and Medical Research9, Baylor College of Medicine10, National Autonomous University of Mexico11, University of Würzburg12
TL;DR: An expert panel to review and develop standard terminologies and definitions related to wasting, cachexia, malnutrition, and inflammation in CKD and AKI recommends the term 'protein-energy wasting' for loss of body protein mass and fuel reserves.
1,584 citations
National Institutes of Health1, University of Nebraska Medical Center2, University of British Columbia3, University of Oslo4, Katholieke Universiteit Leuven5, University of Barcelona6, Oregon Health & Science University7, University of Arizona8, Cleveland Clinic9, University of Rochester10, University of Würzburg11, Bosch12, St Bartholomew's Hospital13
TL;DR: Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment, and a multivariate model created from three gene-expression signatures predicted survival both in patients who received CHOP and patients who receive R-CHOP.
Abstract: Background The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear. Methods We profiled gene expression in pretreatment biopsy specimens from 181 patients with diffuse large-B-cell lymphoma who received CHOP and 233 patients with this disease who received R-CHOP. A multivariate gene-expression–based survival-predictor model derived from a training group was tested in a validation group. Results A multivariate model created from three gene-expression signatures — termed “germinal-center B-cell,” “stromal-1,” and “stromal-2” — predicted survival both in patients who received CHOP and patients who received R-CHOP. The prognostically favorable stromal-1 signature reflected extracellular-matrix deposition and histiocytic infilt...
1,577 citations
University of Helsinki1, Mexican Social Security Institute2, University of New Mexico3, National Taiwan University4, Central Manchester University Hospitals NHS Foundation Trust5, State University of Campinas6, Telethon Institute for Child Health Research7, Chulalongkorn University8, University of the Philippines9, Royal Women's Hospital10, Queen Mary University of London11, University of Alberta12, University of Manitoba13, University of Würzburg14, Katholieke Universiteit Leuven15, Hull York Medical School16, GlaxoSmithKline17, University of Tampere18
TL;DR: The HPV- 16/18 AS04-adjuvanted vaccine showed high efficacy against CIN2+ associated with HPV-16/18 and non-vaccine oncogenic HPV types and substantial overall effect in cohorts that are relevant to universal mass vaccination and catch-up programmes.
1,569 citations
TL;DR: A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels.
Abstract: A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4l decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is mH=125.09±0.21 (stat)±0.11 (syst) GeV.
1,567 citations
TL;DR: These data definitively implicate perturbation of TGFβ signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events.
Abstract: We report heterozygous mutations in the genes encoding either type I or type II transforming growth factor β receptor in ten families with a newly described human phenotype that includes widespread perturbations in cardiovascular, craniofacial, neurocognitive and skeletal development. Despite evidence that receptors derived from selected mutated alleles cannot support TGFβ signal propagation, cells derived from individuals heterozygous with respect to these mutations did not show altered kinetics of the acute phase response to administered ligand. Furthermore, tissues derived from affected individuals showed increased expression of both collagen and connective tissue growth factor, as well as nuclear enrichment of phosphorylated Smad2, indicative of increased TGFβ signaling. These data definitively implicate perturbation of TGFβ signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events.
1,564 citations
Authors
Showing all 31653 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peer Bork | 206 | 697 | 245427 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| D. M. Strom | 176 | 3167 | 194314 |
| George P. Chrousos | 169 | 1612 | 120752 |
| David A. Bennett | 167 | 1142 | 109844 |
| Marc W. Kirschner | 162 | 457 | 102145 |
| Josef M. Penninger | 154 | 700 | 107295 |
| William A. Catterall | 154 | 536 | 83561 |
| Rui Zhang | 151 | 2625 | 107917 |
| Niels Birbaumer | 142 | 835 | 77853 |
| Kim Nasmyth | 142 | 294 | 59231 |
| James J. Gross | 139 | 529 | 100206 |
| Michael Schmitt | 134 | 2007 | 114667 |
| Jean-Luc Brédas | 134 | 1026 | 85803 |
| Alexander Schmidt | 134 | 1185 | 83879 |