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Institution

University of Würzburg

EducationWurzburg, Bayern, Germany
About: University of Würzburg is a education organization based out in Wurzburg, Bayern, Germany. It is known for research contribution in the topics: Population & CAS Registry Number. The organization has 31437 authors who have published 62203 publications receiving 2337033 citations. The organization is also known as: Julius-Maximilians-Universität Würzburg & Würzburg University.


Papers
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Journal ArticleDOI
TL;DR: It is suggested that a dynamic set of chemokines contributes to the spatially and temporally different infiltration of leukocyte subsets and thus integrates the inflammatory and reparative processes during wound repair.
Abstract: Healing of cutaneous wounds requires a complex integrated network of repair mechanisms, including the action of newly recruited leukocytes. Using a skin repair model in adult humans, we investigated the role chemokines play in sequential infiltration of leukocyte subsets during wound healing. At day 1 after injury, the C-X-C chemokines IL-8 and growth-related oncogene α are maximally expressed in the superficial wound bed and are spatially and temporally associated with neutrophil infiltration. IL-8 and growth-related oncogene α profiles also correlate with keratinocyte migration and subsequently subside after wound closure at day 4. Macrophage infiltration reaches the highest levels at day 2 and is paralleled by monocyte chemoattractant protein-1 mRNA expression in both the basal layer of the proliferative epidermis at the wound margins and mononuclear cells in the wound area. Other monocyte-attracting chemokines such as monocyte chemoattractant protein-3, macrophage inflammatory protein-1α and -1β, RANTES, and I309 are undetectable. At day 4, perivascular focal lymphocyte accumulation correlates with strong focal expression of the C-X-C chemokines Mig and IP-10. Our results suggest that a dynamic set of chemokines contributes to the spatially and temporally different infiltration of leukocyte subsets and thus integrates the inflammatory and reparative processes during wound repair.

431 citations

Journal ArticleDOI
TL;DR: In this review, a brief overview is given on the advantages and disadvantages of present pMRI methods in clinical applications, and examples from different daily clinical applications are shown.
Abstract: Fast imaging methods and the availability of required hardware for magnetic resonance tomography (MRT) have signifi- cantly reduced acquisition times from about an hour down to several minutes or seconds. With this development over the last 20 years, magnetic resonance imaging (MRI) has become one of the most im- portant instruments in clinical diagnosis. In recent years, the greatest progress in further increasing imaging speed has been the develop- ment of parallel MRI (pMRI). Within the last 3 years, parallel imag- ing methods have become commercially available, and therefore are now available for a broad clinical use. The basic feature of pMRI is a scan time reduction, applicable to nearly any available MRI method, while maintaining the contrast behavior without requiring higher gra- dient system performance. Because of its faster image acquisition, pMRI can in some cases even significantly improve image quality. In the last 10 years of pMRI development, several different pMRI re- construction methods have been set up which partially differ in their philosophy, in the mode of reconstruction as well in their advantages and drawbacks with regard to a successful image reconstruction. In this review, a brief overview is given on the advantages and disad- vantages of present pMRI methods in clinical applications, and ex- amples from different daily clinical applications are shown.

430 citations

Journal ArticleDOI
TL;DR: This review summarizes the current knowledge of platelet Ca2+ homeostasis with a focus on the newly identified Ca2- entry mechanisms.

429 citations

Journal ArticleDOI
TL;DR: Nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression are defined as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.
Abstract: Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate treatment at diagnosis. To define molecular criteria that might permit recognition of such cases, we compared the clinicopathologic features, gene expression, and genomic profile of patients who had indolent or conventional disease (iMCL or cMCL). Patients with iMCL displayed nonnodal leukemic disease with predominantly hypermutated IGVH and noncomplex karyotypes. iMCL and cMCL shared a common gene expression profile that differed from other leukemic lymphoid neoplasms. However, we identified a signature of 13 genes that was highly expressed in cMCL but underexpressed in iMCL. SOX11 was notable in this signature and we confirmed a restriction of SOX11 protein expression to cMCL. To validate the potential use of SOX11 as a biomarker for cMCL, we evaluated SOX11 protein expression in an independent series of 112 cases of MCL. Fifteen patients with SOX11-negative tumors exhibited more frequent nonnodal presentation and better survival compared with 97 patients with SOX11-positive MCL (5-year overall survival of 78% versus 36%, respectively; P = 0.001). In conclusion, we defined nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.

429 citations

Journal ArticleDOI
TL;DR: In this paper, the gamma-ray attenuation due to photon-photon scattering in high-redshift sources has been studied for three observed TeV-blazars (Mkn501, Mkn421, H1426+428).
Abstract: Bearing on the model for the time-dependent metagalactic radiation field developed in the first paper of this series, we compute the gamma-ray attenuation due to pair production in photon-photon scattering. Emphasis is on the effects of varying the star formation rate and the fraction of UV radiation assumed to escape from the star forming regions, the latter being important mainly for high-redshift sources. Conversely, we investigate how the metagalactic radiation field can be measured from the gamma-ray pair creation cutoff as a function of redshift, the Fazio-Stecker relation. For three observed TeV-blazars (Mkn501, Mkn421, H1426+428) we study the effects of gamma-ray attenuation on their spectra in detail.

429 citations


Authors

Showing all 31653 results

NameH-indexPapersCitations
Peer Bork206697245427
Cyrus Cooper2041869206782
D. M. Strom1763167194314
George P. Chrousos1691612120752
David A. Bennett1671142109844
Marc W. Kirschner162457102145
Josef M. Penninger154700107295
William A. Catterall15453683561
Rui Zhang1512625107917
Niels Birbaumer14283577853
Kim Nasmyth14229459231
James J. Gross139529100206
Michael Schmitt1342007114667
Jean-Luc Brédas134102685803
Alexander Schmidt134118583879
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023111
2022398
20212,960
20202,899
20192,714
20182,447