University of Würzburg

About: University of Würzburg is a education organization based out in Wurzburg, Bayern, Germany. It is known for research contribution in the topics: Population & CAS Registry Number. The organization has 31437 authors who have published 62203 publications receiving 2337033 citations. The organization is also known as: Julius-Maximilians-Universität Würzburg & Würzburg University.

Long noncoding RNA Chast promotes cardiac remodeling.

Abstract: Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac diseases is still limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are deregulated during pressure overload-induced cardiac hypertrophy in mice. Using stringent selection criteria, we identified Chast (cardiac hypertrophy-associated transcript) as a potential lncRNA candidate that influences cardiomyocyte hypertrophy. Cell fractionation experiments indicated that Chast is specifically up-regulated in cardiomyocytes in vivo in transverse aortic constriction (TAC)-operated mice. In accordance, CHAST homolog in humans was significantly up-regulated in hypertrophic heart tissue from aortic stenosis patients and in human embryonic stem cell-derived cardiomyocytes upon hypertrophic stimuli. Viral-based overexpression of Chast was sufficient to induce cardiomyocyte hypertrophy in vitro and in vivo. GapmeR-mediated silencing of Chast both prevented and attenuated TAC-induced pathological cardiac remodeling with no early signs on toxicological side effects. Mechanistically, Chast negatively regulated Pleckstrin homology domain-containing protein family M member 1 (opposite strand of Chast), impeding cardiomyocyte autophagy and driving hypertrophy. These results indicate that Chast can be a potential target to prevent cardiac remodeling and highlight a general role of lncRNAs in heart diseases.

Towards an understanding of Type Ia supernovae from a synthesis of theory and observations

Abstract: Motivated by the fact that calibrated light curves of Type Ia supernovae (SNe Ia) have become a major tool to determine the expansion history of the Universe, considerable attention has been given to, both, observations and models of these events over the past 15 years. Here, we summarize new observational constraints, address recent progress in modeling Type Ia supernovae by means of three-dimensional hydrodynamic simulations, and discuss several of the still open questions. It will be be shown that the new models have considerable predictive power which allows us to study observable properties such as light curves and spectra without adjustable non-physical parameters. This is a necessary requisite to improve our understanding of the explosion mechanism and to settle the question of the applicability of SNe Ia as distance indicators for cosmology. We explore the capabilities of the models by comparing them with observations and we show how such models can be applied to study the origin of the diversity of SNe Ia.