University of Würzburg

About: University of Würzburg is a education organization based out in Wurzburg, Bayern, Germany. It is known for research contribution in the topics: Population & CAS Registry Number. The organization has 31437 authors who have published 62203 publications receiving 2337033 citations. The organization is also known as: Julius-Maximilians-Universität Würzburg & Würzburg University.

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

Abstract: In the year 1902, I tacked onto the results of my experiments on the development of doubly fertilised sea urchin eggs the speculation that malignant tumours might be the consequence of a certain abnormal chromosome constitution, which in some circumstances can be generated by multipolar mitoses ([

Unite the People: Closing the Loop Between 3D and 2D Human Representations

Abstract: 3D models provide a common ground for different representations of human bodies. In turn, robust 2D estimation has proven to be a powerful tool to obtain 3D fits in-the-wild. However, depending on the level of detail, it can be hard to impossible to acquire labeled data for training 2D estimators on large scale. We propose a hybrid approach to this problem: with an extended version of the recently introduced SMPLify method, we obtain high quality 3D body model fits for multiple human pose datasets. Human annotators solely sort good and bad fits. This procedure leads to an initial dataset, UP-3D, with rich annotations. With a comprehensive set of experiments, we show how this data can be used to train discriminative models that produce results with an unprecedented level of detail: our models predict 31 segments and 91 landmark locations on the body. Using the 91 landmark pose estimator, we present state-of-the art results for 3D human pose and shape estimation using an order of magnitude less training data and without assumptions about gender or pose in the fitting procedure. We show that UP-3D can be enhanced with these improved fits to grow in quantity and quality, which makes the system deployable on large scale. The data, code and models are available for research purposes.

β2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

Abstract: The β 1 - and β 2 -adrenergic receptors (βARs) on the surface of cardiomyocytes mediate distinct effects on cardiac function and the development of heart failure by regulating production of the second messenger cyclic adenosine monophosphate (cAMP). The spatial localization in cardiomyocytes of these βARs, which are coupled to heterotrimeric guanine nucleotide–binding proteins (G proteins), and the functional implications of their localization have been unclear. We combined nanoscale live-cell scanning ion conductance and fluorescence resonance energy transfer microscopy techniques and found that, in cardiomyocytes from healthy adult rats and mice, spatially confined β 2 AR-induced cAMP signals are localized exclusively to the deep transverse tubules, whereas functional β 1 ARs are distributed across the entire cell surface. In cardiomyocytes derived from a rat model of chronic heart failure, β 2 ARs were redistributed from the transverse tubules to the cell crest, which led to diffuse receptor-mediated cAMP signaling. Thus, the redistribution of β 2 ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype.