University of Zagreb

About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

Abstract: Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88 x 10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10 x 10(-57)). After a correction for multiple comparisons (P-value, 2.2 x 10(-9)), we observed four novel loci significantly associated with phospholipids (PAQR9, AGPAT1, PKD2L1, PDXDC1) and two with sphingolipids (PLD2 and APOE) explaining up to 3.1% of the variance. Further analysis of the top findings with respect to within class molar proportions uncovered three additional loci for phospholipids (PNLIPRP2, PCDH20, and ABDH3) suggesting their involvement in either fatty acid elongation/saturation processes or fatty acid specific turnover mechanisms. Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1, FADS1-2-3, APOA1, PCDH20, LIPC, PDXDC1, SGPP1, APOE, LASS4, and PLD2) to the sphingolipid pathways. In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. In conclusion, our study identified nine novel phospho- and sphingolipid loci, substantially increasing our knowledge of the genetic basis for these traits.

Evolution of the specific star formation rate function at z< 1.4 Dissecting the mass-SFR plane in COSMOS and GOODS

Abstract: The relation between the stellar mass (M⋆) and the star formation rate (SFR) characterizes how the instantaneous star formation is determined by the galaxy past star formation history and by the growth of the dark matter structures. We deconstruct the M⋆-SFR plane by measuring the specific SFR functions in several stellar mass bins from z = 0.2 out to z = 1.4 (specific SFR = SFR/M⋆, noted sSFR). Our analysis is primary based on a 24 μm selected catalogue combining the COSMOS and GOODS surveys. We estimate the SFR by combining mid- and far-infrared data for 20500 galaxies. The sSFR functions are derived in four stellar mass bins within the range 9.5 < log (M⋆ /M⊙) < 11.5. First, we demonstrate the importance of taking into account selection effects when studying the M⋆-SFR relation. Secondly, we find a mass-dependent evolution of the median sSFR with redshift varying as sSFR ∝ (1 + z)^b, with b increasing from b = 2.88^(±0.12) to b = 3.78^(± 0.60) between M⋆ = 10^(9.75) M⊙ and M⋆ = 10^(11.1) M⊙, respectively. At low masses, this evolution is consistent with the cosmological accretion rate and predictions from semi-analytical models (SAM). This agreement breaks down for more massive galaxies showing the need for a more comprehensive description of the star formation history in massive galaxies. Third, we obtain that the shape of the sSFR function is invariant with time at z< 1.4 but depends on the mass. We observe a broadening of the sSFR function ranging from 0.28 dex at M⋆ = 10^(9.75) M⊙ to 0.46 dex at M⋆ = 10^(11.1) M⊙. Such increase in the intrinsic scatter of the M⋆-SFR relation suggests an increasing diversity ofstar formation histories (SFHs) as the stellar mass increases. Finally, we find a gradual decline of the sSFR with stellar mass as log _(10)(sSFR) ∝ −0.17M⋆. We discuss the numerous physical processes, as gas exhaustion in hot gas halos or secular evolution, which can gradually reduce the sSFR and increase the SFH diversity.

The Blazar TXS 0506+056 Associated with a High-energy Neutrino: Insights into Extragalactic Jets and Cosmic-Ray Acceleration

Abstract: A neutrino with energy similar to 290 TeV, IceCube-170922A, was detected in coincidence with the BL Lac object TXS. 0506+056 during enhanced gamma-ray activity, with chance coincidence being rejected at similar to 3 sigma level. We monitored the object in the very-high-energy (VHE) band with the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes for similar to 41 hr from 1.3 to 40.4 days after the neutrino detection. Day-timescale variability is clearly resolved. We interpret the quasi-simultaneous neutrino and broadband electromagnetic observations with a novel one-zone lepto-hadronic model, based on interactions of electrons and protons co-accelerated in the jet with external photons originating from a slow-moving plasma sheath surrounding the faster jet spine. We can reproduce the multiwavelength spectra of TXS 0506+056 with neutrino rate and energy compatible with IceCube-170922A, and with plausible values for the jet power of similar to 10(45) - 4 x 10(46) erg s(-1). The steep spectrum observed by MAGIC is concordant with internal gamma gamma absorption above similar to 100 GeV entailed by photohadronic production of a similar to 290 TeV neutrino, corroborating a genuine connection between the multi-messenger signals. In contrast to previous predictions of predominantly hadronic emission from neutrino sources, the gamma-rays can be mostly ascribed to inverse Compton upscattering of external photons by accelerated electrons. The X-ray and VHE bands provide crucial constraints on the emission from both accelerated electrons and protons. We infer that the maximum energy of protons in the jet comoving frame can be in the range similar to 10(14) - 10(18) eV.