University of Zagreb

About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

Abstract: Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2). We have previously shown that hemojuvelin is a co-receptor for bone morphogenetic proteins (BMPs) and that BMP signals regulate hepcidin expression and iron metabolism. However, the endogenous BMP regulator(s) of hepcidin in vivo is unknown. Here we show that compared with soluble hemojuvelin (HJV.Fc), the homologous DRAGON.Fc is a more potent inhibitor of BMP2 or BMP4 but a less potent inhibitor of BMP6 in vitro. In vivo, HJV.Fc or a neutralizing antibody to BMP6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect. Notably, Bmp6-null mice have a phenotype resembling hereditary hemochromatosis, with reduced hepcidin expression and tissue iron overload. Finally, we demonstrate a physical interaction between HJV.Fc and BMP6, and we show that BMP6 increases hepcidin expression and reduces serum iron in mice. These data support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expression and iron metabolism in vivo.

Performance of the ALICE experiment at the CERN LHC

Abstract: ALICE is the heavy-ion experiment at the CERN Large Hadron Collider. The experiment continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams. In this paper we describe the running environment and the data handling procedures, and discuss the performance of the ALICE detectors and analysis methods for various physics observables.

Adhesion and aggregation ability of probiotic strain Lactobacillus acidophilus M92

Abstract: B. K OS, J. SUSKOVIC ´ ,S. V U K O V I C´ ,M. SIMPRAGA, J. F RECE A ND S. M ATOSIC ´ . 2003. Aims: To investigate aggregation and adhesiveness of Lactobacillus acidophilus M92 to porcine ileal epithelial cells in vitro, and the influence of cell surface proteins on autoaggregation and adhesiveness of this strain. Methods and Results: Lactobacillus acidophilus M92 exhibits a strong autoaggregating phenotype and manifests a high degree of hydrophobicity determined by microbial adhesion to xylene. Aggregation and hydrophobicity were abolished upon exposure of the cells to pronase and pepsin. Sodium dodecyl sulphate polyacrylamide gel electrophoresis of cell surface proteins revealed the presence of potential surface layer (S-layer) proteins, approximated at 45 kDa, in L. acidophilus M92. The relationship between autoaggregation and adhesiveness to intestinal tissue was investigated by observing the adhesiveness of L. acidophilus M92 to porcine ileal epithelial cells. Removal of the S-layer proteins by extraction with 5 mol l )1 LiCl reduced autoaggregation and in vitro adhesion of this strain. Conclusions: These results demonstrate that there is relationship between autoaggregation and adhesiveness ability of L. acidophilus M92, mediated by proteinaceous components on the cell surface. Significance and Impact of the Study: This investigation has shown that L. acidophilus M92 has the ability to establish in the human gastrointestinal tract, which is an important determinant in the choice of probiotic strains.

Qualinet White Paper on Definitions of Quality of Experience

Abstract: This White Paper is a contribution of the European Network on Quality of Experience in Multimedia Systems and Services, Qualinet (COST Action IC 1003, see www.qualinet.eu), to the scientific discussion about the term "Quality of Experience" (QoE) and its underlying concepts. It resulted from the need to agree on a working definition for this term which facilitates the communication of ideas within a multidisciplinary group, where a joint interest around multimedia communication systems exists, however approached from different perspectives. Thus, the concepts and ideas cited in this paper mainly refer to the Quality of Experience of multimedia communication systems, but may be helpful also for other areas where QoE is an issue. The Network of Excellence (NoE) Qualinet aims at extending the notion of network-centric Quality of Service (QoS) in multimedia systems, by relying on the concept of Quality of Experience (QoE). The main scientific objective is the development of methodologies for subjective and objective quality metrics taking into account current and new trends in multimedia communication systems as witnessed by the appearance of new types of content and interactions. A substantial scientific impact on fragmented efforts carried out in this field will be achieved by coordinating the research of European experts under the catalytic COST umbrella. The White Paper has been compiled on the basis of a first open call for ideas which was launched for the February 2012 Qualinet Meeting held in Prague, Czech Republic. The ideas were presented as short statements during that meeting, reflecting the ideas of the persons listed under the headline "Contributors" in the previous section. During the Prague meeting, the ideas have been further discussed and consolidated in the form of a general structure of the present document. An open call for authors was issued at that meeting, to which the persons listed as "Authors" in the previous section have announced their willingness to contribute in the preparation of individual sections. For each section, a coordinating author has been assigned which coordinated the writing of that section, and which is underlined in the author list preceding each section. The individual sections were then integrated and aligned by an editing group (listed as "Editors" in the previous section), and the entire document was iterated with the entire group of authors. Furthermore, the draft text was discussed with the participants of the Dagstuhl Seminar 12181 "Quality of Experience: From User Perception to Instrumental Metrics" which was held in Schlos Dagstuhl, Germany, May 1-4 2012, and a number of changes were proposed, resulting in the present document. As a result of the writing process and the large number of contributors, authors and editors, the document will not reflect the opinion of each individual person at all points. Still, we hope that it is found to be useful for everybody working in the field of Quality of Experience of multimedia communication systems, and most probably also beyond that field.