University of Zagreb

About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.

Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches

Abstract: We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) using Nissl staining, AChE-histochemistry, PAS-Alcian blue histochemistry, Gallyas' silver impregnation, and immunocytochemistry for MAP2, synaptophysin, neurofilament, chondroitin sulfate, fibronectin, and myelin basic protein. The histological findings were correlated with in vivo MRI findings obtained in 30 age-matched fetuses, infants, and children. We analyzed developmental reorganization of major cellular (cell bodies, growing axons) and extracellular (extracellular matrix) components of the subplate and the developing cortex/white matter interface. We found that perinatal and postnatal reorganization of these tissue components is protracted (extending into the second year of life) and characterized by well-delineated, transient and previously undescribed structural and molecular changes at the cortex/white matter interface. The findings of this study are clinically relevant because they may inform and guide a proper interpretation of highly dynamic and hitherto puzzling changes of cortical thickness and cortical/white matter interface as described in current in vivo MRI studies.

Knowledge Management in the Fourth Industrial Revolution: Mapping the Literature and Scoping Future Avenues

Abstract: Due to increased competitive pressure, modern organizations tend to rely on knowledge and its exploitation to sustain a long-term advantage. This calls for a precise understanding of knowledge management (KM) processes and, specifically, how knowledge is created, shared/transferred, acquired, stored/retrieved, and applied throughout an organizational system. However, since the beginning of the new millennium, such KM processes have been deeply affected and molded by the advent of the fourth industrial revolution, also called Industry 4.0, which involves the interconnectedness of machines and their ability to learn and share data autonomously. For this reason, the present article investigates the intellectual structure and trends of KM in Industry 4.0. Bibliometric analysis and a systematic literature review are conducted on a total of 90 relevant articles. The results reveal six clusters of keywords, subsequently explored via a systematic literature review to identify potential stream of this emergent field and future research avenues capable of producing meaningful advances in managerial knowledge of Industry 4.0 and its consequences.

K(892)(*) resonance production in Au+Au and p+p collisions at root s(NN)=200 GeV

Abstract: The short-lived K(892)* resonance provides an efficient tool to probe properties of the hot and dense medium produced in relativistic heavy-ion collisions. We report measurements of K* in {radical}(s{sub NN})=200 GeV Au+Au and p+p collisions reconstructed via its hadronic decay channels K(892)*{sup 0}{yields}K{pi} and K(892)*{sup {+-}}{yields}K{sub S}{sup 0}{pi}{sup {+-}} using the STAR detector at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The K*{sup 0} mass has been studied as a function of p{sub T} in minimum bias p+p and central Au+Au collisions. The K* p{sub T} spectra for minimum bias p+p interactions and for Au+Au collisions in different centralities are presented. The K*/K yield ratios for all centralities in Au+Au collisions are found to be significantly lower than the ratio in minimum bias p+p collisions, indicating the importance of hadronic interactions between chemical and kinetic freeze-outs. A significant nonzero K*{sup 0} elliptic flow (v{sub 2}) is observed in Au+Au collisions and is compared to the K{sub S}{sup 0} and {lambda} v{sub 2}. The nuclear modification factor of K* at intermediate p{sub T} is similar to that of K{sub S}{sup 0} but different from {lambda}. This establishes a baryon-meson effect over a mass effect in the particle production atmore » intermediate p{sub T} (2

Weyl Points in Three-Dimensional Optical Lattices: Synthetic Magnetic Monopoles in Momentum Space.

Abstract: We show that a Hamiltonian with Weyl points can be realized for ultracold atoms using laser-assisted tunneling in three-dimensional optical lattices.

Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial

Abstract: To cite this article: Videler WJ, Badia L, Harvey RJ, Gane S, Georgalas C, van der Meulen FW, Menger DJ, Lehtonen MT, Toppila-Salmi SK, Vento SI, Hytonen M, Hellings PW, Kalogjera L, Lund VJ, Scadding G, Mullol J, Fokkens WJ. Lack of Efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy 2011; 66: 1457–1468. Abstract Background: In persistent chronic rhinosinusitis (CRS), conventional treatment is often insufficient. Long-term, low-dose administration of macrolides has been suggested as a treatment option. The MACS (Macrolides in chronic rhinosinusitis) study is a randomized placebo-controlled trial evaluating the efficacy of azithromycin (AZM) in CRS. Methods: We describe a group of patients with recalcitrant CRS with and without nasal polyps unresponsive to optimal medical and (in 92% also) surgical treatment. Patients were treated with AZM or placebo. AZM was given for 3 days at 500 mg during the first week, followed by 500 mg per week for the next 11 weeks. Patients were monitored until 3 months post-therapy. The assessments included Sino-Nasal Outcome Test-22 (SNOT-22), a Patient Response Rating Scale, Visual Analogue Scale (VAS), Short Form-36 (SF-36), rigid nasal endoscopy, peak nasal inspiratory flow (PNIF), Sniffin’ Sticks smell tests and endoscopically guided middle meatus cultures. Results: Sixty patients with a median age of 49 years were included. Fifty per cent had asthma and 58% had undergone revision sinus surgery. In the SNOT-22, Patient Response Rating Scale, VAS scores and SF-36, no significant difference between the AZM and the placebo groups was demonstrated. Nasal endoscopic findings, PNIF results, smell tests and microbiology showed no relevant significant differences between the groups either. Conclusion: At the investigated dose of AZM over 3 months, no significant benefit was found over placebo. Possible reasons could be disease severity in the investigated group, under-dosage of AZM and under-powering of the study. Therefore, more research is urgently required.