Institution
University of Zagreb
Education•Zagreb, Grad Zagreb, Croatia•
About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors explored the potential of magnetic resonance imaging (MRI) for tracing the developmental history of the most prominent cortical layer (the subplate zone) and other laminar compartments of the fetal cerebral wall between 15 and 36 weeks postovulation.
Abstract: The developing human cerebrum displays age-specific changes in its patterns of lamination. Among these, the subplate zone is the most prominent transient compartment because growing major afferent systems temporarily reside in this zone, establish synapses and take part in cellular interactions that are crucial for subsequent cortical development. We explored the potential of magnetic resonance imaging (MRI) for tracing the developmental history of the most prominent cortical layer (the subplate zone) and other laminar compartments of the fetal cerebral wall between 15 and 36 weeks post-ovulation. We found that changes in the MRI lamination pattern of the human fetal cerebral wall are predominantly caused by changes in the subplate zone. Histochemical staining of the extracellular matrix (ECM) enables selective visualization of the subplate zone and correlation with an increase in MRI signal intensity in the subplate zone and ingrowth and accumulation of thalamocortical and corticocortical afferents and their subsequent relocation to the cortical plate. Thus, dynamic changes in the MRI appearance of the subplate zone and histochemical staining of its ECM can be used as indirect parameters for an assessment of normal versus disturbed unfolding of crucial histogenetic events that are involved in prenatal shaping of the human cerebral cortex.
392 citations
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TL;DR: It is established that germline nonsense and frameshift variants in PALB2, but not in ATM or CHEK2, can also give rise to the same signature and epigenetic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signature 3.
Abstract: Biallelic inactivation of BRCA1 or BRCA2 is associated with a pattern of genome-wide mutations known as signature 3. By analyzing ∼1,000 breast cancer samples, we confirmed this association and established that germline nonsense and frameshift variants in PALB2, but not in ATM or CHEK2, can also give rise to the same signature. We were able to accurately classify missense BRCA1 or BRCA2 variants known to impair homologous recombination (HR) on the basis of this signature. Finally, we show that epigenetic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signature 3 and, in our data set, was highly enriched in basal-like breast cancers in young individuals of African descent.
390 citations
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01 Jan 2014TL;DR: The mission of EMBS is to advance the application of engineering sciences and technology to medicine and biology, promote the profession, provide global leadership for the benefit of its members and humanity by disseminating knowledge, set standards, foster professional development, and recognize excellence.
Abstract: IEEE Engineering in Medicine and Biology Society (EMBS) is the world’s largest international society of Biomedical Engineers. Its 8,300 members reside in some 70 countries around the world, forming a true global connection, bringing together fascinating people, practices, information, ideas, opinion, and fellowship from one of science’s fasting growing fields. The mission of EMBS is to advance the application of engineering sciences and technology to medicine and biology, promote the profession, provide global leadership for the benefit of its members and humanity by disseminating knowledge, set standards, foster professional development, and recognize excellence.
389 citations
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TL;DR: In this paper, the authors present an overview of AGN multi-wavelength properties with the aim of painting their "big picture" through observations in each electromagnetic band from radio to gamma-gamma -rays as well as AGN variability.
Abstract: Active galactic nuclei (AGN) are energetic astrophysical sources powered by accretion onto supermassive black holes in galaxies, and present unique observational signatures that cover the full electromagnetic spectrum over more than twenty orders of magnitude in frequency. The rich phenomenology of AGN has resulted in a large number of different “flavours” in the literature that now comprise a complex and confusing AGN “zoo”. It is increasingly clear that these classifications are only partially related to intrinsic differences between AGN and primarily reflect variations in a relatively small number of astrophysical parameters as well the method by which each class of AGN is selected. Taken together, observations in different electromagnetic bands as well as variations over time provide complementary windows on the physics of different sub-structures in the AGN. In this review, we present an overview of AGN multi-wavelength properties with the aim of painting their “big picture” through observations in each electromagnetic band from radio to $$\gamma $$
-rays as well as AGN variability. We address what we can learn from each observational method, the impact of selection effects, the physics behind the emission at each wavelength, and the potential for future studies. To conclude, we use these observations to piece together the basic architecture of AGN, discuss our current understanding of unification models, and highlight some open questions that present opportunities for future observational and theoretical progress.
384 citations
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University of Zurich1, University of Notre Dame2, CERN3, Brookhaven National Laboratory4, Durham University5, University of Hamburg6, Max Planck Society7, Autonomous University of Madrid8, University of Victoria9, Technische Universität München10, University of Cagliari11, Instituto Superior Técnico12, University of British Columbia13, University of Valencia14, International School for Advanced Studies15, University of Warsaw16, University of Lyon17, Yale University18, University of Manchester19, University of Pisa20, RWTH Aachen University21, University of Wisconsin-Madison22, University of Sussex23, University of Tokyo24, Argonne National Laboratory25, Helsinki Institute of Physics26, University of Oregon27, University of Zagreb28, KEK29, University of Southampton30, Paul Scherrer Institute31, Petersburg Nuclear Physics Institute32, University of California33, University of Paris34, University of Rome Tor Vergata35, Bulgarian Academy of Sciences36, University of Salento37, Boston University38, University of Würzburg39, International Centre for Theoretical Physics40, University of Murcia41, University of Michigan42, Indian Institute of Science43
TL;DR: In this article, the authors discuss the theoretical, phenomenological and experimental issues related to flavor phenomena in the charged lepton sector and in flavor conserving CP-violating processes.
Abstract: This chapter of the report of the “Flavor in the era of the LHC” Workshop discusses the theoretical, phenomenological and experimental issues related to flavor phenomena in the charged lepton sector and in flavor conserving CP-violating processes. We review the current experimental limits and the main theoretical models for the flavor structure of fundamental particles. We analyze the phenomenological consequences of the available data, setting constraints on explicit models beyond the standard model, presenting benchmarks for the discovery potential of forthcoming measurements both at the LHC and at low energy, and exploring options for possible future experiments.
384 citations
Authors
Showing all 22096 results
Name | H-index | Papers | Citations |
---|---|---|---|
Harry Campbell | 150 | 897 | 115457 |
Joseph R. Ecker | 148 | 381 | 94860 |
Igor Rudan | 142 | 658 | 103659 |
Nikola Godinovic | 138 | 1469 | 100018 |
Ivica Puljak | 134 | 1436 | 97548 |
Damir Lelas | 133 | 1354 | 93354 |
Željko Ivezić | 129 | 344 | 84365 |
Piotr Ponikowski | 120 | 762 | 131682 |
Marin Soljacic | 117 | 764 | 51444 |
Ivan Dikic | 107 | 359 | 52088 |
Ozren Polasek | 102 | 436 | 52674 |
Mordechai Segev | 99 | 729 | 40073 |
Srdan Verstovsek | 96 | 1045 | 38936 |
Segev BenZvi | 95 | 482 | 32127 |
Mirko Planinic | 94 | 467 | 31957 |