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Institution

University of Zagreb

EducationZagreb, Grad Zagreb, Croatia
About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.


Papers
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Journal ArticleDOI
TL;DR: The present article discusses the potential implications of adopting the ACC/AHA guidelines on patient care in Europe and beyond and concludes with the opinion that the ESC/EAS guidelines from 2011 seem to be the most wide ranging, pragmatic and appropriate choice for European countries.
Abstract: Atherosclerotic cardiovascular disease is the most important public health problem of our time in both Europe and the rest of the world, accounting for the greatest expenditure in most healthcare budgets. Achieving consistency of clinical care, incorporating new evidence and their synthesis into practical recommendations for clinicians is the task of various guideline committees throughout the world. Any change in a set of guidelines therefore can have far reaching consequences, particularly if they appear to be at variance with the existing guidelines. The present article discusses the recent American College of Cardiology (ACC)/American Heart Association (AHA) guidelines 2013 on the control of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults. When compared with the ESC/EAS guidelines on lipid modification in 2011, the ACC/AHA guidelines of 2013 differ markedly. Specifically, (i) the scope is limited to randomized trials only, which excludes a significant body of data and promotes essentially a statin centric approach only; (ii) the abolition of low-density lipoprotein cholesterol (LDL-C) targets in favour of specific statin regimens that produce a 30-50% reduction in LDL-C we believe will confuse many physicians and miss the opportunity for medication adherence and patient engagement in self-management; (iii) the absence of target LDL-C levels in very high-risk patients with high absolute risk or residual risk factors will discourage clinicians to consider the addition of lipid modification treatments and individualize patient care; (iv) a reduction in the threshold for treatment in primary prevention will result in a greater number of patients being prescribed statin therapy, which is potentially good in young patients with high life time risk, but will result in a very large number of older patients offered therapy; and (v) the mixed pool risk calculator used to asses CVD risk in the guidelines for primary prevention has not been fully evaluated. This article discusses the potential implications of adopting the ACC/AHA guidelines on patient care in Europe and beyond and concludes with the opinion that the ESC/EAS guidelines from 2011 seem to be the most wide ranging, pragmatic and appropriate choice for European countries.

285 citations

Journal ArticleDOI
TL;DR: Data implied that blueberries, blackberries, cranberries, and grapes can be useful for replacing/decreasing synthetic antioxidants in meat products, since meats are highly susceptible to oxidation.

285 citations

Journal ArticleDOI
TL;DR: It is shown that the Gray phenotype is caused by a 4.6-kb duplication in intron 6 of STX17 (syntaxin-17) that constitutes a cis-acting regulatory mutation that is overexpressed in melanomas from Gray horses.
Abstract: In horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4.6-kb duplication in intron 6 of STX17 (syntaxin-17) that constitutes a cis-acting regulatory mutation. Both STX17 and the neighboring NR4A3 gene are overexpressed in melanomas from Gray horses. Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses. The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in domestic animals.

285 citations

Journal ArticleDOI
Leszek Adamczyk1, J. K. Adkins2, G. Agakishiev3, Madan M. Aggarwal4  +350 moreInstitutions (52)
TL;DR: These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models and show nonmonotonic behavior as a function of collision energy.
Abstract: We report the first measurements of the moments-mean (M), variance (sigma(2)), skewness (S), and kurtosis (kappa)-of the net-charge multiplicity distributions at midrapidity in Au + Au collisions at seven energies, ranging from root s(NN) = 7.7 to 200 GeV, as a part of the Beam Energy Scan program at RHIC. The moments are related to the thermodynamic susceptibilities of net charge, and are sensitive to the location of the QCD critical point. We compare the products of the moments, sigma(2)/M, S sigma, and kappa sigma(2), with the expectations from Poisson and negative binomial distributions (NBDs). The S sigma values deviate from the Poisson baseline and are close to the NBD baseline, while the kappa sigma(2) values tend to lie between the two. Within the present uncertainties, our data do not show nonmonotonic behavior as a function of collision energy. These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models.

285 citations

Journal ArticleDOI
TL;DR: The use of active packaging and natural antioxidants, the active film development techniques, as well as the use of biopolymers as substitutes for synthetic polymers and their direct application in the meat industry are given.

284 citations


Authors

Showing all 22096 results

NameH-indexPapersCitations
Harry Campbell150897115457
Joseph R. Ecker14838194860
Igor Rudan142658103659
Nikola Godinovic1381469100018
Ivica Puljak134143697548
Damir Lelas133135493354
Željko Ivezić12934484365
Piotr Ponikowski120762131682
Marin Soljacic11776451444
Ivan Dikic10735952088
Ozren Polasek10243652674
Mordechai Segev9972940073
Srdan Verstovsek96104538936
Segev BenZvi9548232127
Mirko Planinic9446731957
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023119
2022525
20213,277
20203,360
20193,176
20183,042