Institution
University of Zagreb
Education•Zagreb, Grad Zagreb, Croatia•
About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Increasing age emerges as a major determinant of the clinical characteristics of infective endocarditis, and lower rates of surgical treatment and high mortality are the most prominent features of elderly patients with IE.
Abstract: Results: Elderly patients reported more frequently a hospitalization or an invasive procedure before IE onset. Diabetes mellitus and genitourinary and gastrointestinal cancer were the major predisposing conditions. Blood culture yield was higher among elderly patients with IE. The leading causative organism was Staphylococcus aureus, with a higher rate of methicillin resistance.Streptococcusbovis and enterococci were also significantly more prevalent. The clinical presentation of elderly patients with IE was remarkable for lower rates of embolism, immune-mediated phenomena, or septic complications. At both echocardiography and surgery, fewer vegetations and more abscesses were found, and the gain in the diagnostic yield of transesophageal echocardiography was significantly larger. Significantly fewer elderly patients underwent cardiac surgery (38.9% vs 53.5%; P.001). Elderly patients with IE showed a higher rate of in-hospital death (24.9% vs 12.8%; P.001), and age older than 65 years was an independent predictor of mortality. Conclusions: In this large prospective study, increasing age emerges as a major determinant of the clinical characteristics of IE. Lower rates of surgical treatment and high mortality are the most prominent features of elderly patients with IE. Efforts should be made to prevent health care–associated acquisition and improve outcomes in this major subgroup of patients with IE.
261 citations
••
University of Wrocław1, University of Washington2, University of Social Sciences and Humanities3, Baqiyatallah University of Medical Sciences4, King Saud University5, University of Ghana6, University of Milan7, The Chinese University of Hong Kong8, Pontifical Catholic University of Peru9, Federal University of Rio de Janeiro10, Moscow State University11, Russian State University for the Humanities12, Federal University of Rio Grande do Norte13, Ankara University14, University of Coimbra15, Babeș-Bolyai University16, Universidad Iberoamericana Ciudad de México17, İzmir University of Economics18, Charles University in Prague19, Saint Mary's University20, Akdeniz University21, Cumhuriyet University22, University of Zagreb23, Lviv University24, Federal Neuro Psychiatric Hospital25, University of Belgrade26, Central University of Finance and Economics27, University of Nairobi28, Norwegian University of Science and Technology29, National University of Entre Ríos30, Philadelphia University31, University of Granada32, University of Pécs33, Razi University34, University of Science and Culture35, University of Vienna36, Pontifical Catholic University of Rio de Janeiro37, Makerere University Business School38, Adekunle Ajasin University39, Universiti Utara Malaysia40, University of Nigeria, Nsukka41, University of Tartu42, University of Warwick43, University of Magdalena44, University of Karachi45, University of Constantine the Philosopher46, Dresden University of Technology47, University of Amsterdam48, South-West University "Neofit Rilski"49, Matej Bel University50, Indonesia University of Education51, Rio de Janeiro State University52, Indian Institute of Management Bangalore53, Indian Institute of Technology Guwahati54, Kyung Hee University55
TL;DR: In this paper, an extensive analysis of interpersonal distances over a large data set (N = 8,943 participants from 42 countries) was presented, which attempted to relate the preferred social, personal, and intimate distances observed in each country to a set of individual characteristics of the participants, and some attributes of their cultures.
Abstract: Human spatial behavior has been the focus of hundreds of previous research studies. However, the conclusions and generalizability of previous studies on interpersonal distance preferences were limited by some important methodological and sampling issues. The objective of the present study was to compare preferred interpersonal distances across the world and to overcome the problems observed in previous studies. We present an extensive analysis of interpersonal distances over a large data set (N = 8,943 participants from 42 countries). We attempted to relate the preferred social, personal, and intimate distances observed in each country to a set of individual characteristics of the participants, and some attributes of their cultures. Our study indicates that individual characteristics (age and gender) influence interpersonal space preferences and that some variation in results can be explained by temperature in a given region. We also present objective values of preferred interpersonal distances in different regions, which might be used as a reference data point in future studies.
260 citations
••
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Abstract: Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and finally to death (1). It is well known that lifestyle choices such as smoking and physical activity can hasten or delay the aging process (2). Such observations have led to the search for molecular markers of age that can be used to predict, monitor, and provide insight into age-associated physiological decline and disease.
Protein structure is defined by the sequence of nucleotides in the corresponding genes, thus the polypeptide sequence of a protein cannot change with age. However, an important structural and functional element of the majority of proteins are the glycans that participate in virtually all physiological processes (3). Glycans are product of a complex pathway that involves hundreds of different proteins and are encoded in a complex dynamic network of hundreds of genes (4). Epigenetic regulation of gene expression is expected to affect protein glycosylation and several publications recently reported this effect (5–8). Changes in glycosylation with age have been shown over 20 years ago (9) and have also replicated in recent large population studies (10–13).
Immunoglobulin G (IgG) is an excellent model glycoprotein because its glycosylation has been well defined (Figure 1), and many important functional effects of alternative IgG glycosylation have been described (14). For example, glycosylation acts as a switch between pro- and anti-inflammatory IgG functionality. Most of the IgG molecules are not sialylated and are proinflammatory. Terminal α2,6-sialylation of IgG glycans decreases the ability of IgG to bind to activating FcγRs and promotes recognition by DC-SIGN, which increases expression of inhibitory FcγRIIB and is anti-inflammatory (15). Another fascinating example is the role of core fucose in the modulation of antibody-dependent cellular cytotoxicity: IgG-containing glycans that lack core fucose have 100-fold increased affinity for FcγRIIIA and are therefore much more efficient in activating antibody-dependent cellular cytotoxicity than fucosylated glycoforms of the same molecule (16). On average, 95% of the IgG population is core fucosylated (12); thus, most of the immunoglobulins have a “safety switch,” which prevents them from activating antibody-dependent cellular cytotoxicity. Malfunction of this system appears to be associated with autoimmune diseases as indicated by both pleiotropic effects of genes that associate with IgG glycosylation on different inflammatory and autoimmune diseases, and the observed alterations in IgG glycosylation in systemic lupus erythematous (17) and many inflammatory diseases (18).
Figure 1.
UPLC analysis of immunoglobulin G (IgG) glycosylation. Each IgG contains one conserved N-glycosylation site on Asn197 of its heavy chain. Different glycans can be attached to this site and the process seems to be highly regulated. UPLC analysis can reveal ...
Interindividual variability of IgG glycosylation in a population is large (12) and it appears to be affected by both variation in DNA sequence (19) and environmental factors (11). Most of the studies that investigated glycosylation changes with age were either of limited size or were performed on the total plasma glycome; thus, in addition to changes in glycosylation, the observed differences reflected changes in the concentration of individual plasma proteins. In this study, we focused on glycosylation of IgG and analyzed more than 5,000 individuals from four different European populations to provide definitive data about changes in IgG glycosylation through the lifetime.
260 citations
••
TL;DR: By exploiting Coulomb dissociation of high-energy radioactive beams of the neutron-rich nuclei, their dipole-strength distributions have been measured as mentioned in this paper, and a sizable fraction of ''pygmy'' dipole strength, energetically located below the giant dipole resonance, is observed in all of these nuclei.
Abstract: By exploiting Coulomb dissociation of high-energy radioactive beams of the neutron-rich nuclei $^{129\ensuremath{-}132}\mathrm{Sn}$ and $^{133,134}\mathrm{Sb}$, their dipole-strength distributions have been measured. A sizable fraction of ``pygmy'' dipole strength, energetically located below the giant dipole resonance, is observed in all of these nuclei. A comparison with available pygmy resonance data in stable nuclei ($^{208}\mathrm{Pb}$ and $N=82$ isotones) indicates a trend of strength increasing with the proton-to-neutron asymmetry. On theoretical grounds, employing the RQRPA approach, a one-to-one correlation is found between the pygmy strength and parameters describing the density dependence of the nuclear symmetry energy, and in turn with the thicknesses of the neutron skins. On this basis, by using the experimental pygmy strength, parameters of the nuclear symmetry energy (${a}_{4}=32.0\ifmmode\pm\else\textpm\fi{}1.8$ MeV and ${p}_{o}=2.3\ifmmode\pm\else\textpm\fi{}0.8$ MeV/fm${}^{3}$) are deduced as well as neutron-skin thicknesses ${R}_{n}\ensuremath{-}{R}_{p}$ of $0.24\ifmmode\pm\else\textpm\fi{}0.04$ fm for $^{132}\mathrm{Sn}$ and of $0.18\ifmmode\pm\else\textpm\fi{}0.035$ fm for $^{208}\mathrm{Pb}$, both doubly magic nuclei. Astrophysical implications with regard to neutron stars are briefly addressed.
259 citations
••
Humboldt University of Berlin1, Sapienza University of Rome2, University of Vermont3, European Forest Institute4, University of Freiburg5, Danish Nature Agency6, University of Forestry, Sofia7, University of Turin8, Forest Research Institute9, Mediterranean University10, University of Lisbon11, University of Zagreb12, Czech University of Life Sciences Prague13, Aleksandras Stulginskis University14, University of Trás-os-Montes and Alto Douro15, Saints Cyril and Methodius University of Skopje16, Swiss Federal Institute for Forest, Snow and Landscape Research17, University of Agriculture, Faisalabad18, University of Eastern Finland19, Bulgarian Academy of Sciences20
TL;DR: In this article, Sabatini et al. discuss the importance of gender diversity in soccer and discuss the role of gender in the sport of soccer in terms of sportswriting.
Abstract: Francesco Maria Sabatini1 | Sabina Burrascano2 | William S. Keeton3 | Christian Levers1 | Marcus Lindner4 | Florian Pötzschner1 | Pieter Johannes Verkerk5 | Jürgen Bauhus6 | Erik Buchwald7 | Oleh Chaskovsky8 | Nicolas Debaive9 | Ferenc Horváth10 | Matteo Garbarino11 | Nikolaos Grigoriadis12 | Fabio Lombardi13 | Inês Marques Duarte14 | Peter Meyer15 | Rein Midteng16 | Stjepan Mikac17 | Martin Mikoláš18 | Renzo Motta11 | Gintautas Mozgeris19 | Leónia Nunes14,20 | Momchil Panayotov21 | Peter Ódor10 | Alejandro Ruete22 | Bojan Simovski23 | Jonas Stillhard24 | Miroslav Svoboda18 | Jerzy Szwagrzyk25 | Olli-Pekka Tikkanen26 | Roman Volosyanchuk27 | Tomas Vrska28 | Tzvetan Zlatanov29 | Tobias Kuemmerle1
258 citations
Authors
Showing all 22096 results
Name | H-index | Papers | Citations |
---|---|---|---|
Harry Campbell | 150 | 897 | 115457 |
Joseph R. Ecker | 148 | 381 | 94860 |
Igor Rudan | 142 | 658 | 103659 |
Nikola Godinovic | 138 | 1469 | 100018 |
Ivica Puljak | 134 | 1436 | 97548 |
Damir Lelas | 133 | 1354 | 93354 |
Željko Ivezić | 129 | 344 | 84365 |
Piotr Ponikowski | 120 | 762 | 131682 |
Marin Soljacic | 117 | 764 | 51444 |
Ivan Dikic | 107 | 359 | 52088 |
Ozren Polasek | 102 | 436 | 52674 |
Mordechai Segev | 99 | 729 | 40073 |
Srdan Verstovsek | 96 | 1045 | 38936 |
Segev BenZvi | 95 | 482 | 32127 |
Mirko Planinic | 94 | 467 | 31957 |