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Institution

University of Zagreb

EducationZagreb, Grad Zagreb, Croatia
About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.


Papers
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Journal ArticleDOI
TL;DR: It is evident that glycosylation plays an important role in the inflammatory response and the greatest value of these changes currently lays in their potential diagnostic and prognostic usage, either in combination with current diagnostic markers or on their own.
Abstract: Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins (α1-acid glycoprotein, immunoglobulin G, immunoglobulin A, transferrin, haptoglobin, α2-macroglobulin, C-reactive protein, and others) Molecular background and physiological importance of most of these changes are yet to be discovered, but it is evident that glycosylation plays an important role in the inflammatory response Maybe the greatest value of these changes currently lays in their potential diagnostic and prognostic usage, either in combination with current diagnostic markers or on their own However, determining glycan structures is still technically too complex for most clinical laboratories and further efforts have to be made to develop simple analytical tools to study changes in glycosylation

224 citations

Journal ArticleDOI
TL;DR: In this article, the authors studied the corrosion kinetics of low-carbon steel in hydrochloric acid at various concentrations of mimosa tannin inhibitor and derived the inhibition efficiency, η, from the corrosion current, icorr and charge transfer resistance, Rct data.
Abstract: Corrosion kinetics of low-carbon steel in hydrochloric acid was studied at various concentrations of mimosa tannin inhibitor. This system was subjected to impedance spectroscopy and quasi steady-state polarization. The inhibition efficiency, η was derived from the corrosion current, icorr and charge transfer resistance, Rct data. The fractional surface coverage as a function of the inhibitor concentration was calculated from the rate of hydrogen evolution reaction (h.e.r.) at constant cathodic potential. Based on the theoretical model and the observed experimental relationship between the ratio of the corrosion current densities in the uninhibited and the inhibited systems and the surface coverage, the relative influences of the geometric blocking action and the energy effect of the inhibitor on the corrosion process were estimated. Fitting of the nonlinear model to the experimental data was carried out by the Levnberg–Marquardt nonlinear fit method implemented into the programming system Mathematica®. Restructuring of the adsorbed layer and change in the orientation of adsorbed inhibitor molecules upon the increase of surface coverage was assumed on the basis of the experimentally observed functional relationship of the double layer capacitance and the surface coverage. The results were explained with respect to the molecular properties of the inhibitor – geometry and size of the molecule, electronic orbital structure and dipole moment.

224 citations

Journal ArticleDOI
TL;DR: The regulatory pathway and initiatives endeavoring to ensure the safe and timely clinical translation of emerging nanotherapeutics and realization of health care benefits are discussed, which represent the most successful and commercialized categories within the field of nanomedicine.
Abstract: The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug’s therapeutic index, and reduce a drug’s immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-, virosome-, polymer therapeutic-, nanoemulsion-, and nanoparticle-based approaches to nanotherapeutics, which represent the most successful and commercialized categories within the field of nanomedicine. We discuss the regulatory pathway and initiatives endeavoring to ensure the safe and timely clinical translation of emerging nanotherapeutics and realization of health care benefits. Emerging trends are expected to confirm that this nano-concept can exert a macro-impact on patient benefits, treatment options, and the EU economy.

223 citations

Book ChapterDOI
TL;DR: Evidence is obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients, and it is proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in s AD.
Abstract: A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid beta (Abeta) peptide are the cause of all forms of Alzheimer's disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZ-icv rat model and are associated with tau protein hyperphosphorylation and Abeta-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in sAD.

223 citations

Journal ArticleDOI
TL;DR: In this paper, modified hydrothermal and "wet" precipitation routes at room temperature were employed to synthesize pure monoclinic BiVO 4 powders of varying particle morphologies.

223 citations


Authors

Showing all 22096 results

NameH-indexPapersCitations
Harry Campbell150897115457
Joseph R. Ecker14838194860
Igor Rudan142658103659
Nikola Godinovic1381469100018
Ivica Puljak134143697548
Damir Lelas133135493354
Željko Ivezić12934484365
Piotr Ponikowski120762131682
Marin Soljacic11776451444
Ivan Dikic10735952088
Ozren Polasek10243652674
Mordechai Segev9972940073
Srdan Verstovsek96104538936
Segev BenZvi9548232127
Mirko Planinic9446731957
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023119
2022525
20213,277
20203,360
20193,176
20183,042