University of Zagreb

About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.

A new quark-hadron hybrid equation of state for astrophysics - I. High-mass twin compact stars

Abstract: Aims. We present a new microscopic hadron-quark hybrid equation of state model for astrophysical applications, from which compact hybrid star configurations are constructed. These are compo sed of a quark core and a hadronic shell with first-order phase transition at their interface. The resulting mass-radius relations ar e in accordance with the latest astrophysical constraints. Methods. The quark matter description is based on a QCD motivated chiral approach with higher-order quark interactions in the Dirac scalar and vector coupling channels. For hadronic matter we select a relativistic mean-field equation of state with dens ity-dependent couplings. Since the nucleons are treated in the quasi-part icle framework, an excluded volume correction has been included for the nuclear equation of state at suprasaturation density which takes into account the finite size of the nucleons. Results. These novel aspects, excluded volume in the hadronic phase and the higher-order repulsive interactions in the quark phase, lead to a strong first-order phase transition with large late nt heat, i.e. the energy-density jump at the phase transitio n, which fulfills a criterion for a disconnected third-family branch of compact stars in the mass-radius relationship. These twin stars appear at high masses (∼ 2 M⊙) being relevant for current observations of high-mass pulsars. Conclusions. This analysis offers a unique possibility by radius observations of compact stars to probe the QCD phase diagram at zero temperature and large chemical potential and even to support the existence of a critical point in the QCD phase diagram.

Maximum voluntary molar bite force in subjects with normal occlusion

Abstract: The aims of this investigation were to determine whether stabilization of maximum voluntary bite force (MVBF) occurs between 15 and 18 years of age in subjects with a normal occlusion, and to assess the influence of gender, body mass index (BMI), morphological occlusion, and jaw function measured by the number of occlusal contacts, overjet, overbite, maximal mouth opening, mandibular deflection during opening, sagittal slide between the retruded contact position and the intercuspal position, and number of dental restorations. The sample comprised 60 Caucasian subjects aged 15 (15 males and 15 females) and 18 (14 males and 16 females) years with a neutral occlusion, balanced facial profile, and absence of a previous orthodontic history. Bite force measurements were undertaken using a portable occlusal force gauge on both the left and the right sides of the jaw in the first molar region during maximal clenching. Two independent samples t -tests and multiple regression were used for statistical analysis. MVBFs were age and gender related ( P < 0.05). Males showed a significant increase in bite force between 15 and 18 years of age ( P = 0.002), but gender differences were significant only in the 18-year-olds ( P = 0.003). In subjects with a neutral occlusion, MVBF could best be predicted using multiple regression from age and gender. The regression model accounted for 31.3 per cent of the variance in MVBF ( P = 0.031), with gender contributing 17.9 per cent and age 7.9 per cent. Morphological occlusion, jaw function, and BMI explained the remaining 5.5 per cent of variance. While controlling for all other parameters, the independent contribution of gender to the prediction of MVBF was 16.2 per cent, age 6 per cent, number of occlusal contacts 3.2 per cent, and BMI 1.3 per cent.

European evidence-based (S3) guideline for the treatment of acne – update 2016 – short version

Abstract: European evidence-based (S3) guideline for the treatment of acne – update 2016 – short version A. Nast,* B. Dr eno, V. Bettoli, Z. Bukvic Mokos, K. Degitz, C. Dressler, A.Y. Finlay, M. Haedersdal, J. Lambert, A. Layton, H.B. Lomholt, J.L. L opez-Estebaranz, F. Ochsendorf, C. Oprica, S. Rosumeck, T. Simonart, R.N. Werner, H. Gollnick Division of Evidence-Based Medicine, Klinik f€ ur Dermatologie, Charit e Universit€atsmedizin Berlin, Berlin, Germany Department of Dermatocancerolgy, Nantes University Hospital, Hôtel-Dieu, Nantes, France 3 Department of Clinical and Experimental Medicine, Section of Dermatology, University of Ferrara, Ferrara, Italy Department of Dermatology, School of Medicine University of Zagreb, Zagreb, Croatia 5 Private practice, Munich, Germany Department of Dermatology and Wound Healing, Cardiff University School of Medicine, Cardiff, UK Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark University Hospital of Antwerp, University of Antwerp, Antwerp, Belgium Department of Dermatology, Harrogate and District Foundation Trust, Harrogate, North Yorkshire, UK Aarhus Universitet, Aarhus, Denmark Dermatology Department, Alcorcon University Hospital Foundation, Alcorc on, Madrid, Spain Department of Dermatology and Venereology, University of Frankfurt, Frankfurt, Germany Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge and Diagnostiskt Centrum Hud, Stockholm, Sweden Private practice, Anderlecht, Belgium Department of Dermatology and Venereology, University of Magdeburg, Magdeburg, Germany *Correspondence: A. Nast. E-mail: alexander.nast@charite.de

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans.

Abstract: Protein glycosylation affects nearly all molecular interactions at the cell surface and in the intercellular space. Many of the physiological variations which are part of homeostatic mechanisms influence glycosylation. However, a comprehensive overview of changes in glycosylation caused by aging and common lifestyle parameters is still lacking. After analyzing N-glycans in the plasma of 1914 individuals from the Croatian islands of Vis and Korcula, we performed a comprehensive analysis of the dependence of different glycosylation features (position of fucose, level of galactosylation, sialylation and branching) on aging, smoking, body fat and plasma lipid status. A number of statistically significant associations were observed. Glycosylation changes with aging were especially evident in females, mostly in association with the transition from pre-menopausal to post-menopausal age. Levels of core-fucosylated, non-galactosylated, digalactosylated and disialylated biantennary glycans were shown to be mainly age dependent, but the level of branching and higher levels of galactosylation were found to correlate with lipid status. For the majority of glycans which we analyzed, all examined parameters explained up to 5% of the variance. The only notable exception were non-galactosylated glycans where 20% of the variance was explained mostly by age and blood pressure. In general, only a small fraction of the variability in glycan levels observed in a population was explained by age and other measured parameters, indicating that even in the absence of a genetic template, glycan levels are mostly determined by genetic background and/or specific pathophysiological processes.