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Institution

University of Zambia

EducationLusaka, Lusaka, Zambia
About: University of Zambia is a education organization based out in Lusaka, Lusaka, Zambia. It is known for research contribution in the topics: Population & Health care. The organization has 2593 authors who have published 4402 publications receiving 122411 citations. The organization is also known as: UNZA.


Papers
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Journal ArticleDOI
TL;DR: The Pb concentrations exceeding ML in the fish suggests that Pb may affect the health of fish, and future investigations should include regular monitoring of heavy metals in farmed and wild fish in Tanzania for further development of sustainable aquaculture and the welfare of the wild fish stock in the coastal waters.

41 citations

Journal ArticleDOI
01 Dec 2020
TL;DR: This diagnostic/prognostic study describes the use of cell-free transcriptomics, urine metabolomics, and plasma proteomics for identifying the biological measurements associated with preterm birth.
Abstract: Importance Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection and guide therapeutic studies. Objective To investigate the ability of transcriptomics and proteomics profiling of plasma and metabolomics analysis of urine to identify early biological measurements associated with PTB. Design, setting, and participants This diagnostic/prognostic study analyzed plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in low- and middle-income countries (LMICs; ie, Matlab, Bangladesh; Lusaka, Zambia; Sylhet, Bangladesh; Karachi, Pakistan; and Pemba, Tanzania). These cohorts were established to study maternal and fetal outcomes and were supported by the Alliance for Maternal and Newborn Health Improvement and the Global Alliance to Prevent Prematurity and Stillbirth biorepositories. Data were analyzed from December 2018 to July 2019. Exposures Blood and urine specimens that were collected early during pregnancy (median sampling time of 13.6 weeks of gestation, according to ultrasonography) were processed, stored, and shipped to the laboratories under uniform protocols. Plasma samples were assayed for targeted measurement of proteins and untargeted cell-free ribonucleic acid profiling; urine samples were assayed for metabolites. Main outcomes and measures The PTB phenotype was defined as the delivery of a live infant before completing 37 weeks of gestation. Results Of the 81 pregnant women included in this study, 39 had PTBs (48.1%) and 42 had term pregnancies (51.9%) (mean [SD] age of 24.8 [5.3] years). Univariate analysis demonstrated functional biological differences across the 5 cohorts. A cohort-adjusted machine learning algorithm was applied to each biological data set, and then a higher-level machine learning modeling combined the results into a final integrative model. The integrated model was more accurate, with an area under the receiver operating characteristic curve (AUROC) of 0.83 (95% CI, 0.72-0.91) compared with the models derived for each independent biological modality (transcriptomics AUROC, 0.73 [95% CI, 0.61-0.83]; metabolomics AUROC, 0.59 [95% CI, 0.47-0.72]; and proteomics AUROC, 0.75 [95% CI, 0.64-0.85]). Primary features associated with PTB included an inflammatory module as well as a metabolomic module measured in urine associated with the glutamine and glutamate metabolism and valine, leucine, and isoleucine biosynthesis pathways. Conclusions and relevance This study found that, in LMICs and high PTB settings, major biological adaptations during term pregnancy follow a generalizable model and the predictive accuracy for PTB was augmented by combining various omics data sets, suggesting that PTB is a condition that manifests within multiple biological systems. These data sets, with machine learning partnerships, may be a key step in developing valuable predictive tests and intervention candidates for preventing PTB.

41 citations

Journal ArticleDOI
TL;DR: The two general research areas identified within the sixth element of the WHO recommended Stop TB Strategy as those most important for control of tuberculosis are described below.

41 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated whether a time-series NDVI reference curve library for crops over a growing season for one year could be used to map crops for a different year.
Abstract: The goal of this research was to conduct an initial investigation into whether a time-series NDVI reference curve library for crops over a growing season for one year could be used to map crops for a different year. Time-series NDVI libraries of curves for 2001 and 2005 were investigated to ascertain whether or not the 2001 dataset could be used to map crops for 2005. The 2005 16-day composite MODIS 250 m NDVI data were used to extract NDVI values from 1,615 field sites representing alfalfa, corn, sorghum, soybeans, and winter wheat. A k-means cluster analysis of NDVI values from the field sites was performed to identify validation sites with time-series NDVI spectral profiles characteristic of the major crop types grown in Kansas. After completing the field site refinement process, there were 1,254 field sites retained for further analysis, referred to as "final" field sites. The methods employed to evaluate whether the MODIS-based NDVI profiles for major crops in Kansas are stable from year-to-year invo...

41 citations

Journal ArticleDOI
TL;DR: The human immunodeficiency virus pandemic has contributed to a marked increase in patients infected with tuberculosis in parts of SubSaharan Africa and in patients with osteoarticular tuberculosis who are positive for the virus, the prognosis will depend on the stage that the human immunosuppressive virus infection has reached by the time of presentation.
Abstract: The human immunodeficiency virus pandemic has contributed to a marked increase in patients infected with tuberculosis. In parts of SubSaharan Africa, osteoarticular tuberculosis has increased fourfold in the past decade and approximately 60% of the patients are infected with the human immunodeficien

41 citations


Authors

Showing all 2635 results

NameH-indexPapersCitations
Alimuddin Zumla10074743284
David Clark7365224857
Sten H. Vermund6960622181
Paul A. Kelly6820816836
Francis Drobniewski6729317371
Ayato Takada6727314467
Karl Peltzer6088018515
Hirofumi Sawa5532511735
Peter Godfrey-Faussett521738486
Igor J. Koralnik5219710186
Peter Mwaba481327386
Alison M. Elliott482997772
Kelly Chibale473377713
Chihiro Sugimoto473257737
Sian Floyd471636791
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202318
202248
2021481
2020505
2019358
2018299