University of Zimbabwe

About: University of Zimbabwe is a education organization based out in Harare, Harare, Zimbabwe. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 4378 authors who have published 6800 publications receiving 160720 citations. The organization is also known as: UZ & University College of Rhodesia and Nyasaland.

Serum amyloid A and transferrin in chicken. A preliminary investigation of using acute-phase variables to assess diseases in chickens.

Abstract: Summary The concentrations of serum amyloid A protein (SAA) and transferrin in blood samples from broilers in various stages of natural Staphylococcus aureus infection, from healthy counterparts, and from turpentine‐ or saline‐injected pullets were measured using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS‐PAGE), immunoblotting, and densitometry. SAA was not detected in healthy chickens but was detected in turpentine‐injected pullets and in S. aureus‐infected broilers. Relative percentages of transferrin in turpentine‐ and saline‐injected pullets were not different. Broilers with a S. aureus infection had a two‐fold higher transferrin level than did their unaffected counterparts. There was also a difference between the transferrin levels of healthy broilers and healthy pullets, which indicates that other variables, such as breed or breeding conditions, may influence the transferrin level. This preliminary study showed that SAA is an acute‐phase protein and a more reliable variable for ...

Communication of the musculocutaneous nerve with the median nerve.

Abstract: Objective To study the frequency of occurrence as well as the course and variations in the communicating branch of the musculocutaneous nerve and the relationship of the communicating branch to other structures in the upper arms of Zimbabwean subjects. Design Cross sectional anatomical dissections. Setting Department of Anatomy,University of Zimbabwe Medical School, Harare, Zimbabwe. Subjects Twenty four upper limbs from twelve preserved cadavers of both sexes. Results Eight instances of communication from musculocutaneous nerve to the median nerve were observed. Bilateral communication was observed in two cadavers. The communicating branch arose either before or after it pierced the coracobrachialis muscle. In one instance the whole musculocutaneous nerve joined the median nerve. In two instances, the musculocutaneous nerve did not pierce the coracobrachialis muscle. In two instances the communicating branch arose after the origin of the muscular branch to the biceps brachii. Conclusions The communicating branch was present in 33% of the cases. The communicating branch when present varied considerably in respect of its origin and its union with the median nerve. In one extreme case, the whole musculocutaneous nerve joined the median nerve and the muscular branches to the biceps brachii and brachilis arose from the median nerve. The clinician or surgeon should be aware of the presence of communicating branch and its variations in origin, course and relationships in the upper arm.

'Opening up the mind': Problem-solving therapy delivered by female lay health workers to improve access to evidence-based care for depression and other common mental disorders through the Friendship Bench Project in Zimbabwe

Abstract: There are few accounts of evidence-based interventions for depression and other common mental disorders (CMDs) in primary care in low-income countries. The Friendship Bench Project is a collaborative care mental health intervention in primary care in Harare for CMDs which began as a pilot in 2006. We employed a mixture of quantitative and qualitative approaches to investigate the project’s acceptability and implementation, 4–8 years after the initial pilot study. We carried out basic descriptive analyses of routine data on attendance collected between 2010 and 2014. We also conducted five focus group discussions (FGDs) with LHWs in 2013 and 12 in-depth interviews, six with staff and six with patients, to explore experiences of the intervention, which we analysed using grounded theory. Results show that the intervention appears highly acceptable as evidenced by a consistent number of visits between 2010 and 2014 (mean 505 per year, SD 132); by the finding that the same team of female community LHWs employed as government health promoters continue to deliver assessment and problem-solving therapy, and the perceived positive benefits expressed by those interviewed. Clients described feeling ‘relieved and relaxed’ after therapy, and having their ‘mind opened’, and LHWs describing satisfaction from being agents of change. Characteristics of the LHWs (status in the community, maturity, trustworthiness), and of the intervention (use of locally validated symptom screen, perceived relevance of problem-solving therapy) and continuity of the LHW team appeared crucial. Challenges to implementation included the LHWs ongoing need for weekly supervision despite years of experience; the supervisors need for supervision for herself; training needs in managing suicidal and hostile clients; poor documentation; lack of follow-up of depressed clients; and poor access to antidepressants. This case study shows that a collaborative care intervention for CMDs is positively received by patients, rewarding for LHWs to deliver, and can be sustained over time at low cost. Next steps include evaluation of the impact of the intervention through a randomised trial, and testing of a technological platform for supporting supervision and monitoring clients’ attendance.

Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa.

Abstract: The development of new antibiotics from new chemical entities is becoming more and more expensive, time-consuming, and compounded by emerging strains that are drug resistant. Alkaloids are plant secondary metabolites which have been shown to have potent pharmacological activities. The effect of alkaloids from Callistemon citrinus and Vernonia adoensis leaves on bacterial growth and efflux pump activity was evaluated on Staphylococcus aureus and Pseudomonas aeruginosa. At a concentration of 1.67 mg/mL, the alkaloids inhibited bacterial growth with comparable effects to ampicillin, a standard antibiotic. The alkaloids from C. citrinus were the most potent against S. aureus with an MIC of 0.0025 mg/mL and MBC of 0.835 mg/mL. It was shown that effects on P. aeruginosa by both plant alkaloids were bacteriostatic. P. aeruginosa was most susceptible to drug efflux pump inhibition by C. citrinus alkaloids which caused an accumulation of Rhodamine 6G of 121% compared to the control. Thus, C. citrinus alkaloids showed antibacterial activity as well as inhibiting ATP-dependent transport of compounds across the cell membrane. These alkaloids may serve as potential courses of compounds that can act as lead compounds for the development of plant-based antibacterials and/or their adjunct compounds.