Institution
University of Zimbabwe
Education•Harare, Harare, Zimbabwe•
About: University of Zimbabwe is a education organization based out in Harare, Harare, Zimbabwe. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 4378 authors who have published 6800 publications receiving 160720 citations. The organization is also known as: UZ & University College of Rhodesia and Nyasaland.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), Agriculture, Health care, Public health
Papers published on a yearly basis
Papers
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TL;DR: It is possible to estimate incidence from cross-sectional prevalence data with sufficient accuracy to monitor the HIV epidemic and two methods were developed that decompose observed changes in prevalence between two serosurveys into the contributions of new infections and mortality.
Abstract: Background HIV surveillance of generalised epidemics in Africa primarily relies on prevalence at antenatal clinics, but estimates of incidence in the general population would be more useful. Repeated cross-sectional measures of HIV prevalence are now becoming available for general populations in many countries, and we aim to develop and validate methods that use these data to estimate HIV incidence. Methods and Findings Two methods were developed that decompose observed changes in prevalence between two serosurveys into the contributions of new infections and mortality. Method 1 uses cohort mortality rates, and method 2 uses information on survival after infection. The performance of these two methods was assessed using simulated data from a mathematical model and actual data from three community-based cohort studies in Africa. Comparison with simulated data indicated that these methods can accurately estimates incidence rates and changes in incidence in a variety of epidemic conditions. Method 1 is simple to implement but relies on locally appropriate mortality data, whilst method 2 can make use of the same survival distribution in a wide range of scenarios. The estimates from both methods are within the 95% confidence intervals of almost all actual measurements of HIV incidence in adults and young people, and the patterns of incidence over age are correctly captured.
140 citations
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McMaster University1, University of Missouri–Kansas City2, Stanford University3, University of Massachusetts Medical School4, University of Zimbabwe5, University of Cape Town6, International Agency for Research on Cancer7, University of Washington8, Centers for Disease Control and Prevention9, McGill University10, American Cancer Society11, PATH12, Jhpiego13, Boston Children's Hospital14, World Health Organization15
TL;DR: It is estimated that 1%–2% of women develop cervical intraepithelial neoplasia grade 2–3 annually worldwide, and the prevalence among women living with HIV is higher, at 10%.
139 citations
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TL;DR: Morbidity is extremely high among HIV-infected infants, morbidity is higher among HEU infants and increases with severity of maternal disease, but is significantly higher for all mothers with CD4 cell count <800 cells/&mgr;L.
Abstract: Background:Human immunodeficiency virus (HIV) remains a major cause of pediatric morbidity in Africa In addition, HIV-exposed, but uninfected (HEU) infants can comprise a substantial proportion of all infants born in high prevalence countries and may also be a vulnerable group with special health p
139 citations
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TL;DR: In this article, the authors used R-mode factor analysis to identify a chemical signature (nitrate and phosphate; minor iron) related to the sewage works, but this signature involved parameters that were within regulated limits, the finding was of limited value for management purposes.
Abstract: Although developed as a tool in the social sciences, R-mode factor analysis, a multivariate statistical tool, has proven highly effective in studies of groundwater quality. The technique examines the relationships between variables (such as chemical parameters in groundwater), which are shown by a number of cases (such as sampling points). In this study, two examples are presented. The first is of groundwater around a southern African iron ore mine and the second is of groundwater in the vicinity of a southern African municipal sewage disposal works. Groundwater samples were collected, their chemistry analysed and factor analysis was performed on each of the chemical datasets. In the first case study, factor analysis successfully separated signatures due to uncontaminated groundwater (calcium, magnesium and bicarbonate), agricultural activities (potassium and ammonium) and mining activities (sodium, chloride and sulphate). In the second case study, factor analysis did identify a chemical signature (nitrate and phosphate; minor iron) related to the sewage works—but since this signature involved parameters that were within regulated limits, the finding was of limited value for management purposes. Thus although R-mode factor analysis can be a valuable tool studies of groundwater quality, this is not always the case. Multivariate statistical techniques like factor analysis should thus be used as supplementary to, but not in replacement of, conventional groundwater quality data treatment methods.
139 citations
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TL;DR: A common mechanism for the development of depression, as defined by international criteria, between Zimbabwe and London is indicated and the high frequency of severe events, and their especially adverse qualities, offer an explanation for the high incidence of depression in Harare.
Abstract: Background. A previous paper (Abas & Broadhead, 1997) reported that among 172 women randomly selected from a Zimbabwean township 30‐8% had a depressive or anxiety disorder during the previous year. Compared with London, the higher annual prevalence of disorders in Harare could mostly be accounted for by an excess of onset cases in the study year (annual incidence of depression 18%). This paper reports on the role of life events and diculties in the aetiology of depression among these women. Method. Randomly selected women (N fl 172) from a township in Harare were interviewed with a Zimbabwean modification of the Bedford College Life Events and Diculties Schedule (LEDS). Results. Events and diculties proved critical in provoking the onset of depression in Harare. Far more events occurring in Harare were severe or disruptive. Furthermore, a proportion of the Harare severe events were more threatening than have been described in London. As in London, certain types of severe event were particularly depressogenic, i.e. those involving the woman’s humiliation, her entrapment in an ongoing dicult situation, or bereavement. However, more severe events in Harare involved these specific dimensions. Conclusions. Results indicate a common mechanism for the development of depression, as defined by international criteria, between Zimbabwe and London. The high frequency of severe events, and their especially adverse qualities, oer an explanation for the high incidence of depression in Harare.
139 citations
Authors
Showing all 4433 results
Name | H-index | Papers | Citations |
---|---|---|---|
Didier Raoult | 173 | 3267 | 153016 |
Roy M. Anderson | 116 | 526 | 65549 |
Vikram Patel | 116 | 654 | 59717 |
Richard M. Cowling | 96 | 392 | 30042 |
Ken E. Giller | 92 | 555 | 36374 |
Leif Bertilsson | 87 | 321 | 23933 |
Johan Rockström | 85 | 236 | 57842 |
Alex Aiken | 77 | 295 | 20254 |
Frances M. Cowan | 76 | 456 | 19984 |
Robert J. Biggar | 73 | 231 | 18474 |
Charles A. Thornton | 71 | 182 | 17195 |
David Wilson | 69 | 618 | 18780 |
David Katzenstein | 69 | 280 | 21239 |
Bruce M. Campbell | 67 | 227 | 17616 |
David Sanders | 65 | 492 | 17119 |