University of Zimbabwe

About: University of Zimbabwe is a education organization based out in Harare, Harare, Zimbabwe. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 4378 authors who have published 6800 publications receiving 160720 citations. The organization is also known as: UZ & University College of Rhodesia and Nyasaland.

The urban penalty of COVID-19 lockdowns across the globe: manifestations and lessons for Anglophone sub-Saharan Africa.

Abstract: The paper contributes towards deciphering and decoding the misery of the urban poor in light of the COVID-19 scourge. The paper unpacks urban poverty in light of the corona virus. The emergence of the COVID-19 and the lack of any vaccines requires physical distancing as preventative measures to contain and reduce the spread of the virus. Governments across the world, including in Anglophone Sub Saharan Africa have implemented lockdown measures. The COVID-19 pandemic is happening within settlements where the majority of the population lives from hand to mouth. In Anglophone sub-Saharan Africa because of urbanisation and increased urban poverty, COVID-19 scourge has had a huge impact on the urban poor. The COVID-19 is likely to devastate economies and the community. For rapidly growing, densely populated and poorly planned settlements, the situation is tragic for these inhabitants. Nation states lockdown and social and physical distancing in response to the pandemic have escalated their misery. The paper adopts a critical review of literature anchored in case study analysis, document analysis and scanning from reports. Results point to redefining the way humanity has related, functioned and conceptualised realities. There is need to go beyond prevention from infection as majority of urban dwellers are in the informal sector or unemployed. For the urban poor, strategies for social distancing may not be possible or effective. People are being asked to make choices between being hungry and risk of getting infected. The paper recommends planning response at national, regional and local level bearing in mind informal settlements, high densities and forms of overcrowding which have been placed as hotspots for the virus. There is need for rebuilding societies, during and beyond COVID-19 calling for immediate disaster risk planning adaptation and transformation to promote resilience.

A scoping review of interventions for crop postharvest loss reduction in sub-Saharan Africa and South Asia

Abstract: Reducing postharvest losses (PHLs) of food crops is a critical component of sustainably increasing agricultural productivity. Many PHL reduction interventions have been tested, but synthesized information to support evidence-based investments and policy is scarce. In this study, PHL reduction interventions for 22 crops across 57 countries in sub-Saharan Africa and South Asia from the 1970s to 2019 were systematically reviewed. Screening of the 12,907 studies identified resulted in a collection of 334 studies, which were used to synthesize the evidence and construct an online open-access database, searchable by crop, country, postharvest activity and intervention type. Storage technology interventions mainly targeting farmers dominated (83% of the studies). Maize was the most studied crop (25%). India had the most studies (32%), while 25 countries had no studies. This analysis indicates an urgent need for a systematic assessment of interventions across the entire value chain over multiple seasons and sites, targeting stakeholders beyond farmers. The lack of studies on training, finance, infrastructure, policy and market interventions highlights the need for interventions beyond technologies or handling practice changes. Additionally, more studies are needed connecting the impact of PHL reductions to social, economic and environmental outcomes related to Sustainable Development Goals. This analysis provides decision makers with data for informed policy formulation and prioritization of investments in PHL reduction. Reducing postharvest crop losses is vital to sustainably increase agricultural productivity. This analysis reveals a need for systematic assessment of postharvest loss reduction interventions across the value chain, targeting stakeholders beyond farmers, and for a more diverse range of food crops, to shape future policy decisions.

Local therapy of cancer with free IL-2

Abstract: This is a position paper about the therapeutic effects of locally applied free IL-2 in the treatment of cancer. Local therapy: IL-2 therapy of cancer was originally introduced as a systemic therapy. This therapy led to about 20% objective responses. Systemic therapy however was very toxic due to the vascular leakage syndrome. Nevertheless, this treatment was a break-through in cancer immunotherapy and stimulated some interesting questions: Supposing that the mechanism of IL-2 treatment is both proliferation and tumoricidal activity of the tumor infiltrating cells, then locally applied IL-2 should result in a much higher local IL-2 concentration than systemic IL-2 application. Consequently a greater beneficial effect could be expected after local IL-2 application (peritumoral = juxtatumoral, intratumoral, intra-arterial, intracavitary, or intratracheal = inhalation). Free IL-2: Many groups have tried to prepare a more effective IL-2 formulation than free IL-2. Examples are slow release systems, insertion of the IL-2 gene into a tumor cell causing prolonged IL-2 release. However, logistically free IL-2 is much easier to apply; hence we concentrated in this review and in most of our experiments on the use of free IL-2. Local therapy with free IL-2 may be effective against transplanted tumors in experimental animals, and against various spontaneous carcinomas, sarcomas, and melanoma in veterinary and human cancer patients. It may induce rejection of very large, metastasized tumor loads, for instance advanced clinical tumors. The effects of even a single IL-2 application may be impressive. Not each tumor or tumor type is sensitive to local IL-2 application. For instance transplanted EL4 lymphoma or TLX9 lymphoma were not sensitive in our hands. Also the extent of sensitivity differs: In Bovine Ocular Squamous Cell Carcinoma (BOSCC) often a complete regression is obtained, whereas with the Bovine Vulval Papilloma and Carcinoma Complex (BVPCC) mainly stable disease is attained. Analysis of the results of local IL-2 therapy in 288 cases of cancer in human patients shows that there were 27% Complete Regressions (CR), 23% Partial Regressions (PR), 18% Stable Disease (SD), and 32% Progressive Disease (PD). In all tumors analyzed, local IL-2 therapy was more effective than systemic IL-2 treatment. Intratumoral IL-2 applications are more effective than peritumoral application or application at a distant site. Tumor regression induced by intratumoral IL-2 application may be a fast process (requiring about a week) in the case of a highly vascular tumor since IL-2 induces vascular leakage/edema and consequently massive tumor necrosis. The latter then stimulates an immune response. In less vascular tumors or less vascular tumor sites, regression may require 9–20 months; this regression is mainly caused by a cytotoxic leukocyte reaction. Hence the disadvantageous vascular leakage syndrome complicating systemic treatment is however advantageous in local treatment, since local edema may initiate tumor necrosis. Thus the therapeutic effect of local IL-2 treatment is not primarily based on tumor immunity, but tumor immunity seems to be useful as a secondary component of the IL-2 induced local processes. If local IL-2 is combined with surgery, radiotherapy or local chemotherapy the therapeutic effect is usually greater than with either therapy alone. Hence local free IL-2 application can be recommended as an addition to standard treatment protocols. Local treatment with free IL-2 is straightforward and can readily be applied even during surgical interventions. Local IL-2 treatment is usually without serious side effects and besides minor complaints it is generally well supported. Only small quantities of IL-2 are required. Hence the therapy is relatively cheap. A single IL-2 application of 4.5 million U IL-2 costs about 70 Euros. Thus combined local treatment may offer an alternative in those circumstances when more expensive forms of treatment are not available, for instance in resource poor countries.

Cumulative effects of sewage sludge and effluent mixture application on soil properties of a sandy soil under a mixture of star and kikuyu grasses in Zimbabwe

Abstract: Although sewage effluent and sludge provides nutrients for plant growth, its continual use over extended periods can result in the accumulation of heavy metals in soils and in grass to levels that are detrimental to the food chain. This study was carried in 2001 out at Firle farm, owned by the Municipality of Harare, to assess heavy metal loading on a sandy soil and uptake of the metals by pasture grass consisting of a mixture of Cynodon nlemfuensis (star grass) and Pennisetum clandestinum Chiov (kikuyu grass) following sewage effluent and sludge application for 29 years. Firle Farm receives treated effluent and sludge emanating from domestic and industrial sources. Soil and grass samples were taken from the study area, consisting of 3 ha of non-irrigated area (control) and 1.3 ha of irrigated area. Both the soil and grass samples were tested for Cu, Zn, Ni and Pb using atomic absorption spectrophotometry. Sewage sludge addition resulted in high levels of soil pollution, especially in the 20 cm horizon, in the irrigated area when compared to the control. Grasses took up moderate levels of Cu and Zn, and limited levels of Pb. Nickel was not detectable in grasses despite high levels in the irrigated soil. Copper uptake was several times higher than the suggested potentially toxic level of 12 mg/kg [Soil Science Society of America, Micronutrients in agriculture, second ed., Wisconsin, USA, 1991]. Lead uptake averaged 1.0 mg/kg, which was below 10 mg/kg the suggested limit for agronomic crops [E.M. Seaker, Zinc, copper, cadmium and lead in minespoil, water and plants from reclaimed mine land amended with sewage sludge, 1991]. Cu and Zn showed relatively higher mobility down the soil profile than Ni and Pb. Even then, the concentrations in the lower soil layers were very small, suggesting that the metals were unlikely to contaminate groundwater. There was no direct correlation between metal levels in soils and grasses. It was postulated that it is the bio-available metal fraction in the soil that is correlated to plant uptake. The grasses appeared healthy even though they contained moderately high levels of Zn and Cu. This raises the possibility of beef animals grazing on “healthy” looking grass that has very high concentrations of heavy metals. The fact that the total metal concentrations in the experimental soil were very high but did not cause any toxicity symptoms to the grass suggested that the limit soil concentration do not necessarily imply toxicity to all plants. However, limit concentrations are set not only for plant growth, but also for the protection of soil microorganisms and the latter are more sensitive to heavy metal pollution.