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Institution

University of Zurich

EducationZurich, Switzerland
About: University of Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Transplantation. The organization has 50842 authors who have published 124042 publications receiving 5304521 citations. The organization is also known as: UZH & Uni Zurich.


Papers
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Journal ArticleDOI
TL;DR: This document presents an updated version of the guideline for the management of bleeding following severe injury, which provides an evidence-based multidisciplinary approach to themanagement of critically injured bleeding trauma patients.
Abstract: Introduction: Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes. Methods: The multidisciplinary Task Force for Advanced Bleeding Care in Trauma was formed in 2005 with the aim of developing a guideline for the management of bleeding following severe injury. This document presents an updated version of the guideline published by the group in 2007. Recommendations were formulated using a nominal group process, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) hierarchy of evidence and based on a systematic review of published literature. Results: Key changes encompassed in this version of the guideline include new recommendations on coagulation support and monitoring and the appropriate use of local haemostatic measures, tourniquets, calcium and desmopressin in the bleeding trauma patient. The remaining recommendations have been reevaluated and graded based on literature published since the last edition of the guideline. Consideration was also given to changes in clinical practice that have taken place during this time period as a result of both new evidence and changes in the general availability of relevant agents and technologies. Conclusions: This guideline provides an evidence-based multidisciplinary approach to the management of critically injured bleeding trauma patients.

727 citations

Journal ArticleDOI
Tomoatsu Ikeya1, Milos Galic1, Priyanka Belawat1, Knud Nairz1, Ernst Hafen1 
TL;DR: A causal link between nutrient availability and insulin-dependent growth is established and results point to a conserved role of the neuroendocrine axis in growth control in multicellular organisms.

726 citations

Journal ArticleDOI
TL;DR: This paper shows conversion of popular CNN architectures, including VGG-16 and Inception-v3, into SNNs that produce the best results reported to date on MNIST, CIFAR-10 and the challenging ImageNet dataset.
Abstract: Spiking neural networks (SNNs) can potentially offer an efficient way of doing inference because the neurons in the networks are sparsely activated and computations are event-driven. Previous work showed that simple continuous-valued deep Convolutional Neural Networks (CNNs) can be converted into accurate spiking equivalents. These networks did not include certain common operations such as max-pooling, softmax, batch-normalization and Inception-modules. This paper presents spiking equivalents of these operations therefore allowing conversion of nearly arbitrary CNN architectures. We show conversion of popular CNN architectures, including VGG-16 and Inception-v3, into SNNs that produce the best results reported to date on MNIST, CIFAR-10 and the challenging ImageNet dataset. SNNs can trade off classification error rate against the number of available operations whereas deep continuous-valued neural networks require a fixed number of operations to achieve their classification error rate. From the examples of LeNet for MNIST and BinaryNet for CIFAR-10, we show that with an increase in error rate of a few percentage points, the SNNs can achieve more than 2x reductions in operations compared to the original CNNs. This highlights the potential of SNNs in particular when deployed on power-efficient neuromorphic spiking neuron chips, for use in embedded applications.

725 citations

Journal ArticleDOI
TL;DR: In this paper, a quantum field theory interpretation of Kontsevich's deformation quantization formula for Poisson manifolds is given by the perturbative expansion of the path integral of a simple topological bosonic open string theory.
Abstract: We give a quantum field theory interpretation of Kontsevich's deformation quantization formula for Poisson manifolds. We show that it is given by the perturbative expansion of the path integral of a simple topological bosonic open string theory. Its Batalin–Vilkovisky quantization yields a superconformal field theory. The associativity of the star product, and more generally the formality conjecture can then be understood by field theory methods. As an application, we compute the center of the deformed algebra in terms of the center of the Poisson algebra.

724 citations

Journal ArticleDOI
TL;DR: This article showed that glacier shrinkage is most pronounced in peripheral, lower-elevation ranges near the densely populated forelands, where snow and glacial meltwater is essential for water availability.
Abstract: Climate-driven changes in glacier-fed streamflow regimes have direct implications on freshwater supply, irrigation and hydropower potential. Reliable information about current and future glaciation and runoff is crucial for water allocation, a complex task in Central Asia, where the collapse of the Soviet Union has transformed previously interdependent republics into autonomous upstream and downstream countries. Although the impacts of climate change on glaciation and runoff have been addressed in previous work undertaken in the Tien Shan (known as the ‘water tower of Central Asia’), a coherent, regional perspective of these findings has not been presented until now. Here we show that glacier shrinkage is most pronounced in peripheral, lower-elevation ranges near the densely populated forelands, where summers are dry and where snow and glacial meltwater is essential for water availability. Shifts of seasonal runoff maxima have already been observed in some rivers, and it is suggested that summer runoff will further decrease in these rivers if precipitation and discharge from thawing permafrost bodies do not compensate sufficiently for water shortfalls.

723 citations


Authors

Showing all 51384 results

NameH-indexPapersCitations
Richard A. Flavell2311328205119
Peer Bork206697245427
Thomas C. Südhof191653118007
Stuart H. Orkin186715112182
Ruedi Aebersold182879141881
Tadamitsu Kishimoto1811067130860
Stanley B. Prusiner16874597528
Yang Yang1642704144071
Tomas Hökfelt158103395979
Dan R. Littman157426107164
Hans Lassmann15572479933
Matthias Egger152901184176
Lorenzo Bianchini1521516106970
Robert M. Strieter15161273040
Ashok Kumar1515654164086
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023265
20221,039
20218,997
20208,398
20197,336
20186,832