Institution
University of Zurich
Education•Zurich, Switzerland•
About: University of Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Transplantation. The organization has 50842 authors who have published 124042 publications receiving 5304521 citations. The organization is also known as: UZH & Uni Zurich.
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TL;DR: As inflammation in AD primarily concerns the innate immune system — unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides — the concept of neuroinflammation in AD may need refinement.
Abstract: The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement.
1,523 citations
Journal Article•
Lawrence Berkeley National Laboratory1, University of Zurich2, Stanford University3, College of William & Mary4, University of Genoa5, University of Urbino6, CERN7, Budker Institute of Nuclear Physics8, Cornell University9, Argonne National Laboratory10, ETH Zurich11, Tata Institute of Fundamental Research12, Hillsdale College13, Spanish National Research Council14, Tohoku University15, Ohio State University16, University of California, San Diego17, University of California, Berkeley18, Aix-Marseille University19, University of Minnesota20, University of Alabama21, University of Helsinki22, California Institute of Technology23, George Washington University24, University of Kansas25, RWTH Aachen University26, Boston University27, University of California, Los Angeles28, Institut des Hautes Études Scientifiques29, University of Pennsylvania30, University of Tokyo31, University of Delaware32, Fermilab33, Carnegie Mellon University34, University of California, Santa Cruz35, Lawrence Livermore National Laboratory36, University of Washington37, Karlsruhe Institute of Technology38, Heidelberg University39, Florida State University40, Carleton University41, National Science Foundation42, University of Mainz43, University of Edinburgh44, University of Chicago45, Brookhaven National Laboratory46, Kent State University47, Paul Scherrer Institute48, Max Planck Society49, Massachusetts Institute of Technology50, Nagoya University51, Harvard University52
TL;DR: In this article, a biennial review summarizes much of particle physics using data from previous editions., plus 2778 new measurements from 645 papers, including measurements of gauge bosons, leptons, quarks, mesons, and baryons.
Abstract: This biennial Review summarizes much of particle physics. Using data from previous editions., plus 2778 new measurements from 645 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors., probability, and statistics. Among the 108 reviews are many that are new or heavily revised including those on CKM quark-mixing matrix, V-ud & V-us, V-cb & V-ub, top quark, muon anomalous magnetic moment, extra dimensions, particle detectors, cosmic background radiation, dark matter, cosmological parameters, and big bang cosmology.
1,520 citations
Valentina Escott-Price1, Céline Bellenguez2, Li-San Wang3, Seung Hoan Choi4 +191 more•Institutions (67)
TL;DR: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimers disease.
Abstract: Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This s ...
1,518 citations
TL;DR: In this paper, the authors proposed a revised nomenclature for allergic and related reactions that can be used independently of target organ or patient age group, based on the present knowledge of the mechanisms which initiate and mediate allergic reactions.
Abstract: This report has been prepared by an EAACI task force representing the five EAACI Sections and the EAACI Executive Committee composed of specialists that reflect the broad opinion on allergy expressed by various clinical and basic specialties dealing with allergy. The aim of this report is to propose a revised nomenclature for allergic and related reactions that can be used independently of target organ or patient age group. The nomenclature is based on the present knowledge of the mechanisms which initiate and mediate allergic reactions. However, the intention has not been to revise the nomenclature of nonallergic hypersensitivity.
1,514 citations
TL;DR: A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein.
1,514 citations
Authors
Showing all 51384 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard A. Flavell | 231 | 1328 | 205119 |
| Peer Bork | 206 | 697 | 245427 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Ruedi Aebersold | 182 | 879 | 141881 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Stanley B. Prusiner | 168 | 745 | 97528 |
| Yang Yang | 164 | 2704 | 144071 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Dan R. Littman | 157 | 426 | 107164 |
| Hans Lassmann | 155 | 724 | 79933 |
| Matthias Egger | 152 | 901 | 184176 |
| Lorenzo Bianchini | 152 | 1516 | 106970 |
| Robert M. Strieter | 151 | 612 | 73040 |
| Ashok Kumar | 151 | 5654 | 164086 |