Institution
Uppsala University
Education•Uppsala, Sweden•
About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Insulin. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.
Topics: Population, Insulin, Thin film, Poison control, Gene
Papers published on a yearly basis
Papers
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TL;DR: High-throughput sequencing technologies are revolutionizing the life sciences, and the past 12 months have seen a burst of genome sequences from non-model organisms, in each case representing a fundamental source of data of significant importance to biological research.
Abstract: High-throughput sequencing technologies are revolutionizing the life sciences. The past 12 months have seen a burst of genome sequences from non-model organisms, in each case representing a fundamental source of data of significant importance to biological research. This has bearing on several aspects of evolutionary biology, and we are now beginning to see patterns emerging from these studies. These include significant heterogeneity in the rate of recombination that affects adaptive evolution and base composition, the role of population size in adaptive evolution, and the importance of expansion of gene families in lineage-specific adaptation. Moreover, resequencing of population samples (population genomics) has enabled the identification of the genetic basis of critical phenotypes and cast light on the landscape of genomic divergence during speciation.
607 citations
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TL;DR: The use of N‐terminal pro‐brain natriuretic peptide appears to add critical prognostic insight to the assessment of patients with ACS, and the combination of NT‐proBNP and creatinine clearance provided the best prediction.
Abstract: BACKGROUND: Biochemical markers are useful for prediction of cardiac events in patients with non-ST-segment-elevation acute coronary syndrome (ACS). The associations between N-terminal pro-brain na ...
605 citations
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TL;DR: Hormonal stimulation appears important for the development of radiation-induced breast cancer, as evidenced by the reduced risk associated with ovarian damage from alkylating agents or radiation.
Abstract: ContextSecond cancer is the leading cause of death in long-term survivors of
Hodgkin disease (HD), with exceptionally high risks of breast cancer among
women treated at a young age. Quantitative associations between radiotherapy
dose delivered to the breast and administered chemotherapy have not been reported
to date in large series, nor has the influence of ovarian exposures on subsequent
risk.ObjectiveTo quantify the long-term risk of breast cancer associated with use
of radiotherapy and chemotherapy to treat young women with HD.Design, Setting, and SubjectsMatched case-control study of breast cancer within a cohort of 3817
female 1-year survivors of HD diagnosed at age 30 years or younger, between
January 1, 1965, and December 31, 1994, and within 6 population-based cancer
registries. The study was conducted March 1, 1996, through September 30, 1998.Main Outcome MeasuresRelative risk (RR) of breast cancer associated with radiation dose delivered
to site of breast cancer or to ovaries and with cumulative dose of alkylating
agents.ResultsBreast cancer occurred in 105 patients with HD who were matched to 266
patients with HD but without breast cancer. A radiation dose of 4 Gy or more
delivered to the breast was associated with a 3.2-fold (95% confidence interval
[CI], 1.4-8.2) increased risk, compared with the risk in patients who received
lower doses and no alkylating agents. Risk increased to 8-fold (95% CI, 2.6-26.4)
with a dose of more than 40 Gy (P<.001 for trend).
Radiation risk did not vary appreciably by age at exposure or reproductive
history. Increased risks persisted for 25 or more years following radiotherapy
(RR, 2.3; 95% CI, 0.5-16.5; P = .03 for trend with
dose). Treatment with alkylating agents alone resulted in a reduced risk (RR,
0.6; 95% CI, 0.2-2.0) of breast cancer, and combined alkylating agents and
radiotherapy in a 1.4-fold (95% CI, 0.6-3.5) increased risk. Risk of breast
cancer decreased with increasing number of alkylating agent cycles (P = .003 for trend). Risk also was low (RR, 0.4; 95% CI,
0.1-1.1) among women who received 5 Gy or more delivered to ovaries compared
with those who received lower doses.ConclusionsHormonal stimulation appears important for the development of radiation-induced
breast cancer, as evidenced by the reduced risk associated with ovarian damage
from alkylating agents or radiation. The high radiation-related risk, which
did not diminish at the highest doses or the longest follow-up, however, suggests
the need for lifetime surveillance and programs of patient and public awareness.
605 citations
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TL;DR: In this paper, the authors discuss the importance of hydropower reservoirs and their role in the formation of the world's largest reservoir network, covering an area of 3.4 x 10.5 km(2) and comprising about 20% of all reservoirs.
Abstract: Hydroelectric reservoirs cover an area of 3.4 x 10(5) km(2) and comprise about 20% of all reservoirs. In addition, they contain large stores of formerly terrestrial organic carbon. Significant amou ...
605 citations
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TL;DR: Analysis of patterns of animal dispersal, vicariance and diversification in the Holarctic based on complete phylogenies of 57 extant non-marine taxa shows that trans-Atlantic distributions were common in the Early–Mid Tertiary whereas transBeringian distributions were rare in that period.
Abstract: We analysed patterns of animal dispersal, vicariance and diversification in the Holarctic based on complete phylogenies of 57 extant non-marine taxa, together comprising 770 species, documenting biogeographic events from the Late Mesozoic to the present. Four major areas, each corresponding to a historically persistent landmass, were used in the analyses: eastern Nearctic (EN), western Nearctic (WN), eastern Palaeoarctic (EP) and western Palaeoarctic (WP). Parsimony-based tree fitting showed that there is no significantly supported general area cladogram for the dataset. Yet, distributions are strongly phylogenetically conserved, as revealed by dispersalvicariance analysis (DIVA). DIVA-based permutation tests were used to pinpoint phylogenetically determined biogeographic patterns. Consistent with expectations, continental dispersals (WP↔EP and WN↔EN) are significantly more common than palaeocontinental dispersals (WN↔EP and EN↔WP), which in turn are more common than disjunct dispersals (EN↔EP and WN↔WP). There is significant dispersal asymmetry both within the Nearctic (WN→EN more common than EN→WN) and the Palaeoarctic (EP→WP more common than WP→EP). CrossBeringian faunal connections have traditionally been emphasized but are not more important than cross-Atlantic connections in our data set. To analyse changes over time, we sorted biogeographic events into four major time periods using fossil, biogeographic and molecular evidence combined with a ‘branching clock’. These analyses show that trans-Atlantic distributions (EN–WP) were common in the Early–Mid Tertiary (70–20 Myr), whereas transBeringian distributions (WN–EP) were rare in that period. Most EN–EP disjunctions date back to the Early Tertiary (70–45 Myr), suggesting that they resulted from division of cross-Atlantic rather than cross-Beringian distributions. Diversification in WN and WP increased in the Quaternary (< 3 Myr), whereas in EP and EN it decreased from a maximum in the Early–Mid Tertiary. 2001 The Linnean Society of London
603 citations
Authors
Showing all 36854 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zhong Lin Wang | 245 | 2529 | 259003 |
Lewis C. Cantley | 196 | 748 | 169037 |
Darien Wood | 160 | 2174 | 136596 |
Kaj Blennow | 160 | 1845 | 116237 |
Christopher J. O'Donnell | 159 | 869 | 126278 |
Tomas Hökfelt | 158 | 1033 | 95979 |
Peter G. Schultz | 156 | 893 | 89716 |
Frederik Barkhof | 154 | 1449 | 104982 |
Deepak L. Bhatt | 149 | 1973 | 114652 |
Svante Pääbo | 147 | 407 | 84489 |
Jan-Åke Gustafsson | 147 | 1058 | 98804 |
Hans-Olov Adami | 145 | 908 | 83473 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Kjell Fuxe | 142 | 1479 | 89846 |
Jan Conrad | 141 | 826 | 71445 |