Institution
Uppsala University
Education•Uppsala, Sweden•
About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Insulin. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.
Topics: Population, Insulin, Thin film, Poison control, Gene
Papers published on a yearly basis
Papers
More filters
TL;DR: In this paper, the advantages of the propagator formalism, as a direct method of calculating ionization energies, are stressed for closed-shell systems using an operator method instead of the usual diagrammatic derivations.
Abstract: The advantages of the propagator formalism, as a direct method of calculating ionization energies, are stressed. The propagator equations are derived for closed-shell systems using an operator method instead of the usual diagrammatic derivations. The equations enable the development of an interpretation of the ionization energies in terms of conceptually simple quantities, such as pair correlation energies and associated relaxation effects, and retain the idea of orbital ionization. Infinite summations appearing in the self-energy terms are replaced by finite expressions involving functions satisfying uncoupled inhomogeneous differential equations. Certain high-order propagator equations are derived, and a connection with the Bethe-Goldstone formulation of pair correlation is made. Several computational procedures are advocated as forming the basis for balanced calculations of atomic and molecular ionization energies.
479 citations
TL;DR: A structural explanation for the high stereoselectivity of CALB toward many secondary alcohols is provided and the tetrahedral intermediates of two chiral substrates have been modeled on the basis of available structural and biochemical information.
Abstract: Many lipases are potent catalysts of stereoselective reactions and are therefore of interest for use in chemical synthesis. The crystal structures of lipases show a large variation in the shapes of their active site environments that may explain the large variation in substrate specificity of these enzymes. We have determined the three-dimensional structure of Candida antarctica lipase B (CALB) cocrystallized with the detergent Tween 80. In another crystal form, the structure of the enzyme in complex with a covalently bound phosphonate inhibitor has been determined. In both structures, the active site is exposed to the external solvent. The potential lid-forming helix alpha 5 in CALB is well-ordered in the Tween 80 structure and disordered in the inhibitor complex. The tetrahedral intermediates of two chiral substrates have been modeled on the basis of available structural and biochemical information. The results of this study provide a structural explanation for the high stereoselectivity of CALB toward many secondary alcohols.
479 citations
University of Pennsylvania1, Autonomous University of Barcelona2, Mayo Clinic3, University of Manchester4, Erasmus University Rotterdam5, VU University Amsterdam6, Indiana University – Purdue University Indianapolis7, University of Siena8, National Institutes of Health9, Neuroscience Research Australia10, University of Cambridge11, University of Michigan12, Oregon Health & Science University13, Northwestern University14, King's College London15, University of Texas at Dallas16, University of Texas Southwestern Medical Center17, University of Barcelona18, University of Zurich19, Ludwig Maximilian University of Munich20, Duke University21, University of California, San Francisco22, Boston University23, Veterans Health Administration24, Emory University25, University College London26, University of British Columbia27, University of Pittsburgh28, University of Virginia29, University of Antwerp30, Flanders Institute for Biotechnology31, Columbia University32, Johns Hopkins University33, University of Sydney34, University of New South Wales35, University of Washington36, University of Sheffield37, Washington University in St. Louis38, Alfred Hospital39, University of California, Davis40, Harvard University41, Icahn School of Medicine at Mount Sinai42, Rush University Medical Center43, University of Arizona44, University of California, Los Angeles45, University of Southern California46, Uppsala University47, University of Eastern Finland48, Pierre-and-Marie-Curie University49, University of California, San Diego50, University of California, Irvine51, University of Toronto52, University of Alabama at Birmingham53, University of Würzburg54, Karolinska Institutet55
TL;DR: It is found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM 106B, which implicate variants in TMEM106B as a strong risk factor for FTLD, suggesting an underlying pathogenic mechanism.
Abstract: Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). FTLD-TDP is frequently familial, resulting from mutations in GRN (which encodes progranulin). We assembled an international collaboration to identify susceptibility loci for FTLD-TDP through a genome-wide association study of 515 individuals with FTLD-TDP. We found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM106B. Three SNPs retained genome-wide significance following Bonferroni correction (top SNP rs1990622, P = 1.08 x 10(-11); odds ratio, minor allele (C) 0.61, 95% CI 0.53-0.71). The association replicated in 89 FTLD-TDP cases (rs1990622; P = 2 x 10(-4)). TMEM106B variants may confer risk of FTLD-TDP by increasing TMEM106B expression. TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism.
479 citations
TL;DR: The methodology is sufficiently robust to measure and compare pressure ulcer prevalence in different countries and indicates that more attention to prevention is needed in Europe.
Abstract: Rationale and aims Numerous prevalence studies have been conducted. The problem with these studies is that prevalence proportions cannot be compared with each other, because of differences in performance of each survey. There is no agreed standardized method for determining prevalence proportions. This study aimed to develop and pilot a uniform data collection instrument and methodology to measure the pressure ulcer prevalence and to get some insight into pressure ulcer prevalence across different patient groups in Europe.
Methods Pressure ulcer experts from different European countries developed a data collection instrument, which included five categories of data: general data, patient data, risk assessment, skin observation and prevention. A convenience sample of university and general hospitals of Belgium, Italy, Portugal, UK and Sweden participated in the study. In each participating hospital, teams of two trained nurses who collected the data on the wards were established. All patients admitted before midnight on the day of the survey and older than 18 years were included.
Results The data collection instrument and study procedure of the survey were found to be effective by all participants. 5947 patients were surveyed in 25 hospitals in five European countries. The pressure ulcer prevalence (grade 1–4) was 18.1% and if grade 1 ulcers were excluded, it was 10.5%. The sacrum and heels were the most affected locations. Only 9.7% of the patients in need of prevention received fully adequate preventive care.
Conclusion The methodology is sufficiently robust to measure and compare pressure ulcer prevalence in different countries. The pressure ulcer prevalence was higher than expected and relatively few patients received adequate prevention. This indicates that more attention to prevention is needed in Europe.
478 citations
TL;DR: A diet characterized by low-GI starchy foods lowers the glucose and insulin responses throughout the day and improves the lipid profile and capacity for fibrinolysis, suggesting a therapeutic potential in diabetes.
Abstract: OBJECTIVE: To evaluate the effects of varying the glycemic index (GI) of carbohydrate-rich foods on metabolic control in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: In a randomized crossover study, 20 patients, 5 women and 15 men, were given preweighed diets with different GIs during two consecutive 24-day periods. Both diets were composed in accordance with dietary recommendations for people with diabetes. The macronutrient composition and type and amount of dietary fiber were identical. Differences in GI were achieved mainly by altering the structure of the starchy foods. RESULTS: Peripheral insulin sensitivity increased significantly and fasting plasma glucose decreased during both treatment periods. There was a significant difference in the changes of serum fructosamine concentrations between the diets (P
478 citations
Authors
Showing all 36854 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Zhong Lin Wang | 245 | 2529 | 259003 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Darien Wood | 160 | 2174 | 136596 |
| Kaj Blennow | 160 | 1845 | 116237 |
| Christopher J. O'Donnell | 159 | 869 | 126278 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Peter G. Schultz | 156 | 893 | 89716 |
| Frederik Barkhof | 154 | 1449 | 104982 |
| Deepak L. Bhatt | 149 | 1973 | 114652 |
| Svante Pääbo | 147 | 407 | 84489 |
| Jan-Åke Gustafsson | 147 | 1058 | 98804 |
| Hans-Olov Adami | 145 | 908 | 83473 |
| Hermann Kolanoski | 145 | 1279 | 96152 |
| Kjell Fuxe | 142 | 1479 | 89846 |
| Jan Conrad | 141 | 826 | 71445 |