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Institution

Uppsala University

EducationUppsala, Sweden
About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Insulin. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.
Topics: Population, Insulin, Thin film, Poison control, Gene


Papers
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Journal ArticleDOI
TL;DR: It is shown that there is little floristic variation without any trend in the distribution of plant species in a 2.5 m2 plot of grazed, species- rich Veronica spicata - Avenula pratensis grassland on shal- low, dry, nutrient-poor soil in the Great Alvar area of southern Oland, southeastern Sweden.
Abstract: This study reports on small-scale changes in the distribution of plant species in a 2.5 m2 plot of grazed, species- rich Veronica spicata - Avenula pratensis grassland on shal- low, dry, nutrient-poor soil in the Great Alvar area (Stora Alvaret) of southern Oland, southeastern Sweden. Multivari- ate analysis of 0.001 m2 and 0.25 m2 quadrats within the plot showed that there is little floristic variation without any trend in the plot. Average species richness varied little throughout the study period from 1986 to 1991 with 1986 averages of 7.0 on 0.001m2, 16.3 on 0.01 m2, and 26.1 on 0.25 m2. On 0.001 m2 the highest species number found was 12, on 0.01 m2, 27. However, cumulative species richness, i.e. species number in the first year plus new species appearing in later years (aver- aged over 40 quadrats) increased over the same period, on 0.001 m2 from 7.0 in 1986 to 14.9 in 1991, and on 0.01 m2

459 citations

Journal ArticleDOI
TL;DR: A psychological contract perspective on the use of the open source development model as a global sourcing strategy-opensourcing, as it is called here-whereby commercial companies and open source communities collaborate on development of software of commercial interest to the company is presented.
Abstract: This paper presents a psychological contract perspective on the use of the open source development model as a global sourcing strategy-opensourcing, as we term it here-whereby commercial companies and open source communities collaborate on development of software of commercial interest to the company. Building on previous research on information systems outsourcing, a theoretical framework for exploring the opensourcing phenomenon is derived. The first phase of the research concerned qualitative case studies involving three commercial organizations (IONA Technologies, Philips Medical Systems, and Telefonica) that had "liberated" what had hitherto been proprietary software and sought to grow a global open source community around their product. We followed this with a large-scale survey involving additional exemplars of the phenomenon. The study identifies a number of symmetrical and complementary customer and community obligations that are associated with opensourcing success. We also identify a number of tension points on which customer and community perceptions tend to vary. Overall the key watchwords for opensourcing are openness, trust, tact, professionalism, transparency, and complementariness: The customer and community need to establish a trusted partnership of shared responsibility in building an overall opensourcing ecosystem. The study reveals an ongoing shift from OSS as a community of individual developers to OSS as a community of commercial organizations, primarily small to medium-sized enterprises. It also reveals that opensourcing provides ample opportunity for companies to headhunt top developers, hence moving from outsourcing to a largely unknown OSS workforce toward recruitment of developers from a global open source community whose talents have become known as a result of the opensourcing experience.

459 citations

Journal ArticleDOI
TL;DR: This paper investigated the linkage between drivers, mechanisms and barriers to knowledge creation and acquisition at the micro-level, and the development over time and across spatial settings of higher-order phenomena of localized institutions and other capabilities.
Abstract: This article aims to show how processes of knowledge development and their institutional underpinnings make up the core of evolutionary economic geography. We argue that micro level concepts—notably innovation, selection and retention—provide insights that can be helpful also when investigating evolutionary processes of knowledge creation at the aggregate levels of cities, regions or nations. We investigate the linkage between drivers, mechanisms and barriers to knowledge creation and acquisition at the micro-level, and the development over time and across spatial settings of higher-order phenomena of localized institutions and other capabilities. We apply this distinction on the analysis of the rise, growth, decline and possible rejuvenation of spatial clusters of similar and complementary economic activity.

458 citations

Journal ArticleDOI
TL;DR: Dose-dense induction followed by HDT/ASCT was well tolerated and led to long-term PFS in 44% of treatment-naive patients with PTCL, which represents an encouraging outcome, particularly considering the high median age and adverse risk profile of the study population.
Abstract: Purpose Systemic peripheral T-cell lymphomas (PTCLs) respond poorly to conventional therapy. To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy (HDT) ...

458 citations

Journal ArticleDOI
TL;DR: A group of protist experts proposes a two-step DNA barcoding approach, comprising a universal eukaryotic pre-barcode followed by group-specific barcodes, to unveil the hidden biodiversity of microbial Eukaryotes.
Abstract: Animals, plants, and fungi—the three traditional kingdoms of multicellular eukaryotic life—make up almost all of the visible biosphere, and they account for the majority of catalogued species on Earth [1]. The remaining eukaryotes have been assembled for convenience into the protists, a group composed of many diverse lineages, single-celled for the most part, that diverged after Archaea and Bacteria evolved but before plants, animals, or fungi appeared on Earth. Given their single-celled nature, discovering and describing new species has been difficult, and many protistan lineages contain a relatively small number of formally described species (Figure 1A), despite the critical importance of several groups as pathogens, environmental quality indicators, and markers of past environmental changes. It would seem natural to apply molecular techniques such as DNA barcoding to the taxonomy of protists to compensate for the lack of diagnostic morphological features, but this has been hampered by the extreme diversity within the group. The genetic divergence observed between and within major protistan groups greatly exceeds that found in each of the three multicellular kingdoms. No single set of molecular markers has been identified that will work in all lineages, but an international working group is now close to a solution. A universal DNA barcode for protists coupled with group-specific barcodes will enable an explosion of taxonomic research that will catalyze diverse applications.

458 citations


Authors

Showing all 36854 results

NameH-indexPapersCitations
Zhong Lin Wang2452529259003
Lewis C. Cantley196748169037
Darien Wood1602174136596
Kaj Blennow1601845116237
Christopher J. O'Donnell159869126278
Tomas Hökfelt158103395979
Peter G. Schultz15689389716
Frederik Barkhof1541449104982
Deepak L. Bhatt1491973114652
Svante Pääbo14740784489
Jan-Åke Gustafsson147105898804
Hans-Olov Adami14590883473
Hermann Kolanoski145127996152
Kjell Fuxe142147989846
Jan Conrad14182671445
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023240
2022643
20216,079
20205,811
20195,393
20185,067